2.Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances.
Zhijing LIU ; Cong XU ; Ran TIAN ; Wan WANG ; Jiage MA ; Liya GU ; Fei LIU ; Zhanmei JIANG ; Juncai HOU
Journal of Zhejiang University. Science. B 2021;22(7):533-547
Lactic acid bacteria (LAB) are a representative probiotic. As the dominant flora in the human intestinal tract, LAB can regulate the balance of human intestinal flora and improve host health. The purpose of this study was to isolate and screen LAB that are well suited to the intestinal characteristics of the Chinese population, with excellent probiotics and high antibacterial activity. After 16S ribosomal RNA (rRNA) homology and phylogenetic tree analysis, potential probiotics were tested for their antibacterial activity, resistance to artificial gastrointestinal fluid and drugs, surface hydrophobicity, and safety. Three strains of LAB with acid resistance, bile salt resistance, epithelial cell adhesion, and no multidrug resistance were selected:
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