1.Management of Recurrent Thyroid Carcinoma with Negative Diagnostic Radioiodine Whole - Body Scan.
Korean Journal of Nuclear Medicine 2001;35(3):117-124
No abstract available.
Thyroid Gland*
;
Thyroid Neoplasms*
2.Clinical Application Positron Emissio Tomogray in Oncloy.
Journal of the Korean Medical Association 2001;44(11):1213-1224
Positron Emission Tomography(PET) is a new imaging modality to make biochemical metabolic images. Because biochemical changes precede anatomical changes in most of diseases including cancer, PET can detect earlier changes of diseases than conventional anatomical imaging modalities. PET can also characterize biochemical property of diseases. A PET center is composed of a medical cyclotron, synthesis system of radiopharmaceuticals and scanner. For PET oncology, several positron-emitting radiopharmaceuticals have been developed. Among them, F-18-fluorodeoxyglucose (FDG) is most frequently used. Higher rate of glucose metabolism has been observed in cancer cells. Like glucose, FDG is transported into the cancer cells and converted to FDG-6-phosphate by hexokinase. FDG-6-phosphate is trapped in the cytoplasm, and emits gamma rays to make PET images. The current application of FDG PET in oncology is in detection, differentiation, and staging of the primary tumors, grading malignancy, monitoring therapeutic response, and early detection of recurrence. Nowadays, PET is an established procedure for staging the diseases and detecting the recurrence in many cancers, especially the lung, colorectal, and head and neck cancers, melanoma, and lymphoma. PET is a regular part of medical insurance reimbursement in many developed countries, and becomes a valuable research tool in oncology as well as an important imaging modality in managing cancer patients.
Cyclotrons
;
Cytoplasm
;
Developed Countries
;
Electrons*
;
Gamma Rays
;
Glucose
;
Head
;
Hexokinase
;
Humans
;
Insurance
;
Lung
;
Lymphoma
;
Melanoma
;
Metabolism
;
Neck
;
Radiopharmaceuticals
;
Recurrence
3.Application of PET in Brain Tumor.
Korean Journal of Nuclear Medicine 2002;36(1):19-27
No abstract available.
Brain Neoplasms*
;
Brain*
4.Application of PET in Brain Tumor.
Korean Journal of Nuclear Medicine 2002;36(1):19-27
No abstract available.
Brain Neoplasms*
;
Brain*
5.Mechanisms of Glucose Uptake in Cancer Tissue.
Korean Journal of Nuclear Medicine 1999;33(1):1-10
Cancer cells are known to show increased rates of glycolysis metabolism. Based on this, PET studies using F-18-fluorodeoxyglucose have been used for the detection of primary and metastatic tumors. To account for this increased glucose uptake, a variety of mechanisms has been proposed. Glucose influx across the cell membrane is mediated by a family of structurally related proteins known as glucose transporters (Gluts). Among 6 isoforms of Gluts, Glut-1 and/or Glut-3 have been reported to show increased expression in various tumors. Increased level of Glut mRNA transcription is supposed to be the basic mechanism of Glut overexpression at the protein level. Some oncogens such as src or ras intensely stimulate Glut-1 by means of increased Glut-1 mRNA levels. Hexokinase activity is another important factor in glucose uptake in cancer cells. Especially hexokinase type II is considered to be involved in glycolysis of cancer cells. Much of the hexokinase of tumor cells is bound to outer membrane of mitochondria by the porin, a hexokinase receptor. Through this interaction, hexokinase may gain preferred access to ATP synthesized via oxidative phosphorylation in the inner mitochondria compartment. Other biologic factors such as tumor blood flow, blood volume, hypoxia, and infiltrating cells in tumor tissue are involved. Relative hypoxia may activate the anaerobic glycolytic pathway. Surrounding macrophages and newly formed granulation tisssue in tumor showed greater glucose uptake than did viable cancer cells. To expand the application of FDG PET in oncology, it is important for nuclear medicine physicians to understand the related mechanisms of glucose uptake in cancer tissue.
Adenosine Triphosphate
;
Anoxia
;
Biological Factors
;
Blood Volume
;
Carcinogens
;
Cell Membrane
;
Glucose*
;
Glycolysis
;
Hexokinase
;
Humans
;
Macrophages
;
Membranes
;
Metabolism
;
Mitochondria
;
Nuclear Medicine
;
Oxidative Phosphorylation
;
Protein Isoforms
;
RNA, Messenger
6.Applicationof Positron Emission Tomography in Gastrointestimal Carcinomas.
The Korean Journal of Hepatology 1996;2(2):129-133
No abstract available.
Electrons*
;
Positron-Emission Tomography*
7.The Usefulness of Myocardial SPECT for the Preoperative Cardiac Risk Evaluation in Noncardiac Surgery.
Myung Chul LEE ; Dong Soo LEE ; Won Jun KANG ; June Key CHUNG ; Seok Tae LIM
Korean Journal of Nuclear Medicine 1999;33(3):273-281
PURPOSE: We investigated whether myocardial SPECT had additional usefulness to clinical, functional or surgical indices for the preoperative evaluation of cardiac risks in noncardiac surgery. MATERIALS AND METHODS: 118 patients (M: F=66:52, 62.7+/-10.5 years) were studied retrospectively. Eighteen underwent vascular surgeries and 100 nonvascular surgeries. Rest T1-201/stress Tc-99m-MIBI SPECT was performed before operation and cardiac events (hard event: cardiac death and myocardial infarction; soft event: ischemic ECG change, congestive heart failure and unstable angina) were surveyed through perioperative periods (14.6+/-5.6 days). Clinical risk indices, functional capacity, surgery procedures and SPECT findings were tested for their predictive values of perioperative cardiac events. RESULTS: Peri-operative cardiac events occurred in 25 patients (3 hard events and 22 soft events). Clinical risk indices, surgical procedure risks and SPECT findings but functional capacity were predictive of cardiac events. Reversible perfusion decrease was a better predictor than persistent decrease. Multivariate analysis sorted` out surgical procedure risk (p=0.0018) and SPECT findings (p=0.0001) as significant risk factors. SPECT could re-stratify perioperative cardiac risks in patients ranked with surgical procedures. CONCLUSION:: We conclude that myocardial SPECT provides additional predictive value to surgical type risks as well as clinical indexes or functional capacity for the prediction of preoperative cardiac events in noncardiac surgery.
Death
;
Electrocardiography
;
Heart Failure
;
Humans
;
Multivariate Analysis
;
Myocardial Infarction
;
Myocardial Ischemia
;
Perfusion
;
Perioperative Period
;
Retrospective Studies
;
Risk Factors
;
Tomography, Emission-Computed, Single-Photon*
8.Quantative measurement of tumor-associated antigen by autoradiography.
June Key CHUNG ; Dong Soo LEE ; Myung Chul LEE ; Chang Soon KOH ; James C REYNOLDS
Journal of the Korean Cancer Association 1991;23(4):740-748
No abstract available.
Autoradiography*
9.PET Application in Thyroid Cancer.
Journal of Korean Society of Endocrinology 2004;19(1):1-9
No abstract available.
Thyroid Gland*
;
Thyroid Neoplasms*