To know the effect of subconjunctival injection of liposome encapsulated cytarabine on proliferation of conjunctival fibroblasts, the conjunctiva was isolated at 180 degrees from the injection site 3 days after subconjunctival injection of the normal saline (control), cytarabine, liposome encapsulated cytarabine, and 1 day after injection of cytarabine, and then those were inoculated in the culture media of fibroblasts. In the case of 3 days after injection of cytarabine, there was 49% and 42% inhibition of proliferation of conjunctival fibroblasts compared with the control respectively. Therefore, the authors concluded that the liposome encapsulated cytarabine is effective on inhibition of proliferation of conjunctival fibroblasts and reduces the frequencies of subconjunctival injection compared with the cytarabine itself.
Conjunctiva ; Culture Media ; Cytarabine* ; Fibroblasts* ; Liposomes*

Polymyositis is uncommon, nonsuppurative Connective tissue disorder. We have experienced a case of polymyositis. Patient was a 20-y.ear old female in good healthy appearance with history of mild, progressive muscle weakness of lower extremities and inability to walk up and down of stairs in recent 3 weeks. Her symptoms were mainly subjective and individual muscle test revealed no abnormalities, but evidences of primary myopathy were easily obtained by muscle biopsy, electromyogram and several enzyme values. We are reporting a case of polymyositis with brief review of literature.
Biopsy ; Connective Tissue ; Female ; Humans ; Lower Extremity ; Muscle Weakness ; Muscular Diseases ; Polymyositis

Ambulatory BP monitoring was performed in a patients with pheochromocytoma before and after removal of the tumor. Before surgery, it did not show any significant diurnal variation. But, after surgery the diurnal variation was restored.
Blood Pressure Monitoring, Ambulatory* ; Blood Pressure* ; Humans ; Pheochromocytoma*

We are reporting a case of molluscum contagiosum in a 3-year-old boy who showed a good response to diphenylcyclopropenone (DPCP) immunotherapy. The lesions were multiple, 2 to 7mm in size, centrally umbilicated, normal skin-colored papules of 7 months' duration which were distributed on the penoscrotal area, extremities and trunk. In spite of several treatments using extraction and curettage, new lesions developed continuously. The patient was sensitized with 0.1ml of 1% DPCP solution in acetone on his right shoulder and there-after challenged with solution of varying concentrations (0.05 to 0.1%) on his left shoulder once or twice a week to maintain a mild eczema. Clinical improvement was noted 1 week after sensitization and almost all of the lesions cleared after 8 week's treatment.
Acetone ; Child, Preschool ; Curettage ; Eczema ; Extremities ; Humans ; Immunotherapy* ; Male ; Molluscum Contagiosum* ; Shoulder

Delayed and non-union of the femur shaft fractures in adult have been increased in spite of improvement of method of treatment. In geheral, the principal factors predisposing to delayed and non-union have been known as infection, disturbances of the blood supply, poor immobilization (inadequate rigid fixation), distraction of fracture site. 43 cases of the femur shaft fractures in adult over 18 years old examined at the department of orthopedic surgery, Korea General Hosipital, during the period of January 1973 to January 1982, were divided into two Groups; Group A was 31 cases, which had been taken solid bony union as control group and Group B was 12 cases, which had been developed delayed and non-union. Group A and B were analysed to find out other etiologic factors such as liver function which were suspicious to result in delayed or non-union of the fracture except above mentioned principal factors. The results were as follows, l. In delayed and non-union group (Group B), the interval of age was 20 to 40 years of age, open fracture was 33.4% comparing to control(6.5%), comminuted fracture was 83%, comparing to control (42%), the time interval to operation was delayed over 2 weeks(18%) comparing to control(8%g), and gap between fractured ends after internal fixation was more than 2mm in 33% comparing to control(absent), and liver function, especially, SGOT, and SGPT was bad in 46% comparing to control(13.4%). 2. All 3 cases ot infection in fracture site were in delayed and non-union group, tracture level, associated injury and postoperative immobilization were not concerned with delayed and non-union between two groups.
Adult ; Alanine Transaminase ; Aspartate Aminotransferases ; Femur ; Fractures, Comminuted ; Fractures, Open ; Humans ; Immobilization ; Korea ; Liver ; Methods ; Orthopedics

No abstract available.
Carcinoma, Squamous Cell* ; Colon* ; Colonic Polyps* ; Female* ; Humans ; Urethra*

PURPOSE: The purpose of this study was to explore internalized stigma of patients with schizophrenia and examine factors contributing to their internalized stigma. METHODS: Participants in this study were 173 patients schizophrenia living in Busan. Data were collected between January 2 to 16, 2012 using the Korean version of the Internalized Stigma of Mental Illness Scale (ISMI), and measurements of Self-esteem, Depression, Family and Social support, and Insight. Data were analyzed using the SPSS/WIN 18.0 program. RESULTS: The mean score for internalized stigma was 68.8+/-12.15. The significant factors influencing internalized stigma were depression, insight, admission status, mental health center services, number of admissions, self-esteem, and family support. These factors explained 40.8% of the variance. CONCLUSION: The results suggest that in development and practice of programs to decrease internalized stigma in patients with schizophrenia factors identified in this study as influencing internalized stigma should be considered.
Depression ; Humans ; Mental Health ; Schizophrenia

We report a case of atypical eruption due to chemotherapeutic agent in a 60-year-old man who presented with asymptomatic, erythematous, 0.5cm in diameter, confluent, and elevated papules and plaques confined to the face. The patient was previously diagnosed with small cell carcinoma of the lung with liver metastasis. Two months after the diagnosis, a first course of chemotherapy including etoposide was started. Five days after starting the chemotherapy, the patient developed a facial eruption. Histopathologic examination demonstrated increased epidermal mitotic figures, cells in metaphase arrest, basal cell layer hyperpigmentation, prominent dyskeratosis, and squamous atypia. The most distinctive histologic feature was the presence of starburst cells, which are markedly enlarged pale staining keratinocytes containing small basophilic fragments of nuclear debris haphazardly scattered throughout the cytoplasm in a starburst pattern.
Basophils ; Carcinoma, Small Cell ; Cytoplasm ; Diagnosis ; Drug Therapy ; Etoposide ; Humans ; Hyperpigmentation ; Keratinocytes ; Liver ; Lung ; Metaphase ; Middle Aged ; Neoplasm Metastasis

PURPOSE: The purpose of this study was to determine the factors that affect suicidal ideation in patients with chronic mental illnesses, such as schizophrenia, depressive disorder, and bipolar disorder. METHODS: The research participants were 160 patients with mental illnesses residing in B City and G Province. They responded to questionnaires about their suicidal ideation, self-esteem, depression, family support, social support, and internalized stigma of mental illness. The collected data were analyzed using t-test, ANOVA, Pearson correlation coefficients, and STEPWISE multiple regression with the SPSS/WIN 18.0 program. RESULTS: History of self-esteem, Depression, Social support, Psychiatric diagnosis of MDD and suicide attempt showed an explanatory power for 64% of suicidal ideation in patients with chronic mental illnesses. CONCLUSION: Specialized health and medical service personnel providing services to patients with chronic mental illnesses must determine the risk factors and protective factors for suicidal ideation associated with each illness, and establish a more individualized and systemized case management system based on customized approach.
Bipolar Disorder* ; Case Management ; Depression ; Depressive Disorder* ; Depressive Disorder, Major ; Humans ; Mental Disorders ; Risk Factors ; Schizophrenia* ; Suicidal Ideation* ; Suicide

PURPOSE: The purpose of this study is to investigate employer's attitude towards mentally disabled people. METHODS: The Lee (1996)'s questionnaire of community people's attitude on perception for mentally disabled people was used to collect data from 208 employers in Busan City. chi2-test and t-test were used to explore related factors of employer's attitude. RESULTS: Employers having experience of hiring physically or mentally disabled people showed higher CAMI scores (p=.002). Especially, employers having experience of hiring mentally disabled people showed higher scores in four components of authoritarianism, benevolence, social restrictiveness, and community mental health ideology than any other groups. In addition, we found differences in employers' attitude on authoritarianism and benevolence according to types of industries and the number of employees. CONCLUSION: We could suggest that employers experience of employing disabled and mentally disabled people could improve their positive attitude. Therefore, we call for various efforts and programs development to encourage employers to hire mentally disabled people.
Authoritarianism ; Beneficence ; Humans ; Mental Health ; Mentally Disabled Persons ; Surveys and Questionnaires ; Rehabilitation, Vocational