Objective To compare the clinical feature and cognitive function between patients with obsessive-compulsive disorder of different onset age and explore possible subtype.Methods 140 Patients with obsessive-compulsive disorder (OCD) were enrolled in test.All finished a series of tests including clinical feature,Trail-making test (TMT),Tower of Hanoi (TH) and Word fluency test (WFT).Patients were divided into two groups by onset age of 18.Results Compared with patients of onset age after18,patients of onset before18 were more with episode duration and more suicide attitude( x2 =4.214,x2 =11.542,P＜ 0.05 ).In TMT patients of onset before 18 had shorter time and little errors( (81.696 ±50.172)vs( 109.114 ±48.070),(1.169 ±2.983) vs ( 1.405 ± 2.020),P ＜ 0.05 ).Conclusion Obsessive-compulsive disorder with different onset age may be different type.

0.05).The most common adverse reactions of imiquimod were erythema,erosion,itching,excoriation,scabbing and oedema,those of podophyllotoxin were burning sensation,inflammation,erosion,pain,itching and bleeding.The incidence of ADR of podophyllotoxin was higher.Cost-effectiveness analysis indicated that the C/E of imiquimod and podophyllotoxin was36.88and8.15respectively.CONCLUSION:Imiquimod and podophyllotoxin possessed similar curative effect on condylo?ma acuminatum,but the cost and C/E of podophyllotoxin were lower.At the same time,podophyllotoxin had more serious ad?verse reactions.

OBJECTIVE:To evaluate the cost-effectiveness of levofloxacin and sparfloxacin in the treatment of non?gonococcus urethritis(cervicitis)patients.METHODS:The clinical data of levofloxacin and sparfloxacin in the treatment of nongonococcus urethritis were collected with evidence-based medicine method and were evaluated with pharmacoeconomic cost-effectiveness analysis.RESULTS:The cure rates of two drugs were71.16%(62.00%,80.32%),81.69%(78.71%,85.21%)and cost-effectiveness ratios were2.29and2.71respectively.The?C/?E was5.57.CONCLUSION:The cost-ef?fectiveness ratio of levofloxacin was lower than that of sparfloxacin although the cure rate of sparfloxacin for nongonococcus urethritis was better.

Animals ; Cattle ; Humans ; Infant ; Infant Formula ; Milk Hypersensitivity ; Milk Proteins ; adverse effects

OBJECTIVE: To explore the effect of treating periarthritis of shoulder with manipulation through evaluating clinical reports with the theory of evidence-based medicine (EMB). METHODS: By retrieval of some main medical literature databases in the past 5 years, 242 articles on treating periarthritis of shoulder with manipulation were available. Selected by admission standard, 10 of them were evaluated with EBM theory. RESULTS: Both single-application and union-application of manipulation were effective to periarthritis of shoulder, but the evaluated articles were all low-quality articles. CONCLUSION: Because of low quality clinic test and larvaceous publication bias, the extant evidence is not enough to recommend replacing other therapeutic methods by manipulation. The low quality of evaluated articles suggests that there exist some methodology problems in the clinic test on treating periarthritis of shoulder with manipulation.

Increasing aged care requisite has become a serious challenge all over the world. Compared with developed countries, aged care in China still has some limitations, i.e., lack of qualified professionals, aged care system needs to be improved, and lack of aged long term care insurance. This article discussed these points and put forward the corresponding countermeasures.

The intestine microbiota and the host interacts with each other.Resently,the association and causality between gut microbiota and cardiovascular diseases have been well studied.Some underlying mechanisms,especially metabolic pathways are known, including the role of trimethylamine N-oxide in the pathogenesis of atherosclerotic heart disease and heart failure and that of short chain fatty acids and their receptors in blood pressure regulation.

Objective To review the recent studies about sentinel lymph node biopsy in breast cancer. Methods The literatures in recent years on the history, concept, technique and clinical application of sentinel lymph node biopsy were reviewed and summarized.Results There was no unified method for sentinel lymph node biopsy. There was a wide range of detection rate and false negative rate.Conclusion Prospective multi center random clinical trials will help to evaluate the clinical application of sentinel lymph node biopsy.

With the mature of techniques and development of equipments in excimer laser corneal refractive surgery,the postoperative complications are decreasing gradually.As the center of cornea become thin after laser in situ keratomileusis (LASIK)and laser subepithelial keratomileusis ( LASEK ),the strength of cornea and the intraocular pressure relatively step down,which can cause cornea anterior protrusion more or less.Because the posterior surface which is not directly affected by surgical process and healing process,so it is usually used to evaluate the protrusion of cornea.As the application of.ophthalmic anterior segment imaging and analysis system,we can get more message of cornea posterior surface.The manifestation,principle and precautionary measures of corneal posterior surface anterior protrusion after the excimer laser corneal refractive surgery were reviewed.