No abstract available.
Trichothiodystrophy Syndromes*

c-erbB-2 oncogene is a normal cellular proto-oncogene coding transmembrane glycoprotein structurally similar to the epidermal growth factor receptor. Amplification of this oncogene in a variety of human adenocarcinomas has been reported and is particularly well documented in breast carcinoma. It has been suggested that amplification of this oncogene is indicative of poor prognosis and is valuable only second to the lymph node status. Using immunohistochemical staining for the c-erbB-2 protein, overexpression of this protein was analysed in 228 primary breast cancer specimens and the frequency of overexpression and the relationship between overexpression and the other established prognostic variables are evaluated. Ninty three cases out of 228 cases(40.8%) show postive oncoprotein overexpression and using the chi-squared test for a trend, a significant correlation was found between c-erbB-2 protein staining and the histological grade, lymph node status, and estrogen receptor status(P<0.05). No significant association was found between staining and the patient's age and tumor size. Most of the tumors with histological types known to have good prognosis showed negative expression. Above findings strongly suggest that expression of c-erbB-2 oncogene is another independent indicator of poor prognosis in breast carcinoma.
Humans ; Adenocarcinoma ; Breast Neoplasms

Contusions ; Facial Bones ; Facial Nerve ; Facial Nerve Injuries ; Facial Paralysis ; Humans ; Incidence ; Lacerations ; Orbit ; Salivary Glands ; Skin ; Soft Tissue Injuries ; Wounds and Injuries

PURPOSE: To evaluate the incidence rate and risk factors for depression after amputation in treatment of the lower extremity open fracture associated with severe soft tissue injury. MATERIALS AND METHODS: We carried out a retrospective case-control study of 30 patients, who underwent lower extremity amputation between March 2002 and February 2012 and subsequently followed up over 12 months. We classified the patients into two groups: group A (study group, depression expressed) and group B(control group, normal). The risk factors were then subdivided based on patient-related factors such as whether or not patients received psychiatric treatment, sociolopsychological environmental factors, and daily activities after recovery. RESULTS: The overall incidence rate of depression was 40%;20 patients were male, and 10 patients were female (66.7% and 33.3%, respectively). Age (odd ratio=1.14), Accompanying injury (odd ratio=2.06), underlying disease, Psychiatric treatment (odd ratio=44.73), sociopsychological environment (odd ratio=17.53),daily activities (odd ratio=8.76) were significant. CONCLUSION: We concluded that the risk factors for depression after amputation are age, accompanying injury, and underlying diseases, irrespective of whether or not patients received psychiatric treatment, and not associated with isolated sociopsychological environments, or hypoactivity of daily living.
Amputation* ; Case-Control Studies ; Depression* ; Female ; Fractures, Open* ; Humans ; Incidence ; Lower Extremity* ; Male ; Retrospective Studies ; Risk Factors* ; Soft Tissue Injuries*

OBJECTIVES: Suicide has become one of the most serious public health problems today in Korea. In this study, we investigated the demographic and social characteristics affecting the use of various suicide methods.METHODS: The data relating to the types of suicide deaths including factors such as the age, gender, education level, the time of death, the place of death, and the method of death reported from 2008 to 2014 in Yeoungdeungpo-gu, Seoul, which were reviewed and analyzed in this study. The variants of each suicide method were compared using a Chi square and the Fisher's exact test. Additionally, a Spearman correlation analysis and a logistic regression analysis were also performed.RESULTS: The results noted that more than half of suicide victims (68.4%) were male. The most frequent suicide deaths were in the spring (29.1%), and were performed during the afternoon (33.4%). In this review, it is noted that the methods of hanging (59.4%), leaping (17.0%), and gas intoxication (8.9%) were the most frequent suicide methods used by the suicide victims. A logistic regression analysis showed that poisoning had a lower risk of occurrence in night/morning time. In fact, gas poisoning was more dangerous in males, especially males who were younger, and occurred more frequently in the winter months. In this respect, the method of hanging was found to be higher in the low-educated group of people who committed suicide as reviewed. It is noted that drowning was a riskier factor in females, who were elderly and who committed suicide more frequently in the summer. The risk of leaping was increased in elderly populations who were also noted to be highly-educated.CONCLUSION: There was a significant difference in sex, age, educational level, season, suicide time, and suicide location according to each suicide method as reviewed and utilized in this study. The results note that it is necessary to emphasize the prevention of different suicide methods according to population groups.
Aged ; Drowning ; Education ; Female ; Gas Poisoning ; Humans ; Korea ; Logistic Models ; Male ; Methods ; Mortality ; Poisoning ; Population Groups ; Public Health ; Seasons ; Seoul ; Sociological Factors ; Suicide

BACKGROUND: The purpose of this study was to assess the lifestyle associated with weight gain and persistent overweight for 2 years. METHODS: The subjects were 580 workers (109 men, 471 women) at one university affiliated hospital. Their height and weight were measured twice in 2000 and 2002. A questionnaire, about lifestyle was filled out in 2000. The questionnaire included the average amount of alcohol intake and the number of days per week in which alcohol was consumed, smoking status, and the number of days per week in which exercise was done. Their weight change in 2 years was calculated and their weight status was classified into two groups: persistent normal weight (BMI <23 kg/m2) and persistent overweight (BMI> or =23 kg/m2). RESULTS: Among the total, 54.3% of men and 10.0% of women had persistent overweight over 2 years. Overall 93.4% of overweight men and 68.7% of overweight women remained overweight after 2 years. Compared with male non-smokers and male ex- smokers, current male smokers gained weight as much as 1.17 kg over 2 years after adjusting for age and initial BMI (P=0.033). Compared with females who exercised less than 3 per week, those who exercised 3 or more per week lost weight as much as 1.21 kg over 2 years after adjusting for age and initial BMI (P=0.005). Compared with males who consumed alcohol an average of< or =30 g per consumption, those who consumed an average of > 30 g were 4.1 times (95% C.I. 1.04~16.21) more likely to maintain persistent overweight over 2 years after adjustment for age and frequency of alcohol use. However no particular lifestyle was shown to predict the risk of persistent overweight for women. CONCLUSION: Regular exercise of moderate intensity and modest alcohol consumption seemed to prevent weight gain and persistent overweight. Such lifestyle may be encouraged to maintain healthy weight.
Alcohol Drinking ; Female ; Follow-Up Studies ; Humans ; Life Style* ; Male ; Overweight* ; Smoke ; Smoking ; Weight Gain*

No abstract available.
Coronary Artery Disease* ; Coronary Vessels* ; Electrocardiography* ; ROC Curve*

Primary colonic lymphoma is a rare disease and open surgical biopsy is usually necessary for hietological confirmation. Despite the submucosal location of the tumors, histological confirmation is frequently made by endoscopic multiple punch biopsies. Recently, three patients were admitted to the hospital with right lower guadrant abdominal pain, mass and abnormalities in the right colon and cecum on the barium enema. We performed colonoscopy and found smooth surfaced polypoid mass with occasional shallow ulcerations without lobulation, so suspected lymphoma endoscopically but failed to confirm histologieal diagnosis by usual punch biopsy. Thereafter, all three cases were undergone to laparntomies, and two were confirmed to be non-Hodgkins lymphoma and the other was Hodgkins disease. Here, we present those three cases of endoscopically found colonic lymphoma with review of literatures.
Abdominal Pain ; Barium ; Biopsy ; Cecum ; Colon* ; Colonoscopy ; Diagnosis ; Enema ; Hodgkin Disease ; Humans ; Lymphoma* ; Lymphoma, Non-Hodgkin ; Rare Diseases ; Ulcer

Left ventricular(LV) diastolic filling is abnormal at rest in many patients with coronary arery disease, even in the presence of normal resting LV systolic function. To determine the effects of improved myocardial perfusion on impaired LV diastolic filling and to detect the most sensitive parameter to assess LV diastolic function, gated radionuclide ventriculography were performed in 14 patients with coronary artery disease before and after successful percutaneous transluminal coronary angioplasty(PTCA). All patients had no previous myocardial infarction and no abnormal wall motion in gated radionuclide and contrast ventriculography. The following results were obtained; 1) There were no significant differences in the parameters of LV systolic function, such as peak ejection rate(PER, time to peak ejection rate(TPER), ejection fraction(EF) after successful PTCA. 2) Peak filling rate(PFR) and time to peak filling rate(TPFR), indexes of LV diastolic function, had no significant changes after successful PTCA. 3) The percent contribution of late diastolic filling to stroke volume(%LDF/SV) decreased from 26.5+/-6.8% to 19.1+/-6.6%(p<0.005 by paired t-test). These data suggest that in many patients with angina and normal LV systolic function, impaired global diastolic filling is a reversible manifestation of impaired coronary flow, and percent contribution of late diastolic filling to stroke volume(%LDF/SV) can be a sensitive parameter to evaluate impaired LV diastolic filling in coronary artery disease.
Angina Pectoris* ; Angioplasty, Balloon, Coronary* ; Coronary Artery Disease ; Gated Blood-Pool Imaging ; Humans ; Myocardial Infarction ; Perfusion ; Radionuclide Ventriculography ; Stroke

To evaluate left ventricular diastolic function in patients with coronary artery disease, gate radionuclide ventriculography was performed prospectively in 42 patients who were admitted to Seoul National University Hospital from November 1985 to August 1986 because of anterior chest pain. All patients had no valvular heart disease, congenital heart disease, cardiomyopathy and arrhythmia, and no abnormal vall motion in gated nuclide ventriculography and contrast left ventriculography. 25 patients with more than 50% of stenosis in coronary arteriography were compared with 17 control subjects without stenosis. The following results were obtained; 1) There were no significant differences between normal controls and patients with coronary artery disease in the analysis of the parameters of the left ventricular systolic function, such as ejection fraction (EF), peak ejection rate (PER), time to peak ejection rate (TPER) and ejection time (TES, TES/BCL). 2) Same results were found with those of the left vnetricular diastolic function, such as peak filling rate (PFR), diastolic time interval (DTI, DTI/BCL), rapid diastolic filling interval and time to late diastolic filling (TLDF). 3) The percent contribution of late diastolic filling to stroke volume (%LDF/SV) was more increased in patients with coronary artery disease than the normal control subjects (38.2+/-12.4% vs 28.3+/-7.8%, P<0.01). 4) As the results of above, it can be concluded that the percent contribution of late diastolic filling to stroke volume (%LDF/SV) obtained by using the non-invasive method of gated radionuclide ventriculography can be a sensitive parameter for early evaluation of the left ventricular diastolic dysfunction in coronary artery disease.
Angiography ; Arrhythmias, Cardiac ; Cardiomyopathies ; Chest Pain ; Constriction, Pathologic ; Coronary Artery Disease* ; Coronary Vessels* ; Gated Blood-Pool Imaging ; Heart Defects, Congenital ; Heart Valve Diseases ; Humans ; Prospective Studies ; Radionuclide Ventriculography ; Seoul ; Stroke Volume