Axilla ; Breast Neoplasms ; diagnosis ; pathology ; therapy ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; diagnosis ; Sentinel Lymph Node Biopsy

Abstract?AlM: To study the effect of Danggui Shaoyao Powder combined with trabeculectomy and bevacizumab on neovascular glaucoma? METHODS: Neovascular glaucoma patients were enrolled from January 2011 to February 2014 in our hospital, according to the different methods of treatment were divided into observation group given traditional Chinese medicine and Western medicine combined with trabeculectomy, and control group received Western medicine combined with trabeculectomy. Visual acuity, intraocular pressure, retinal thickness were compared.?RESULTS: Visual acuity level : 1wk; 6, 12mo after treatment, visual acuity in observation group were significantly higher than that in control group (0. 41±0. 07 vs 0. 27±0. 04, 0. 52±0. 08 vs 0. 38±0. 06, 0. 72±0. 14 vs 0. 54± 0. 08 ); lntraocular pressure: 1wk; 6, 12mo after treatment, intraocular pressure in observation group were significantly lower than that in control group (15. 11±3. 22 vs 22.32±5.34, 18.64±5.08 vs 26.67±6.22, 17.18±3.76 vs 22. 42 ± 4. 32 ) mmHg; Retinal nerve fiber layer thickness:12mo after treatment, nerve fiber layer thickness in observation group was significantly higher than that in control group (90. 41±10. 52 vs 78. 64±8. 24, 88. 38±12. 12 vs 72. 37± 8. 82, 73. 21 ± 8. 46 vs 60. 25 ± 7. 23, 75. 35 ± 8. 13 vs 62. 63±7. 29)μm.?CONCLUSlON:Danggui Shaoyao Powder combined with trabeculectomy and bevacizumab on neovascular glaucoma can promote visual acuity recovery, control intraocular pressure, and improve the retinal nerve fiber layer thickness.

Breast Neoplasms ; pathology ; surgery ; Endoscopy ; Female ; Humans ; Mastectomy ; adverse effects ; methods ; Neoplasm Metastasis

Objective:The purpose is to observe the clinical results of the continuous douche and negative pressure drainage technic in treating the large hypodermal infected lacuna. Methods: The simple mini-size perfusion cannula for continuous douche and negative pressure drainage was handmade and used on 23 patients suffering from large hypodermal infected lacuna. Results: All of the 23 patients achieved primary healing from large hypodermal infected lacuna. Conclusion:The use of self-made mini-size perfusion cannula for continuous douche accompanied with negative pressure drainage is a good method to treat large hypodermal infected lacuna. It is very economic、efficient and easy.

Objective To investigate the expression of sex hormone receptor (SHR) in meningioma and its relationships to the origin of tumor central artery.Methods The expressions of sex hormone receptors, including progesterone receptor (PR), androgen receptor (AR) and estrogen receptor (ER) in 43 cases with meningioma were detected by immunohistochemically streptavidin-peroxidase (SP) method. These data combined with the characteristics of digital subtraction angiography (DSA) were analyzed.Results The expression of ER in meningioma was not related to the origin of tumor central artery. The positive expression rates of PR and AR in external carotid artery (ECA) original group (26.9%,23.1%) were significantly lower than those in internal carotid artery (ICA) original group (88.9%,77.8%) and ECA combined with ICA group (87.5%,87.5%) (all P

Objective To review the recent studies on the suppressing function of breast cancer metastasis suppressor 1 (BRMS1) in breast cancer metastasis. Methods The recent literatures on the mechanisms of BRMS1 in the breast cancer that were published in and abroad were reviewed and summarized. Results BRMS1, similar to the other anti-metastasis genes, only suppresses the metastasis of breast cancer cells but has nothing to do with the growth of tumor. BRMS1 could suppress metastasis of tumor cells by reestablishing both the homospecific and the heterospecific gap junctional intercellular comminications (GJIC) and by altering the expressions of relevant metastasis genes in the breast cancer. Conclusion Further studies on BRMS1 may be helpful to understand the metastasis of breast cancer, which may provide a new way for the diagnosis and treatment of breast cancer.

Objective To investigate the effect of steroid receptor coactivator family in initiation, development, treatment and prognosis of breast cancer. Methods The literatures in recent years which have related to the effect of steroid receptor coactivators in breast cancer are reviewed. Results Steroid receptor coactivators are essential for several kinds of steroid hormones binding to steroid receptors, so they are important accessory factors that induce the initiation, development and recurrence of breast cancer, and predictive factors that estimate the prognosis of breast cancer. Conclusion Inhibition of the expression and signaling pathway of steroid receptor coactivators may be effective for breast cancer prevention and treatment.

Objective To review the recent studies about sentinel lymph node biopsy in breast cancer. Methods The literatures in recent years on the history, concept, technique and clinical application of sentinel lymph node biopsy were reviewed and summarized.Results There was no unified method for sentinel lymph node biopsy. There was a wide range of detection rate and false negative rate.Conclusion Prospective multi center random clinical trials will help to evaluate the clinical application of sentinel lymph node biopsy.

Objective:To observe whether murine bone marrow mesenchymal stem cells(MSCs)implantation improves the survival of hepatocellular carcinoma(HCC)-bearing mice,and to investigate whether MSCs can differentiate to hepatocytes in HCC microenvironment in a mouse model of orthotopic HCC and its effects on tumor cells.Methods:Murine bone morrow MSCs were obtained through adherent culture method combined with magnetic cell sorting CD45-,CD11b-cells,labeled with CFSE in vitro.Phenotypes of MSCs were analyzed by flow cytometry.A murine model of orthotopic HCC was induced by intrahepatic injection of 5?105 murine H22 hepatoma cells in a BALB/c mouse.In this experiment,twelve BALB/c mice were randomly divided into MSCs implantation and saline administration groups on the 7th day after establishment of orthotropic HCC.CFSE labeled MSCs were injected into tumor and/or normal liver tissue in MSCs implantation group.The life span of HCC-bearing mice was observed.After three weeks,albumin was determined by immunohistochemistry.The livers of HCC-bearing mice were observed by light microscopy.Results:In MSCs group,the mean survival time was 25 days(95%Confidence interval:22-28 d),while,in the control group,mean survival time was 21 days(95%CI:20-23 d).However,the statistical difference was not obvious between the two groups(P=0.0713).It showed that the CFSE labeled cells mainly localized in the border of tumor,also a few in the tumor bed,and expressed albumin.Interestingly,there was a larger area of necrosis in the tumor bed,compared with that in the controls.Conclusion:It can be concluded that MSCs not only could engraft in livers of carcinoma-bearing BALB/c mice,but also could differentiate to hepatocyte-like cell.At the same time,MSCs might induce tumor cells necrosis.Further mechanism need to be studied.

Objective To review recent studies on the research advance of the relationship between RET proto-oncogene and differentiated thyroid carcinoma. Methods The literatures in recent years on the structure of RET gene and coding product,cell signal transduction,relationship between RET proto-oncogene and differentiated thyroid carcinoma were reviewed.Results RET gene encoding tyrosine kinase receptor,involving in cell signal transduction,rearrangement of RET gene was frequently seen in papillary thyroid carcinoma.Conclusion Rearrangement of RET gene was closely correlated with the occurrence and progress of differentiated thyroid carcinoma,RET gene may be considered as a new therapeutic target for differentiated thyroid carcinoma.