No abstract available.
Humans ; Male* ; Nervous System*

No abstract available.

No abstract available.
Erectile Dysfunction* ; Male

Although platelet have been implicated in the pathogenesis of the thrombotic disease, the platelet aggregability was not well studied in Korea. Author measured platelet aggregability in 103 clinical cases including 30 healthy volunteers to evaluate the platelet function and the effect of Aspirin and Dipyridamole on aggregability in Korean. 24 patients with cerebral thrombosis, 24 patients with ischemic heart disease and 25 patients with hypercholesterolemia were included for this study. Aggregation tests were performed at three final concentrations of epinephrine(10microM/L) and ADP(4 microM/L, 10 microM/L) with platelet aggregometer which was made by Chrono-Log Corp. in all cases. Platelet aggregations were measured in patients who were treated with Aspirin, Dipyridamole and combined treatment of Aspirin and Dipyridamole respectively. The following results were obtained. 1) The mean maximal platelet aggregability in the normal subjects induced by 10 microM/L epinephrine was 59.3+/-24.26%, 66.6+/-14.00% in Bm and 62.5+/-19.30% in B5 in induction by 4 microM/L ADP, and 77.2+/-8.99% in Bm and 76.6+/-9.83% in B5 in induction by 10microM/L ADP. 2) The mean maximal platelet aggregability in patients with cerebral thrombosis induced by 10 microM/L epinephrine was 89.2+/-7.33%, 78.8+/-9.41% in Bm and 78.5+/-9.93% in B5 in induction by 4 microM/L ADP, and 86.4+/-7.69% in Bm and B5 in induction by 10 microM/L ADP. The results showed significantly elevated platelet aggergability than that of normal subjects(p<0.01). 3) The mean maximal platelet aggregability in patients with ischemic heart disease induced by 10 microM/L epinephrine was 88.1+/-11.99%, 78.2+/-12.50% in Bm and B5 in induction by 10 microM/L ADP. The results showed significantly elevated platelet aggregability than that of normal subjects(P<0.01). 4) The mean maximal platelet aggregability in patients with hypercholesterolemia induced by 10 microM/L epinephrine was 86.8+/-15.99%, 82.7+/-11.19% in Bm and 82.0+/-12.87% in B5 in induction by 4 microM/L ADP, and 88.5+/-11.47% in Bm and B5 in induction by 10 microM/L ADP. The results showed signifcantly elevated platelet aggregability than that of normal subjects(P<0.01). 5) The mean maximal platelet aggregability in patients with thrombotic disease was studied by Dipyridamole administration. The platelet aggregability induced by epinephrine before administration was 90.9+/- 8.52% and after administration it was 78.9+/-15.68%, and the results showed that Dipyidamole lowered aggregability significantly. The platelet aggregability induced by 4 microM/L ADP before administration was 84.0+/-11.90% in Bm and B5 and after administration it was 78.0+/-11.44% in Bm and B5, and the results showed that Dipyridamole lowered aggregability but not significant. The platelet aggregability induced by 10 microM/L ADP before administration was 89.2+/-10.39% in Bm and B5 and after administration it was 80.5+/-8.44% in Bm and B5, and the results showed that Dipyridamole lowered aggregability significantly. 6) The mean maximal platelet aggregability in patients with thrombotic disease was studied by Aspirin administration. The platelet aggregability induced by epinephrine before administration was 91.0+/-4.79% and after administration it was 47.6+/-17.72%. The platelet aggregability induced by 4 microM/L ADP before administration was 84.6+/-10.37% in Bm and B5 and after administration it was 72.6+/-11.85% in Bm and 65.3+/-15.97% in B5. The platelet aggregability induced by 10 microM/L ADP before administration was 84.9+/-6.30% in Bm and B5 and after adminstration it was 77.7+/-8.60% in Bm and 75.0+/-8.89%. The results showed that Aspirin lowered aggregability markedly. 7) The mean maximal platelet aggregability in patients with thrombotic disease was studied by combined administration of Aspirin and Dipyridamole. The platelet aggregability induced by epinephrine before administration was 86.7+/-13.77% and after administration it was 36.7+/-14.01%. The platelet aggregability induced by 4 microM/L ADP before administration was 81.5+/-12.93% in Bm and 80.6+/-14.15% in B5 amd after administration it was 54.7+/-17.27% in Bm and 44.6+/-21.17% in B5. The platelet aggregability induced by 10 microM/L ADP before administration was 87.8+/-10.11% in Bm and B5 and after administration it was 65.7+/-13.59% in Bm and 62.0+/-16.42% in B5. The results showed that combined administration of Aspirin and Dipyridamole lowered aggregability significantly and the results were lower than that of normal subjects. 8) The effects of combined treatment of Aspirin and Dipyridamole showed marked reduction of platelet aggregability than that of single treatment of Aspirin or Dipyridamole in thrombotic disease.
Adenosine Diphosphate ; Aspirin* ; Blood Platelets* ; Dipyridamole* ; Epinephrine ; Healthy Volunteers ; Humans ; Hypercholesterolemia* ; Intracranial Thrombosis ; Korea ; Myocardial Ischemia

No abstract available.
Animals ; Male ; Penile Erection* ; Rats* ; Saponins*

No abstract available.

To investigate role of autonomic nerves on penile erection and to further characterize the laboratory rat as animal model of penile erection, this experiment was performed by means of monitoring intracavernosal pressure following nerve stimulation in 46 rats. The results obtained were summarized as follows: Increased intracavernosal pressure as well as erection was observed following electrical stimulation( 1-10 volt, 0.5-5 Hz) on each autonomic nerve, although the hypogastric nerve required higher intensity of electrical stimuli than the parasympathetic nerve (pelvic or cavervnous nerve) to induce erectile response. Combined stimulation of the pelvic nerve and the hypogastric nerve resulted in synergistic increase of intracavernosal pressure. These results indicate the hypogastric nerve may have a potential role in mediation of penile tumescence as the parasympathetic(pelvic or cavernous) nerve and that this rat model would contribute to the further study of penile erection.
Animals ; Autonomic Nervous System ; Autonomic Pathways* ; Male ; Models, Animal ; Negotiating ; Penile Erection* ; Rats*

No abstract available.
Herpes Zoster*

The Bulbocavernous reflex is important in the neurological evaluation of patients with impotence or neurogenic bladder. Classically, this reflex has been elicited and estimated by manual stimulation of glans penis or clitoris. However, it is extremely subjective and minimal degrees of neuronal dysfunction cannot be detected. We have applied electrophysiologic testing technique to quantitative this reflex more objectively and to prepare normal data for the pathologic states. There were 15 adult male subjects without erectile disturbance and neuronal dysfunction studied by the electromyographic testing technique. The stimuli were delivered to the ipsilateral and contralateral penile shaft with a frequency of 1/sec., a pulse duration of 0.5 msec. and averaging of 64. The Results obtained were summarized as follows: 1. Mean BCR latency was 35.6+/-1.6 msec. (28-45 msec.), and showed no statistical difference(p>0.5) among the value of different age groups. Ipsilateral and contralateral responses varied from each other by not > 2 msec. 2. Mean sensory threshold was 20 V (15-25 V), and showed no statistical difference(p>0.5) among the values of different age groups. 3. Mean pain threshold was 45 V (35-80 V), and showed no statistical difference(p>0.5) among the values of different age groups. 4. Mean reflex threshold was 40 V (30-60 V), and showed no statistical difference(p>0.5) among the values of different age groups. 5. In entire age groups, the latency diminished slightly as the stimulating voltage was increased.
Adult* ; Clitoris ; Erectile Dysfunction ; Female ; Humans ; Male* ; Neurons ; Pain Threshold ; Penis ; Reflex* ; Sensory Thresholds ; Urinary Bladder, Neurogenic

Studies on nocturnal penile tumescence characteristics in normal men have advantages of further investigations of erection physiology and of impotence research. We conducted a study of nocturnal penile tumescence in 30 Korean healthy males aged 21 to 68 (divided into 5 groups, from 20s to 60s) by means of polysomnographic monitoring to provide normative data on how it is related to man`s sexual function with aging and its range of characteristics for the management of impotence. Analyses of 60 sleep data showed that with aging from 20s to 60s, there was steady decrease in mean values of total tumescence time, total tumescence time/total sleep period time, total tumescence time/total REM period time, amount of maximum REM-related tumescence episodes, frequency of REM-related tumescence, frequency of maximum REM-related tumescence episode, as well as of penile circumferential change and penile rigidity in maximum tumescence episode. These results indicate that there is steady decrease in the quality of nocturnal penile tumescence including frequency, duration, amount and degree with aging from 20s to 60s, which reflects changes of sexual capacity and function in psychosexul aspect. We suppose these normative data will contribute to further clinical investigations of nocturnal penile tumescence and male sexual dysfunction.
Adult* ; Aging* ; Erectile Dysfunction ; Humans ; Male ; Penile Erection* ; Physiology