With the rapid development of proteomics technology,SELDI protein chip technology has become a powerful tool for proteomics with the capacity of gathering sample separation,purification,testing and data analysis together.As its convenience,high-throughput and high-sensitivity,as well as simple and fast analysis,SELDI technology plays an important role in the diagnosis and prevention of tumor.Here we re- view the basic principles,features and recent advances of this technology in digestive tumor.

BACKGROUND:There is no consensus on the choice of anatomic plate or dynamic hip screw for the treatment of intertrochanteric fracture. Current research is limited to smal-sample studies, and it is difficult to carry out a large-sample multicenter analysis. OBJECTIVE:To carry out Meta-analysis about the literature on anatomic plate versus dynamic hip screw in the treatment of intertrochanteric fractures, in order to evaluate the efficacy of anatomic plate versus dynamic hip screw in the treatment of intertrochanteric fractures. METHODS:The PubMed database (1995-2013), EMCC database (1995-2013), CBM database (1995-2013), CNKI database (1995-2013), VIP database (1989-2013) and Wanfang database (1995-2013) were searched by computer to col ect the control ed trials of anatomic plate versus dynamic hip screw for the treatment of intertrochanteric fractures. Then, the retrieved studies were screened according to predefined inclusion and exclusion criteria. The quality of the included studies was evaluated to extract useful y data, and Meta-analysis was performed by using the RevMan5.0 software. RESULTS AND CONCLUSION:A total of 19 control ed trials were included with a total of 1 730 cases. Among them, 764 cases were belonged to the anatomic plate group, and dynamic hip screw group included 966 cases. The Meta-analysis results indicated that there were no statistical y significant differences in fracture healing time, prognosis excellent and good rate and postoperative complications between two groups (P=0.34, 0.58, 0.80);the operative time, intraoperative blood loss and postoperative drainage volume in the anatomic plate group were lower than those in the dynamic hip screw group (P<0.000 01). The results indicate that anatomic plate and dynamic hip screw have the similar clinical efficacy for the treatment of intertrochanteric fractures, but the anatomical plate has relatively simple operation and less bleeding. Due to the poor quality of the included literatures and high bias occur and influence the effect, so more wel-designed multi-center randomized control ed trials should be performed to provide high-quality evidence.

From the view of medical professionals, this paper explored the standards of residents′ competency cultivation in Zhuhai using Delphi method. The research outcome that consisted of 53 factors and 6 dimensions was obtained after two rounds of expert consultation. There are 6 first-level indexes including professionnalism and body-mind quality, clinical practice skill, the competency of lifelong learning and self-improvement, humanistic medicine practice skill, medical knowledge, and the competency of promoting the medical system to develop. As well, there are 18 second-level indexes and 29 third-level indexes. The standards stated that the clinical prac-tice skill would not be the main part of residents′competency cultivation. Qualified residents should reach the na-tional standard of the clinical practice skill but also the other five indexes.

OBJECTIVE: To explore a drug supply system to meet radiation accident.METHODS: According to the characteristics of drug utilization for radiation disease,a retrospective analysis was conducted on the drug demand and supply in the course of treating two patients with severe radiation disease.RESULTS: The characteristics of drug supply to meet demand of remedy of acute radiation sickness manifested as a great variety and wide scope of drugs involved and purchase without scheme because of uncertainties of dosages and course of treatment,and the time is urgent,and the drug supply is more difficult.Great importance should be attached to the reserving of drugs,information,capability,and pre-draft in building and operating the drug supply system to meet radiation accident.CONCLUSION: To build a drug supply system to meet radiation accident,reasonable organization and utilization of drugs resources is quite necessary.

Objective To explore the clinical application value of multi-slice spiral CT angiography.Methods 28 patients who were suspected cerebrovascular disease were taken cerebrovascular enhanced scan by 16-slice spiral CT,and VR,MIP and MPR post -processing were uset to reconstmct the cerebrovascular image.Results In 28 patients,11 cases were normal,17 cases were abnormal,and among these patients there were 8 cases of abnormal blood vessels,4 cases of aneurysms,1 case of cerebral arteriovenous malformation,4 cases of cerebral artery stenosis.Conclusion The multi-slice CT compared with ordinary spiral CT had the advantage of faster and more secure.It had an important role in guiding the screening and clinical treatment programs in cerebral infarction patients with suspected cerebral artery stenosis.It had a lot of advantages in diagnosis vascular disease and clinical observation after treatment.

Objective To explore the curative effect of endourological treatment of pediatric urethral hemangioma with holmium laser.Methods Two children with urethral hemangioma were enrolled in this study. One urethral hemangioma in the bulbous urethra,another in the posterior urethra. Modalities of diagnosis before operation included B ultrasound,intravenous urogram(IVU) and endoscopy. Two children with urethral hemangioma underwent holmium laser therapy.Results After endourological trearment with holmium laser, two children had been cured.Six months to 4 years follow-up did not find recurrent urethral hemangioma.Conclusions The diagnosis of pediatric urethral hemangioma mainly rely on endoscopy. Endourological treatment with holmium laser is a minimally invasive,safe and effective methods for pediatric urethral hemangiomas.

Objective To investigate the effect of multidisciplinary intervenient on survival of patients with malignant tumor. Methods Six hundred and thirty-nine malignant tumor patients were randomly assigned to the intervenient and the control group. A total of 584 completed the follow-up study. The intervenient group received comprehensive treatment for 2 years,while the control group was in a process of self-rehabilitation. The 2-year survival rate was compared between the groups by using Cox proportional hazard model. Results The 2-year survival rate was 94. 74% (108/114) or 80. 67% (121/150) in II stage patients of the intervenient or control group, respectively ( P < 0. 01 ) . The 2-year survival rate was 88. 03% (163/177) or 82. 8% (184/222) in early and medium stage patients of the intervenient or control group,respectively(P <0. 01). Conclusion The multidisciplinary intervenient may help to improve the 2 year survival of early or moderate stage malignant tumors.

Antigens, CD ; metabolism ; B7-1 Antigen ; metabolism ; CD28 Antigens ; metabolism ; CTLA-4 Antigen ; Child ; Humans ; Interleukin-2 ; metabolism ; Mucocutaneous Lymph Node Syndrome ; immunology ; metabolism ; RNA, Messenger ; genetics ; Receptors, Immunologic ; metabolism

Objective:To analyze the secular trends of height among Chinese students aged 17 in dif-ferent ethnic minorities from 1985 to 2010. Methods:A total of 18 Chinese ethnic minorities’ students, including Mongolian, Hui, Uygur, Zhuang, Korean, Tibetan, Miao, Buyi, Dong, Bai, Tujia, Hani, Dai, Lisu, Wa, Nakhi, Tu and Qiang as subjects were sampled from the 1985, 1995, 2000, 2005 and 2010 Chinese National Surveys on Students’ Constitution and Health. The heights of 17 years old people by gender in various ethnic minorities were analyzed and compared. Results:From 1985 to 2010, the in-crements of adult heights increased significantly in many ethnic minorities’ boys. In 2010, the average height of boys aged 17 years in each minority group was higher than 162 cm and was higher than 170 cm among boys from Hui, Mongolian and Korean groups. The ethnics with height growth rates of more than 2 cm per decade in boys were Hui (2. 64 cm/decade) and Dong (2. 05 cm/decade) and the ethnics with height growth rates of more than 1 cm per decade were Korean (1. 99 cm/decade), Tibetan (1. 90 cm/decade), Hani (1. 80 cm/decade) and the other 9 minority groups. The average height of girls aged 17 years in each minority group was higher than 150 cm in 2010 . The heights showed an upward trend in 15 minority groups, but with different degrees. The ethnics with height growth rates of more than 1 cm per decade were Hui (1. 56 cm/decade) and Korean (1. 29 cm/decade). The increments that were signifi-cant between 1985 and 2010 were Hui (3. 89 cm), Korean (3. 23 cm), Dong (2. 35cm) and the other 6 minority groups ( P<0 . 05 ) . Conclusion: Our data suggest that the increments of adult heights may reflect the secular growth change in the major minority groups during the past 25 years, but there was an obvious disequilibrium among various ethnic minorities. We should pay more attention to the minority groups with poor growth and give them more help. Meanwhile, we should also pay attention to the nega-tive effects of the secular growth trend on those minority groups with fast increasing adult height.

Objective:To analyze the current situation of age at menarche ( AAM) in Chinese ethnic minority girls aged 9 -18 years, and compare the AAM with that of Chinese Han girls from the same province or autonomous region .Methods:Probit analyses were used to calculate the AAM in various eth-nic minority groups of Chinese girls who participated in 2010 National Physical Fitness and Health Sur-veillance .The sample size of ethnic minority girls was 31 711, and the ethnic minorities were Mongolian , Hui, Tibetan, Uighur, Miao, Yi, Zhuang, Buyi, Korean, Dong, Yao, Bai, Tujia, Hani, Kazak, Dai, Li, Lisu, Wa, Shui, Dongxiang, Naxi, Kirgiz, Tu, Qiang and Sala.The local Han girls to compare with the AAM were also surveyed in 2010 National Physical Fitness and Health Surveillance .Results:In the 13-year-old group, the percentage of menarche in Sala was the lowest (32.17%), while that in Korean was the highest (93.23%).At the age of 18, 99.60%ethnic minority girls appeared menstruating .The AAM of the top 3 ethnic minority groups were Korean ( 11 .79 years ) , Mongolian ( 12 .44 years ) and Zhuang (12.52 years); and the last 3 ethnic minority groups were Dongxiang (14.36 years), Sala (14.32 years) and Shui (14.02 years).The AAM in Korean was 0.93 years earlier than that of the Han girls from Jilin province;the AAM in Mongolian was 0 .14 years earlier than that of the Han girls from Neimenggu autonomous region;the AAM in Naxi and Qiang was close to that of the Han girls in the same province (region) (P>0.05);and the AAM in Hui, Uighur, Miao, Yi, Zhuang, Buyi, Dong, Yao, Bai, Tujia, Hani, Kazak, Dai, Li, Lisu, Wa, Shui, Dongxiang, Kirgiz, Tu, and Sala was later than that of the Han girls in the same province ( region) .The cluster analysis indicated that the 26 ethnic mi-nority groups could be classified as three groups: Korean were classified into the earlier age group of AAM;Dongxiang, Sala, Uighur, Yi and Shui belonged to the later age group of AAM;and the other 20 ethnic minority groups were into the middle age group of AAM .Conclusion:There was a large variation among different ethnic minority groups in China .The AAM was earlier in Korean , and Mongolian , com-pared with the local Han girls , and the AAM in other ethnic minority groups was the same or later com-pared with the local Han girls .