1. Analysis of 8 274 cases of new coronavirus nucleic acid detection and co-infection in Wuhan
Ming WANG ; Qing WU ; Wanzhou XU ; Bin QIAO ; Jingwei WANG ; Hongyun ZHENG ; Shupeng JIANG ; Junchi MEI ; Zegang WU ; Yayun DENG ; Fangyuan ZHOU ; Wei WU ; Yan ZHANG ; Zhihua LYU ; Jingtao HUANG ; Xiaoqian GUO ; Zhen CHEN ; Lina FENG ; Zunen XIA ; Di LI ; Tiangang LIU ; Pingan ZHANG ; Yongqing TONG ; Zhiliang XU ; Yan LI
Chinese Journal of Laboratory Medicine 2020;43(0):E016-E016
Objective:
To investigate the positive rate for 2019-nCoV tests and co-infections in Wuhan district.
Methods:
A total of 8 274 cases in Wuhan were enrolled in this cross-sectional study during January 20 to February 9, 2020, and were tested for 2019-nCoV using fluorescence quantitative PCR. Both respiratory tract samples (nasopharynx, oropharynx, sputum and alveolar lavage fluid) and non-respiratory tract samples (urine, feces, anal swabs, blood and conjunctival sac swabs) were collected. If both orf1ab and N genes are positive, they are classified as nucleic acid test positive group; if both orf1ab and N genes are negative, they are classified as negative group; if single gene target is positive, they are classified as suspicious group. Individuals were divided into male group and female group according to sex. At the same time, 316 patients were tested for 13 respiratory pathogens by multiplex PCR.
Results:
Among the 8 274 subjects, 2 745 (33.2%) were 2019-nCoV infected; 5 277 (63.8%) subjects showed negative results in the 2019-nCoV nucleic acid test; and 252 cases (3.05%) was not definitive (inconclusive result). The age of cases with COVID-19 patients and inconclusive cases was significantly higher than that of cases without 2019-nCoV infection (40 vs 56,
Result Analysis
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