1.Expression of Surfactant-D Protein and TNF-alpha in the Interaction of Pneumocystis Carinii and Alveolar Macrophages in Pneumocystis Carinii Pneumonia.
Kun Young KWON ; Kwan Kyu PARK ; Chang Kwon PARK ; Young June JEON ; Eun Sook CHANG
Korean Journal of Pathology 1999;33(9):684-694
Alveolar macrophages participate in the host defense against P. carinii, but the mechanisms in degradation and clearance of the organism from lung has not been well established. We observed the transmission and scanning electron microscopic features and evaluated the expression of TNF-alpha and Surfactant-D in the interaction of P. carinii with alveolar macrophages. Expression of TNF-alpha and Surfactant-D in the experimentally induced P. carinii pneumonia in rat was examined by immunohistochemistry and immunoelectron microscopy. Electron microscopically, the alveolar macrophages phagocytized trophozoites and cysts of P. carinii micro-organisms. Immunohistochemically TNF-alpha was strongly expressed in the cytoplasms of alveolar macrophages. Postembedding immunogold labeling for Surfactant-D protein was expressed on the pellicles of trophozoites and cysts, P. carinii micro-organisms in the cytoplasms of macrophages, free floating surfactant materials and multilamellar bodies of type II epithelial cells. We conclude that alveolar macrophages interacted with P. carinii micro-organisms respond with increased expression of TNF-alpha. TNF-alpha may bind to P. carinii and exert a direct toxic effect upon the micro-organisms. Surfactant-D protein may augment binding of P. carinii to the alveolar macrophages and enhance the clearance of the micro-organisms.
Animals
;
Cytoplasm
;
Epithelial Cells
;
Immunohistochemistry
;
Lung
;
Macrophages
;
Macrophages, Alveolar*
;
Microscopy, Immunoelectron
;
Pneumocystis carinii*
;
Pneumocystis*
;
Pneumonia
;
Pneumonia, Pneumocystis*
;
Rats
;
Trophozoites
;
Tumor Necrosis Factor-alpha*
2.Adrenal function in active pulmonary tuberculosis.
Jae Suk HWANG ; Keun Yong PARK ; Seung Beom HAN ; In Kyu LEE ; Young June JEON
Journal of Korean Society of Endocrinology 1992;7(1):61-65
No abstract available.
Tuberculosis, Pulmonary*
3.Effects of Histamine and Hydroxyzine on the Bladder Contraction of Rat.
Sung Kyu HONG ; Eun Chan PARK ; Seung June OH ; Hwang CHOI
Korean Journal of Urology 2000;41(3):435-443
No abstract available.
Animals
;
Histamine*
;
Hydroxyzine*
;
Rats*
;
Urinary Bladder*
4.A Case Report of Familial Osteopoikilosis
Seung Ho YUNE ; June Kyu LEE ; Sang Rho AHN ; Sang Yeon RHA ; Chan Hee PARK
The Journal of the Korean Orthopaedic Association 1986;21(6):1133-1136
Osteopoikilosis is an asymptomatic osteosclerotic dysplasia, initially described by Albers-Schönberg and Ledoux-Lebard and associates. This disorder is described as extremely rare. Inherited and sporadic cases of osteopopikilosis have been reported. A Case of familial osteopoikilosis is presented with a brief review of literatures.
Osteopoikilosis
5.Transoral Removal of Submandibular Stone.
Korean Journal of Otolaryngology - Head and Neck Surgery 2006;49(1):60-65
BACKGROUND AND OBJECTIVES: Traditionally, the treatment of choice for submandibular calculi that lie in the proximal duct or gland parenchyme has been sialadenectomy despite its risk. Recently, minimally invasive techniques including lithotripsy, sialendoscope have been reported, although these techniques have some limitations on large, infected calculi. The aim of this present review is to assess the transoral removal of submandibular calculi. SUBJECTS AND METHOD: The records of a hundred and sixty-three patients who underwent transoral removal of submandibular calculi between January 1, 1995 and July 31, 2004 were retrospectively reviewed. RESULTS: The complete removal of calculi was observed in 147 (90.2%) patients, partial removal with residual calculi in 8 (4.9%) patients and failure of removal in 8 (4.9%) patients. The removal rate of palpable calculi was significantly high. The removal rate of anterior, infection-free calculi was higher than the posterior and infected calculi, but there was no statistical significance. The size of calculi was not related with the removal rate of calculi. A hundred fifty-two (93.3%) of 155 patients in whom some or all of calculi were removed were free of symptoms of calculi. Symptoms were recurred in 19 patients after 2-68 (median 24) months and in 13 patients calculi were removed transorally again. CONCLUSION: The transoral removal of calculi is useful in preservation of the submandibular gland and effective in palpable calculi regardless of location, size, and combined infection.
Calculi
;
Humans
;
Lithotripsy
;
Oral Surgical Procedures
;
Retrospective Studies
;
Salivary Calculi
;
Submandibular Gland
6.Trend of Antibiotic Use in Children with Acute Otitis Media in Korea
Kyu Hyun PARK ; Seung-Ah CHOE ; Ju-Young SHIN ; Young June CHOE
Journal of Korean Medical Science 2021;36(46):e317-
Public interventions have shown to optimize the use of antibiotics in children with acute otitis media (AOM). In this study, we describe the AOM-related antibiotic use among children in South Korea using national cohort data. We retrieved the Health Insurance Review & Assessment Service data to construct a national cohort of children aged 0–6 years who had been diagnosed with AOM between 2012 and 2018. Of 25,212,264 children included, the antibiotic prescription has increased for amoxicillin/amoxicillin-clavulanate from 56.1% in 2012 to 61.8% in 2018. Prescription has decreased for cephalosporin (35.1% in 2012 to 31.8% in 2018) and macrolide (8.7% in 2012 to 6.4% in 2018). National cohort data have shown an increased trend in AOM-related aminopenicillin prescription and downward trend cephalosporin and macrolide use in South Korea. A multi-faceted approach is required to control the antimicrobial resistance at a population level.
7.A Case of Localized Skin Infection Due to Scedosporium Apiospermum.
Myung IM ; Hyun Woong KIM ; Young June SEO ; Jeung Hoon LEE ; Jang Kyu PARK ; Moo Kyu SUH
Korean Journal of Dermatology 2004;42(11):1505-1507
Scedosporium(S). apiospermum is the asexual stage of Pseudallescheria boydii. This ubiquitous fungus causes not only mycetoma but also infection of a variety of body sites including the skin. Localized skin infection without grain production due to this organism is much rarer than mycetoma. We report a case of cutaneous S. apiospermum infection which occured in a 75-year old female. She had multiple suppurative nodules with pustules on a dark red plaque at the dorsum of the right forearm. Cultural isolation for definitive diagnosis showed typical S. apiospermum. The patient was treated successfully with oral terbinafine 250mg daily for 1 week and oral itraconazole 200mg daily for 3 weeks.
Aged
;
Edible Grain
;
Diagnosis
;
Female
;
Forearm
;
Fungi
;
Humans
;
Itraconazole
;
Mycetoma
;
Pseudallescheria
;
Scedosporium*
;
Skin*
8.A Case of Idiopathic Hypertrophic Cranial Pachymeningitis Associated with Tolosa-Hunt Syndrome.
Eun Joo KIM ; Kyung Pil PARK ; Dae Seong KIM ; Dae Soo JUNG ; Kyu Hyun PARK ; Dong June PARK ; Boo Sup OUM
Journal of the Korean Neurological Association 2001;19(1):56-59
Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare disease, which causes chronic progressive inflammation and thickening of the basal dura mater and produces multiple cranial neuropathies, headache, ataxia, and seizure. A 40 year-old man presented with a continuous, diffuse, dull headache with left periorbital pain, exophthalmos, ptosis and loss of visual perception. Brain MRI revealed thickened, highly enhanced pachymeninges in all supratentorial areas in association with the left cavernous sinus. A subsequent meningeal biopsy showed non-specific chronic inflammations of the pachymeninges. The patient dramatically responded to steroid therapy. To our knowledge, this is an extremely rare case of IHCP associated with Tolosa-Hunt syndrome. (J Korean Neurol Assoc 19(1):56~59, 2001
Adult
;
Ataxia
;
Biopsy
;
Brain
;
Cavernous Sinus
;
Cranial Nerve Diseases
;
Dura Mater
;
Exophthalmos
;
Headache
;
Humans
;
Inflammation
;
Magnetic Resonance Imaging
;
Meningitis*
;
Rare Diseases
;
Seizures
;
Tolosa-Hunt Syndrome*
;
Visual Perception
9.The Change of the Frontal Hair Line According to the Treatment for Androgenetic Alopecia.
Bo Joong KIM ; Young Ok PARK ; Young June SEO ; Jeung Hoon LEE ; Jang Kyu PARK
Korean Journal of Dermatology 2006;44(9):1065-1071
BACKGROUND: Androgenetic alopecia (AGA) occurs as a result of progressive miniaturization of scalp hair in genetically predisposed individuals. Several effective treatments for AGA are well known. However, there is a paucity of literature about the influence of such treatments on the frontal hair line (FHL). OBJECTIVE: To assess the effectiveness of oral finasteride and/or topical minoxidil on the FHL. METHODS: An assessment of 100 male patients with AGA of grades II to IV was made, based on the Norwood- Hamilton scale after six months of treatment. The patients were divided into three groups. Group 1 received 1 mg of oral finasteride daily. Group 2 exclusively used 5% minoxidil solution 1 ml twice daily. Group 3 received 1 mg of finasteride daily in combination with a topical application of 5% minoxidil solution. We measured the length from the mid-pupillary line to three points of the FHL with calipers; midpoint of the forehead, and right and left temporal recession, respectively. RESULTS: An improvement of the FHL was observed in all of three groups. There was a tendency for patients taking only finasteride to show an overall improvement in the frontal hair line, while patients applying only minoxidil solution showed an improvement in both temporal recession lines. Comparing the three groups at three points of the FHL respectively, at both temporal recession of the FHL, Group 3 showed the best result, followed by Group 2, and finally Group 1. The center of the FHL Group 3 showed the best result, followed by Group 1, and finally Group 2. CONCLUSION: We found that the combination therapy of finasteride and minoxidil had a synergic effect on FHL in the treatment of androgenetic alopecia. In the assessment of treatment efficacy to the FHL of patients with AGA, the method of using calipers in this study was worthwhile.
Alopecia*
;
Finasteride
;
Forehead
;
Hair*
;
Humans
;
Male
;
Miniaturization
;
Minoxidil
;
Scalp
;
Treatment Outcome
10.Posterior and Anterolateral Approaches in a Single Stage to Dumbbell Tumors of the Spine.
Kyu Hyup CHO ; Yeun Mook PARK ; Seung Lae KIM ; June Sik PARK ; Bong Hyun CHANG
Journal of Korean Neurosurgical Society 1996;25(4):802-811
The surgical approach to spinal tumors varies not only with the level and location of the tumor, but also with the type and extent of the tumor. Some of the dumbbell neurofibroma(neurilemmoma) can be removed through simple laminectomy, but usually are approached through two separate incisions by two stages. In this report, posterior and anterolateral approaches in a single stage to dumbbell neurofibroma(neurilemmoma) of the spinal region are described. This approach provides full exposure of intra- and paraspinal portions of the tumor, thus permitting safe dissection and total removal. Six patients who underwent this procedure are described to illustrate its application.
Humans
;
Laminectomy
;
Neurofibroma
;
Spine*