BACKGROUND: Fatigue is one of the most common complaints of primary care practices and consists of symptoms of physical diseases and neurotic symptoms. This study was conducted to find that fatigue related to neurotic symptoms is as important as fatigue related to symptoms of the physical diseases itself. In addition to it, this study is to clarify and to understand the details of the neurotic symptoms. METHODS: In the course of six months(from April to september, 1996.), the 73 subjects were selected among the people that visited the outpatient department of family medicine with symptom of fatigue. The control group was selected from the healthy population which matched nearly the same number as the fatigue group. As tools of measurement, we used SCL-MPD consisted of 67 items. We performed statistical analysis among the data by means of SPSS/PC+. We analysed statistical dat,a for significance using non-parametric Mann-Whitney U test. RESULTS: There was no difference between the prevalence of men and women in the fatigue group. As the level of education decreased and employment increased, the proportion of patients that complained of fatigue increased. The fatigue group scored significantly higher than the control group in all questionnaire of SCL-MPD. The results of the somatization scale and phobic-anxiety were significant,ly high(p<0.01) and the rest of the scales were even more significantly high(p<0.001). Women scored higher in all aspects of SCL MPD than men. CONCLUSIONS: The author emphasize the importance of neurotic symptoms related to fatigue and biopsychosocial approach towards the patient. Considering the increase in medical cost and the decrease in productivity due to fatigue, there needs to be a thorough study on fatigue.
Education ; Efficiency ; Employment ; Fatigue* ; Female ; Humans ; Male ; Outpatients ; Prevalence ; Primary Health Care ; Weights and Measures ; Surveys and Questionnaires

No abstract available.
Humans ; Qualitative Research*

No abstract available.
Mass Screening*

The purpose of this article was to determine the discriminant function analysis of the Korean Wechsler Intelligence Scale (KWIS) for 110 normal controls and 98 schizophrenics. Of special interest was to verify the clinical discriminant power of two subtests of the KWIS (Vocabulary and Digit Symbols) and Zung's Self-rating Anxiety Scale (SAS). Four major hypotheses were postulated. The normal control group would show higher scores then the schizophrenics; mean scores on both Vocabulary and Digit Symbol. The mean difference in Digit Symbol between the two groups would be greater than that in the Vocabulary. There would be no significant relation among Digit Symbol, Vocabulary, and Anxiety. The most powerful discriminant power would be expected from subtest of Digit Symbol. The mean discriminant scores were 1.34425 for the control subjects, 1.34425 for the schizophrenics. The correctly discriminated percentage was 89.1% for the control subjects, 90.8% for the schizophrenics. From the findings it was concluded that both Digit Symbol and Vocabulary scales had strong diagnostic value but the former was more powerful than the latter. However, the Anxiety scales had less diagnostic value.
Anxiety ; Humans ; Intelligence ; Vocabulary ; Weights and Measures

No abstract available.
Complementary Therapies*

Cyclosporine A (CSA), a lipophilic cyclic undecapeptide, is not accumulated evently in all tissues and has a high affinity to several tissues such as lymphoid organs, liver, and kidneys. From this point of view, it is reasonable to assume that the amount of CSA uptake would be correlated with the extent of cell injury. On the other hand, verapamil, a Ca2+ channel blocker, bas been shown to ameliorate CSA nephrotoxicity. Since proximal tubule is the major site of drug transport and CSA uptake and its interaction with verapamil in isolated human renal proximal tubular cells. The CSA uptake rapidly increased over the first 5 min and then achieved almost steady-state after 10 min at all concentrations (0.5-10 uM). Kinetic analysis yielded that the Km and Vmax values of CSA were 5.6 uM and 86.2 p mol/mg cell protein/min, respectively. And Ca2+ depletion in media enhanced CSA uptake significantly but verapamil reduced it. These results suggest that the Ca2+ channels and CSA transporting sites on cell membrane are closely associated and that Ca2+ and CSA might be taken up competitively by proximal tubular cells.
Humans

Nephrotoxicity is the most common dose-limiting factor of cyclosporine A (CSA) in clinical usage. But the mechanism of CSA-induced nephrotoxicity still remains unresolved. Many authors insisted that CSA induced renal proximal tubular cell injury is due to the secondary effects following hemodynamic changes or endothelial cell damage, instead of direct toxicity by CSA. To find out that CSA has a direct toxicity to the proximal tubular cells, the author used primary cultures of human proximal tubular cells to eliminate the hemodynamic or endothelial influences that could be produced in in vivo model. In the present study, the viability against CSA was tested by the neutral red assay method with modulation of Ca2+ amount in incubating media and observed electron microscopically. The viability test showed direct toxic effect of CSA on human proximal tubular cells and this was enhanced by Ca2+ depletion in incubating media. Morphologically noted are accumulation of lipid droplets and polyribosomal dispersion, which may be association with inhibition of cellular synthetic activity. These results suggest the toxixity is a direct effect of cyclosporine and that toxic mechanism may be due to inhibition of cellular synthetic activity. And this experiment also showed that primary cultures of human renal proximal tubular cells can be a good in in vivo model for investigating CSA nephrotoxicity.
Humans

BACKGROUND: Chronically disabled rehabilitating patients influence their family members by their physical dysfunction. The purpose of this study was to know the relation of family function and physical function in disable person who is periodically treated in r ehabilitation department. METHODS: To know the family function according to physical disability, 64 patients(M/ F: 40/24) in rehabilitation clinic in 1 university hospital was studied by questionnaires including ADL(activity of daily living), IADL(instrumental actvity of daily living), FIM(functional independence measure), family APGAR. RESULTS: Causes of disabilities were stroke 2, traumatic brain injury 14, fracture 16, spinal cord injury 12, burn 2, arthritis 9, back pain syndrome 9 in order. Physical function of functional families was better than dysfunctional families. And physical function according to FIM score was statistically significant(p<0.05). Physical function was significantly(P value, ADL: 0.021, IADL: 0.009, FIM: 0.005) correlated with family APGAR score. CONCLUSIONS: Physical function and family function in rehabilitating patients with irreversible disability have significant correlations. Physician have to consider family function and dynamics in care of physically disabled patients.
Activities of Daily Living ; Apgar Score ; Arthritis ; Back Pain ; Brain Injuries ; Burns ; Disabled Persons ; Humans ; Rehabilitation ; Spinal Cord Injuries ; Stroke ; Surveys and Questionnaires

This study was to find out whether there were differences in the levels of depressions between positive and negative schizophrenics. This research was derived from the fact that negative schizophrenics show higher levels of depression than positive schizophrenics. This study also examined the levels of psychomotor dysfunction in positive and negative schizophrenics. For this study, there were 453 subjects. They consisted of 119 positive schizophrenics, 122 negative schizophrenics and 212 normal people. They were asked to complete Zung's Self-Rating Depression Scale(SDS) and to perform one subtest, Digit Symbol of KWIS(Korean Wechsler Intelligence SCALE). Subjects levels of depression were measured by the SDS. The level of psychomotor dysfunction was measured by Digit Symbol subtest of Korean Wechsler Intelligence Scale. ANOVA and Duncan's multiple comparison analysis were used to examine whether there were differences of depression and psychomotor dysfunction among the normal people, positive and negative schizophrenics. The results were as follows ; It was found that the depression level was higher in the negative schizophrenic patients than positive schizophrenic patients. Levels of depression were significantly higher in negative schizophrenics than positive schizophrenics. Psychomotor retardation symptom was the most effective variable that discriminates between the normals and the schizophrenics. And it would be concluded that the psychomotor dysfunction was more severe in negative schizophrenics than positive schizophrenics.
Depression* ; Humans ; Intelligence

No abstract available.
Motor Vehicles*