2.Cytomegalovirus-Associated Hemophagocytic Syndrome Diagnosed by Liver Biopsy in a Kidney Transplant Recipient
Eun Ji CHOI ; Su Hyung LEE ; Chang-Kwon OH ; Young Bae KIM ; Jun Bae BANG
Yonsei Medical Journal 2021;62(3):274-277
Hemophagocytic syndrome (HPS) is a rare but potentially life-threatening disease in kidney transplant recipients, and is caused by systemic proliferation of macrophages actively phagocytizing other blood cells in the bone marrow, lymph nodes, and the spleen.Here, we report a 40-year-old male kidney transplant recipient who presented with fever, bicytopenia, and elevated liver enzymes 2 months after transplantation. Given that cytomegalovirus antigenemia and real-time polymerase chain reaction tests were positive, liver biopsy was performed under an assumption of cytomegalovirus-induced hepatitis. Hepatic histology revealed multifocal microabscess with cytomegalovirus inclusion bodies, marked Kupffer cell hyperplasia, and erythrophagocytosis by activated macrophages. As laboratory findings such as hyperferritinemia, elevated serum lactate dehydrogenase, low natural killer cell activity, and high soluble interleukin-2 receptor were also compatible with HPS, the recipient was diagnosed as having cytomegalovirus-induced hepatitis combined with reactive HPS. Following intravenous ganciclovir therapy with continuous administration of tacrolimus and corticosteroid, the symptoms resolved and laboratory findings were normalized. As far as we know, this is the first report of cytomegalovirus-induced hepatitis combined with reactive HPS in a kidney transplant recipient that is diagnosed by liver biopsy.
3.Enrichment of flavonoid aglycones in licorice extract enhanced anti-inflammatory potential,but its hypnotic effect was not altered
Xue-Qiong ZHANG ; Hwa-Jin KIM ; Su-Ying CUI ; Tae-Jun BAE ; Xiang-Yu CUI ; Soo-Geun LEE ; Bae-Hyeong PYO ; Yong-He ZHANG
Chinese Journal of Pharmacology and Toxicology 2018;32(4):337-338
OBJECTIVE Licorice is used throughout the world as a traditional herbal remedy. Ac-cording to Chinese traditional medicine licorice alone can be used to treat inflammation.Although there have been some studies investigated the anti-inflammatory ingredients of licorice, but for the potency of flavonoid glycoside and their aglycones on inflammation are not evaluated.This study was designed to assess the contributions of licorice flavonoid glycosides and their aglycons to its anti-inflammatory and hypnotic effects. METHODS For the flavonoid aglycone's enrichment, the extract of licorice (EL) was fermented in submerged culture of the edible fungus Grifola frondosa HB0071 mycelia which can produce β-glucosidase and catalyze the flavonoid glycosides to aglycones.EL and fermented extract of licorice (FEL) were used in this study. The anti-inflammation test was carried out in arachidonic acid (AA)-induced ear edema model and the hypnotic test was performed by using electroencephalogram (EEG)analysis method in normal freely moving SD rats.The chemicals constituents were analyzed by HPLC.RESULTS During fermentation,the falvonoid glycosides of licorice were hydrolyzed by the time process.Along with fermentation time,the concentration of the major flavonoid glycosides,liquiritin and isoliquiritin were decreased obviously, and simultaneously their aglycons, liquiritigenin and isoliquiriti-genin were remarkably increased in FEL.Moreover,the content of another major constituent glycyrrhi-zic acid and glycyrrhetinic acid were not changed after the fermentation. In AA-induced mice ear ede-ma test,after topical application,FEL(effective dose range:5-20 μg·ear-1)showed more potent inhibito-ry activity than EL(effective dose range:25-100 μg·ear-1).On the other hand,oral administration of EL and FEL exhibited the same hypnotic potency and both enhanced the total sleep time including rapid eye movement (REM) sleep and non-REM sleep time. CONCLUSION These results suggested that the enrichment of flavonoid aglycons such as liquiritigenin and isoliquiritigenin enhanced the anti-inflam-matory potency of licorice extract,and this potentiation has nothing to do with glycyrrhizic acid or glycyr-rhetinic acid.In addition,enrichment of flavonoid aglycones did not alter the hypnotic effect of licorice.
4.A Case of Complete Agenesis of Corpus Callosum.
Jung Jun KIM ; Chul Su SHIN ; Chang Su YUN ; Sung Mi KIM ; Chang Su KIM ; Kook Howan BAE ; Jung Sil PARK ; Kwang Su HAN ; Jae Young JU
Korean Journal of Obstetrics and Gynecology 2003;46(7):1461-1465
The corpus callosum is the main interhemispheric connection in human brain. Agenesis of corpus callosum may partial or complete, and it may have not functional abnormalities. Its prenatal sonographic diagnosis is difficult because of fetal head position, especially in a cephalic presentation. We experienced a case of complete agenesis of corpus callosum. The prenatal sonographic findings was disproportionate dilatation of lateral ventricle, which were suggestive finding of agenesis of corpus callosum or hydrocephalus. We could confirm the diagnosis of complete agenesis of corpus callosum by postnatal MRI.
Agenesis of Corpus Callosum*
;
Brain
;
Corpus Callosum
;
Diagnosis
;
Dilatation
;
Head
;
Humans
;
Hydrocephalus
;
Lateral Ventricles
;
Magnetic Resonance Imaging
;
Ultrasonography
5.The relationship between intraoperative fluid management and postoperative adverse outcome in a orthognathic surgery
Jung ho LYOO ; Dai yun KIM ; Jun su BAE ; Byung eun YANG ; Jun yong YOU ; Yong gwan KIM
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2001;23(5):428-434
6.The characteristics and fates of pulmonary tuberculosis patients seen at medical department of a medium sized general hospital.
Young Hyo KIM ; Ki Chan PARK ; Seong BAE ; Sang Hun LEE ; Myung Ho CHUN ; Sang Ki LEE ; Kwang Su JUN ; Chan Se LEE
Tuberculosis and Respiratory Diseases 1992;39(5):417-424
No abstract available.
Hospitals, General*
;
Humans
;
Tuberculosis, Pulmonary*
7.Immediate provisionalization using one-piece narrow diameter implants for restoration of edentulous narrow spaces: Case reports.
Min Su BAE ; Jeung Uk HEO ; Jun Sub PARK ; Sun Hae YEA ; Kyung Mi AN ; Dong Seok SOHN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2009;35(4):276-279
The aim of this case study was to report the clinical outcome of immediate provisionalization using one-piece narrow diameter (3.0mm) implants in missing maxillary lateral or mandibular incisors. The present study included 36 patients who were treated with 62 one-piece narrow diameter implants. After implant placement, immediate provisional restorations were delivered. All implants showed favorable osseointegration and after progressive loading from 3 months to 9 months (average of 5 months), final restorations were completed without failure in all cases. A survival rate of 100 % (62 of 62) was observed up to 23 months of observation (average of 12.6 months).
Humans
;
Incisor
;
Osseointegration
;
Survival Rate
8.Recognition and behavior of family physicians working in private clinic on continuing medical education.
Sang Peel BAE ; Su Jin KIM ; Hong Jun CHO ; Ji Hyun AHN
Journal of the Korean Academy of Family Medicine 2001;22(12):1806-1813
BACKGROUND: Obligatory continuing medical education was applied by medical law for lifelong education to Physicians in Korea. A new method of continuing medical education was needed because of wide -spread and easy access to internet which resulted in improved public knowledge medicine, and appearance of a new internet site for doctor's continuing medical education. METHODS: A questionnaire was sent twice by mail and fax to randomly selected 256 office based family physicians in Seoul and Kyonggi Province in May 2001 and 124 available responses were received. RESULTS: The response rate to the questionnaire was 60.77, Median studying time Per week for the past one year of the responders was 3 hours and there was no significant correlation studying time per week with duration in practice, age, sex, or internet accessibility at clinic. The group with more than or equal to 6 years in duration of practice was significantly more than the group with less than or equal to 6 years in number of subscribing medical journals (P=0.001), number of participating academic conferences (P=0.027) , number of participating lectures for office based physicians (P=0.001) and points of formal continuing medical education (P=0.002). The practice pattern change after attendance was 51.3% in 5years or less in duration of Practice, 42.7% in 6years or more. Main causes of being reluctant to attend continuing medical education activities were'no practical content' and' long distance'. CONCLUSION: For the improvement of quality of care by continuing medical education, practical program applicable to the clinical practices should be developed and continuing medical education activities be carried out in various areas.
Congresses as Topic
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Education
;
Education, Medical, Continuing*
;
Gyeonggi-do
;
Humans
;
Internet
;
Jurisprudence
;
Korea
;
Lectures
;
Physicians, Family*
;
Postal Service
;
Seoul
;
Surveys and Questionnaires
9.The Operation of Acute Epidural Hematoma Through Small Craniotomy: Technical Note.
Seung Kyu PARK ; Jun Seob LIM ; Gyung Bae SONG ; Yong Su KIM ; Sin Gil YIM ; Kyu Yong CHO
Journal of Korean Neurosurgical Society 2003;33(1):108-110
We introduce a new operative method for acute epidural hematoma(AEDH) through small craniotomy. Between January 1999 and December 2001, 63 patients underwent craniotomy in our hospital to evacuate an acute posttraumatic epidural hematoma. Among these, we operated 18 patients with linear scalp incision and about 4 X 4cm sized small craniotomy. After operation, neurological symptoms were improved and there were no significant postoperative complications in all patients. This operative method is simple and less time consuming. It can be done under the local anesthesia and may be useful to all AEDH without severe brain swelling, subdural hematoma and intracerebral hematoma.
Anesthesia, Local
;
Brain Edema
;
Craniotomy*
;
Hematoma*
;
Hematoma, Subdural
;
Humans
;
Postoperative Complications
;
Scalp
10.Retrieval of a dislodged and dismounted coronary stent; using a rendezvous and snare technique at the brachial artery level via femoral approach.
Min Woong JEONG ; Chang Bae SOHN ; Su Hong KIM ; Jong Ik PARK ; Se Ryeong PARK ; Jun Sik MIN
Yeungnam University Journal of Medicine 2016;33(2):138-141
Coronary stent dislodgement during percutaneous coronary intervention, which occurs when the stent is passed through tortuous and calcified lesions, is not a rare complication. Without proper treatment, such as fixing with another stent in the coronary artery or removing the undeployed stent from the coronary artery or systemic artery system, this complication can cause serious problems. We experienced the unusual situation of a dismounted and dislodged coronary stent, in which retrograde retrieval to the radial artery was impossible during transradial coronary intervention. We report on use of a rendezvous and snare technique at the brachial artery level via femoral puncture, which resulted in resolution without surgery.
Arteries
;
Brachial Artery*
;
Coronary Vessels
;
Endovascular Procedures
;
Percutaneous Coronary Intervention
;
Punctures
;
Radial Artery
;
SNARE Proteins*
;
Stents*