Objective To study the correlationship among plasma lipoprotein associated phospholipase A2 (Lp-PLA2),hypersensitive C reactive protein (hs-CRP) and D-dimer levels of coronary heart disease (CHD) patients.To evaluate their relationship and prognostic values.Methods Case control study.This study enrolled 150 CHD patients,130 age and gender compared health control.The clinical data were recorded and plasma Lp-PLA2,hs-CRP and D-dimer were test.Lp-PLA2 was test by enzyme kinetics method,hs-CRP and D-dimer were test by immunonephelometry method.The blood were also test low density lipoprotein cholesterol and myocardial injury markers such as troponin I,myoglobin,creatin kinase MB.The numbers of lesion coronary arteries were confirmed by percutaneous coronary intervention operation.Student t-test and mann-whitney U test were used to compare two groups datas,analysis of variance was used to compare more than three groups datas,spearman test was used for correlationship analysis between groups.Results The Lp-PLA2,hs-CRP and Ddimer of CHD group were (43.62 ±13.23) g/L,5.09 mg/L(95％ CI:0.56-74.15),173.0 mg/L(95％ CI:103.0-966.5),respectively.They were higher than healthy control group whose values were (21.49 ± 7.63)g/L,2.61 mg/L(95 ％ CI:0.37-45.12),68.0 mg/L (95％ CI:48.0-540.6),respectively.The difference were statistical significant (t =2.69,U =67.52,U =37.84,P ＜ 0.001).After correlation with clinical data,the Lp-PLA2 was correlated to LDL(r =0.487,P ＜ 0.001) and the numbers of coronary artery lesion (r =0.260,P =0.018).D-dimer was correlated to hs-CRP(r =0.263,P =0.011),it was also correlated to NYHA heart function level (F =23.78,P =0.001).Conclusions Lp-PLA2 is important in lipid metabolize,especially in LDL metabolize.Lp-PLAz can be used to predict severity of coronary artery lesion.Hs-CRP correlated to D-dimer level and cardiac injury markers.It stated link between inflammation and thrombosis.D-dimer is increasing with NYHA level.Lp-PLA2,hs-CRP and D-dimer are correlated to coronary artery lesions,they are good prognostic indices for coronary heart disease patients.

The cardiovascular and cerebrovascular diseases have become a main category of disease which affects human health today.It is helpful to search for its causes and main risk factors for scientific prevention and control of these diseases.Now,we have already paid close attention to effect of the airborne contaminant and meteorological factors on the cardiovascular and cerebrovascular diseases.Some reports about solo affect of two types factors have given a clear results;however,a little of unification evidences have been provided.This article reviews the solo and unification effects of pollutants and meteorological factors in the cardiovascular and cerebrovascular diseases.

Adult ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; Peripheral Vascular Diseases ; drug therapy ; Phytotherapy ; Takayasu Arteritis ; drug therapy

AIM:To compare the therapeutic effect，adverse reactions and the costs between GM-CSF and G-CSF in treating leucopenia in chemotherapy of cancer.METHODS:Using pharmacoeconomic cost-effectiveness analysis，GM-CSF was compared with G-CSF in treatment of leucopenia in chemotherapy of cancer.RESULTS:The effective rate of GM-CSF was 80％ with an average cost of 1 008 yuan in a therapeutic course，the cost-effective ratio being12.6，and that of G-CSF was 85.7％ with an average cost of 2 304 yuan，the cost-effective ratio being 26.88.CONCLUSION:GM-CSF can effectively treat leucopenia in chemotherapy of cancer，and its cost-effective ratio ia superior to that of G-CSF.GM-CSF is worthy to be used clinically.

AlM:To investigate biological measurement parameters of anterior segment in acute angle- closure glaucoma ( AACG) .METHODS:Forty-six eyes of 46 patients with AACG and 52 eyes of 52 patients with shallow anterior chamber and 50 eyes of 50 normal individuals were examined. The parameters of anterior segment including chamber crowd rate (CCR), lens thickness (LT), lens position (LP) and anterior chamber depth ( ACD ) were measured by A-ultrasound according to different ages in each group. The data were performed statistical analysis in three groups.RESULTS: ln each age range group (≥50 ~ 59 years old, ≥60 ~ 69 years old, ≥70 years old ) , statistically significant differences in three groups ( AACG, shallow anterior chamber group and the controls ) were found in CCR, LT, LP, ACD (P<0. 01). There were statistically significant differences only in CCR (P<0. 01) but not in LT, LP and ACD ( P > 0. 05 ) between AACG and shallow anterior chamber group in each age range group.CONCLUSlON: CCR can be used as the index of evaluating crowding state of anterior segment in AACG patients and the sensitivity is better than LT and LP.

?AlM: To evaluate the long - term effects of laser peripheral iridectomy ( LPl ) and trabeculectomy in treating early chronic angle-closure glaucoma.
?METHODS: Ninety-eight patients (102 eyes) with early chronic primary angle-closure glaucoma were randomly divided into two groups. Group A of 50 patients (54 eyes) was treated with LPl and group B of 48 patients (48 eyes) with trabeculectomy. After 3 - 8y of follow - up observation, comparison would be made from the perspectives of postoperative eyesight, intraocular pressure, anterior chamber angle, visual field and cup/disc ratio ( C/D) .
?RESULTS:ln group A, 24 eyes with eyesight declining, 22 eyes with theintraocular pressure>21mmHg (1mmHg=0. 133kPa), 21 eyes with chamber angle synechia >180o, 21 eyes with visual field narrowed, 21 eyes with C/D ratio enlarged. The results of group B for the same items were 10, 5, 4, 4, 4 eyes respectively. The comparative difference was statistically significant (P<0. 05).
?CONCLUSlON:Good effects will be achieved for early-stage chronic angle - closure glaucoma with surgical method. Trabeculectomy is obviously better than LPl for the long-term effects.

Corneal endothelial cell(CEC)is the most critical part for the cornea, of which activity can influence the postoperative vision.It is very important for the clinical cornea preservation considering the function and its self-purification of donor cornea.There are a variety of classical methods, which can significantly prolong the saving time of donor cornea with its good quality of CEC.We reviewed the published papers about present preservation methods of cornea, which can give us many suggestions for the clinical cornea preservation.

In this paper 3 different media (A,for yeast cultivation ; B, for laccase producing; D, for white rot fungi cultivation) were compared in enriching and screening decolorizing fungi culture using Reactive Black 5 (RB5) and Reactive Red (M-3BE) from the following three points: decolorization effects, abilities of producing enzymes and diversity of microbial community. 11 groups of fungi with obvious decolorization effects were obtained after enrichment for near one month. Among them, 6 groups came from medium D, the other two 3 groups from medium A and B, respectively. However, the 3 groups from medium A exhibited the highest microbial diversity and best decolorization results with 99.53% and 97.42% color removal rate of Reactive Red M-3BE and Acid Red. From them, 16 strains of fungi were isolated and primarily identified as Saprolegniaceae, Eurotiaceae (Monascus went), Erysiphaceae and Physodermataceae. Fungi groups from medium B and D exhibited a bit lower color removal rate of various dyes and only 3 and 2 isolates primarily classified as Saccharomycetaceae and Eurotiaceae (Penicillium) were obtained from them. Fungi cultures in medium A and B could produce lignin peroxidase, and those in medium D could be detected higher activity of laccase. All the fungal cultures exhibited very weak activity of manganese dependant peroxidase.

Epidemiologic Research Design ; Sociology, Medical

In this paper, the action of suet oil in the preparation of self-assembled micelles of the active flavonoids in Epimedium in the simulated human environment was researched. Twelve suet oil samples were collected from different growing areas and different positions of sheep or goat to simulate the formation of micelles. Then the effects of the fatty acids in suet oil on the preparation of self-assembled micelles were studied furthermore. The results showed that the micelles had a dispersed state and spherical smooth surface. To compare the diameter, potential, encapsulation efficiency and drug loading of the 12 batches micelles, the micelles prepared by the suet oil from Qinghai were more stable and had a higher encapsulation efficiency. The fatty acids in suet oil could promote the formation of self-assembled micelles, but the whole suet oil had a better effect. Above all the study, we confirmed that the suet oil promoted the formation of self-assembled micelles of the flavonoids in Epimedium, it laid foundation for further research about increasing the efficacy of Epimedium and improved the absorption of the active flavonoids in Epimedium.
Animals ; Chemistry, Pharmaceutical ; methods ; China ; Drug Carriers ; chemistry ; Electric Conductivity ; Epimedium ; chemistry ; growth & development ; Fatty Acids ; chemistry ; Flavonoids ; chemistry ; Geography ; Goats ; Humans ; Micelles ; Oils ; chemistry ; Sheep