To observe the effect of "Yixintang" on the protection of the myocardium against ischemia reperfusion injury. Thirty Wistar rats, with their hearts isolated, were randomly divided into three groups: Yixintang group 1 (YXT1, with 0 01g "Yixintang" in each ml K H fluid), Yixintang group 2 (YXT2, with 0 1g "Yixintang" in each ml K H fluid) and control group. Left ventricular systolic output pressure (LVSP), rate of rise of left ventricular pressure (?dp/dt max ), left ventricular end diastolic pressure (LVEDP), heart rate, the content of malondialdehyde(MDA) in myocardial tissue were measured. The results showed that cardiac functions seemed to recover well after ischemia reperfusion injury in the group 2. The values of myocardial dynamics and hemodynamics indexes, including LVSP and ?dp/dt max , in the group 2 were obviously higher than those in the control group after ischemia reperfusion. The content of MDA in myocardial tissue was obviously lower in the group 2 than in the control group after ischemia and reperfusion. There was significant difference between Yixintang group 2 and control group ( P

In the undergraduate teaching assessment,"eaching quality control" is the core content of their inspection.This paper explained the quality control of the content,analyzed the challenge of improving the teaching quality and put forward the idea of constructing the perfect teaching quality control system from five aspects such as raising awareness and unifying thinking,establishing a sound teaching system,strengthening the organizational functions and responsibilities,grasping the key points and implementing the whole process of the quality control.

Objective To compare the effects of total intravenous anesthesia(TITA) by using remifentanil combined with propofol and intravenous-inhaled anesthesia by using propofol combined with sevoflurane on emergence agitation(EA) in children undergoing surgery of obstruction sleep apnea syndrome(OSAS). Methods Forty children of 3 to 7 years old scheduled for elective surgery of OSAS were randomly divided into TITA group(group T,n=20) and combined anesthesia group(group C,n=20).Patients in group T were induced with remifentanil 1 ?g/kg,midazolam 0.2 mg/kg,propofol 2.5 mg/kg and rocurolnium 0.6 mg/kg and maintained with remifentanil(0.4-0.5 ?g?kg-1?min-1) and propofol(4-6 mg?kg-1?h-1) until the end of the operation.Patients in group C were induced with midazolam 0.2 mg/kg,propofol 2.5 mg/kg and rocurolnium 0.6 mg/kg and maintained with propofol 4-6 mg?kg-1?h-1 and sevoflurane inhalation(1.2-1.4 MAC) until the end of the operation.EA was evaluated by 5-point scoring scale. Results The score of EA was significantly lower in group T than that in group C(P

BACKGROUND:There is no consensus on the choice of anatomic plate or dynamic hip screw for the treatment of intertrochanteric fracture. Current research is limited to smal-sample studies, and it is difficult to carry out a large-sample multicenter analysis. OBJECTIVE:To carry out Meta-analysis about the literature on anatomic plate versus dynamic hip screw in the treatment of intertrochanteric fractures, in order to evaluate the efficacy of anatomic plate versus dynamic hip screw in the treatment of intertrochanteric fractures. METHODS:The PubMed database (1995-2013), EMCC database (1995-2013), CBM database (1995-2013), CNKI database (1995-2013), VIP database (1989-2013) and Wanfang database (1995-2013) were searched by computer to col ect the control ed trials of anatomic plate versus dynamic hip screw for the treatment of intertrochanteric fractures. Then, the retrieved studies were screened according to predefined inclusion and exclusion criteria. The quality of the included studies was evaluated to extract useful y data, and Meta-analysis was performed by using the RevMan5.0 software. RESULTS AND CONCLUSION:A total of 19 control ed trials were included with a total of 1 730 cases. Among them, 764 cases were belonged to the anatomic plate group, and dynamic hip screw group included 966 cases. The Meta-analysis results indicated that there were no statistical y significant differences in fracture healing time, prognosis excellent and good rate and postoperative complications between two groups (P=0.34, 0.58, 0.80);the operative time, intraoperative blood loss and postoperative drainage volume in the anatomic plate group were lower than those in the dynamic hip screw group (P<0.000 01). The results indicate that anatomic plate and dynamic hip screw have the similar clinical efficacy for the treatment of intertrochanteric fractures, but the anatomical plate has relatively simple operation and less bleeding. Due to the poor quality of the included literatures and high bias occur and influence the effect, so more wel-designed multi-center randomized control ed trials should be performed to provide high-quality evidence.

Objective A comprehensive evaluation of the quality of medical service from January to December in 2007 was conducted in order to provide scientific policies for far-flung work and create bigger benefit in a certain hospital. Methods Apply factor analysis ascertains the weight,and we carry through a comprehensive evaluation of the quality of medical service combine with weighted TOPSIS to the hospital. Results The quality of medical service of hospital in 2007. The months of April,July , November better; February,May, October worse. The results accord with reality. Conclusion Research shows comprehensive evaluation of hospital medical quality needs a scientific target system. Using factor analysis and combining weighted TOPSIS in comprehensive evaluation is more objective and more scientific and authentic as take full advantage of the original source.

Leber's hereditary optic neuropathy (LHON) is an inherited mitochondrial disorder characterized by bilateral progressive vision loss.Current management includes therapies directed at enhancing mitochondrial function and preventing oxidative damage.This article reviews the progress of treatments from mitochondria cocktail,idebenone,gene therapy,EPI-743,brimonidine,traditional Chinese medicine and physical therapy,providing a new insight in the treatments of LHON.

Objective To observe the protective effect of Yixintang on injury of myocardial ischemia-reperfusion with isolated working heart. Method 40 mice are randomly divided into 5 groups:control group, Yixintang group 1, Yixintang group 2, Yixintang group 3 and Verapamil group. The change of left ventricular systolic output pressure (LVSP), rate of rise left ventricular pressure (?dp/dtmax), left ventricular end diastolic pressure (LVEDP), heart rate, as well as the contain of malondialdehyde (MDA) release and activity of superoxide dismutase (SOD) were measured as investigate indicator. Results After ischemia and reperfusion in Yixintang group, the heart can be good recovery its function. The values of myocardial dynamics and hemodynamics indexes LVSP and ?dp/dtmax, in Yixintang group 3 and Verapamil group the indicator were obviously higher than those in the control group, after ischemial and reperfusion. The content of MDA in myocardial tissue in Yixintang group 3 and Verapamil group after ischemia and reperfusion was obviously lower than in other groups. It also could depress the activity of SOD, there was significant difference among Yixintang group 3, Verapamil group and control groups (P

OBJECTIVE:To comparison the clinical efficacy and safety of sitagliptin and Repaglinide in the treatment of new-ly diagnosed patients with type 2 diabetes mellitus. METHODS:214 newly diagnosed patients with type 2 diabetes mellitus were randomly divided into study group and control group with 107 cases in each group according to random number table method. Both group received routine diabetes diet,health education and suitable exercise. Control group was treated with Repaglinide tablet 1.0 mg,tid;while study group was treat with Sitagliptin tablet 100 mg,qd. Lab indexes,FBG,PBG,HbA1c and BMI were observed in 2 groups before and after treatment. ADR were compared between 2 groups. RESULTS:There was no statistical significance in lab indexes between 2 groups before and after treatment (P>0.05). After treatment,FBG,PBG,HbA1c were significantly de-creased significantly in 2 groups,with statistical significance (P<0.05),there was no statistical significance between 2 groups (P>0.05). BMI of 2 groups were increased significantly,and the study group was higher than the contrd group,with statistical sighificance (P<0.05). Patients in the study group had no hypoglycemia,while 3 patients in the control group suffered from it, there was statistical significance (P>0.05). CONCLUSIONS:Sitagliptin is similar with repaglinide in therapeutic efficacy;both can effectively reduce blood glucose of elderly patients with newly diagnosed type 2 diabetes mellitus,and the incidence of hypo-glycemia was low,the saterty was good,but sitagliptin has a better control of BMI in patients.

OBJECTIVEThis work lays the foundation for establishing a digital model database with normal occlusion. A digital dental cast is acquired through grating projection, and model features are measured through reverse engineering.

METHODSThe grating projection system controlled by a computer was projected onto the surface of a normal dental model. Three-dimensional contour data were obtained through multi-angle shooting. A three-dimensional model was constructed, and the model features were analyzed by using reverse engineering. The digital model was compared with the plaster model to determine the accuracy of the measurement system.

RESULTSThe structure of three-dimensional reconstruction model was clear. The digital models of two measurements exhibited no significant difference (P > 0.05). When digital and plaster models were measured, we found that the crown length and arch width were not statistically different (P > 0.05), whereas the difference between the crown width and arch length was statistically significant (P < 0.05).

CONCLUSIONThe reconstruction of a digital model by using the grating projection technique and reverse engineering can be used for dental model measurement in clinic al and scientific research and can provide a scientific method for establishing a digital model database with normal occlusion.

Objective To investigate the effect of multidisciplinary intervenient on survival of patients with malignant tumor. Methods Six hundred and thirty-nine malignant tumor patients were randomly assigned to the intervenient and the control group. A total of 584 completed the follow-up study. The intervenient group received comprehensive treatment for 2 years,while the control group was in a process of self-rehabilitation. The 2-year survival rate was compared between the groups by using Cox proportional hazard model. Results The 2-year survival rate was 94. 74% (108/114) or 80. 67% (121/150) in II stage patients of the intervenient or control group, respectively ( P < 0. 01 ) . The 2-year survival rate was 88. 03% (163/177) or 82. 8% (184/222) in early and medium stage patients of the intervenient or control group,respectively(P <0. 01). Conclusion The multidisciplinary intervenient may help to improve the 2 year survival of early or moderate stage malignant tumors.