Necrosis is also tightly controlled by signaling path-ways,thus it is called as regulated necrosis,which includes ne-croptosis,ferroptosis,parthanatos and CypD-mediated necrosis. It has been shown that regulated necrosis is closely related to the occurrence,development and prognosis of injury-relevant disea-ses such as myocardial infarction,stroke,neurodegenerative dis-eases.It will be significant for prevention and therapy of injury-relevant diseases to clarify the signal transductions and regulatory mechanisms for the regulated necrosis.

Objective To investigate the clinical efficacy and safety of alteplase thrombolysis in the treatment of patients with acute ischemic stroke.Methods 42 patients with acute ischemic stroke were randomly divided into the control group and the study group.1 8 cases in the control group were treated by urokinase thrombolysis, and 24 cases in the study group were treated by alteplase thrombolysis.The clinical efficacy and safety were compared between the two groups.Results The total effective rate of the study group(91 .7%)was higher than that of the con-trol group(77.8%),and the difference was statistically significant(χ2 =9.7,P <0.01 ).Compared with the control group,the total vascular patency rate was higher,the difference was statistically significant(χ2 =97.6,P <0.01 ).The NIHSS score was lower in the two groups after treatment(t =1 0.1 58,1 5.962,all P <0.05),and that in the study group was more lower,the difference between the two groups was statistically significant(t =1 0.564,P <0.05 ). Conclusion Alteplase thrombolysis in the treatment of acute ischemic stroke patients,thrombolytic therapy for patients,in the use of drugs within the time window patients can get good clinical curative effect,no more than drug use the most extensive restrictions rarely cause patients with intracranial hemorrhage,and being suitable for populari-zation and application.

Actinomycosis ; pathology ; Adult ; Diagnosis, Differential ; Female ; Humans ; Mycoses ; pathology ; Staphylococcal Skin Infections ; microbiology ; pathology ; surgery ; Staphylococcus aureus ; isolation & purification ; Young Adult

In order to enhance the survival rate of abalone larvae, antibiotic susceptibility tests were performed on the bacteria isolated from whitened postlarvae, biofilm and the pond water of abalone (Haliotis diversicolor superteta) and proven to be virulent pathogens by challenge tests. API tests indicated that the isolates were mainly comprised of Vibrio alginolyticus, vibrio cholerae, Vibrio parahaemolyticus, the total Vibrio number of which was seventeen and made up about 50% of the total population. Among vibrios, Vibrio alginolyticus was the dominant strain (11 isolates) and made up 70%. Antibiotic susceptibility tests demonstrated that while majority isolates exhibited relatively high sensitivities toward streptomycin, erythromycin and gentamycin, they nevertheless displayed resistance to tetracycline and novobiocin. Results clearly indicated that streptomycin, erythromycin and gentamycin could be potentially used to suppress vibrio growth and hence improve abalone postlarval survival rate.

Chronic Disease ; Heart Failure ; diagnosis ; Humans ; Medicine, Chinese Traditional

Aged ; Humans ; Male ; Palatal Neoplasms ; pathology ; Uvula ; pathology

The daily intake levels and trend of polychlorinated dibenzo-p-dioxins(PCDDs), polychlorinated dibenzofurans(PCDFs), polychlorinated biphenyls(PCBs) of general population of several developed countries are reviewed. Based on the data of China, PCDD-Fs levels in Chinese human milk and blood were less than that of other countries, in addition, a daily intake of PCDD-Fs for Chinese general population was estimated in the present paper, the tolerable daily intake of Chinese general population was less than that the World Health Organization proposed.

Objective To study the value of bone marrow MR imaging in mornitoring chronic myeloid leukemia(CML).Methods 12 cases of CML underwent twice MR examination of pelvis and femur respectively at different time.MRI appearances were compared with the results of morphology and blood routine at the same time.The relation between MR findings and course was analysed.Results MR appearances of bone marrow were changed with the progression of disease.The condition of patients was improved in 2 cases and worse in 4 cases,the signal intensity of bone marrrow were increased and decreased respectively.The signal intensity of bone marrow showed no change in 6 patients whose condition kept stable.Conclusion The characteristics of MRI can reflect the progression of CML,it is of important value in mornitoring this disease.

0.05).The amount of transfusion blood transfured was 514.7ml?172. 56ml.The amount of thoracic drainage was larger in transfusion group than that in no-transfusion group(P

Objective To explore the effect of hypoxia on the in vitro invasion of lung carcinoma cells and its molecular basis. Methods Small cell lung carcinoma cells(H128) were exposed to hypoxia(5%O 2,5%CO 2,90%N 2) or anoxia(95%N 2,5%CO 2)condition for 48 hours. The invasive ability of the cancer cells was assayed with HABM-HEM model. The expression of E-cadherin and ? 1-integrin on the cells was also assayed by flow cytometry. Results Compared with normoxia group, the invasive ability of the cancer cells increased, the expression of E-cadherin decreased, and the expression of ? 1-integrin increased in hypoxia group. In anoxia group, the invasive ability and the expression of E-cadherin and ? 1-integrin all decreased compared with normoxia group. Conclusions Moderate hypoxia can down-regulate the expression of E-cadherin, up-regulate the expression of ? 1-integrin, and increase the invasion of carcinoma cells. But serious hypoxia can decrease the expression of adhesive molecules and the invasion of the cancer cells.