OBJECTIVE:To evaluate the cost-effectiveness of levofloxacin and sparfloxacin in the treatment of non?gonococcus urethritis(cervicitis)patients.METHODS:The clinical data of levofloxacin and sparfloxacin in the treatment of nongonococcus urethritis were collected with evidence-based medicine method and were evaluated with pharmacoeconomic cost-effectiveness analysis.RESULTS:The cure rates of two drugs were71.16%(62.00%,80.32%),81.69%(78.71%,85.21%)and cost-effectiveness ratios were2.29and2.71respectively.The?C/?E was5.57.CONCLUSION:The cost-ef?fectiveness ratio of levofloxacin was lower than that of sparfloxacin although the cure rate of sparfloxacin for nongonococcus urethritis was better.

0.05).The most common adverse reactions of imiquimod were erythema,erosion,itching,excoriation,scabbing and oedema,those of podophyllotoxin were burning sensation,inflammation,erosion,pain,itching and bleeding.The incidence of ADR of podophyllotoxin was higher.Cost-effectiveness analysis indicated that the C/E of imiquimod and podophyllotoxin was36.88and8.15respectively.CONCLUSION:Imiquimod and podophyllotoxin possessed similar curative effect on condylo?ma acuminatum,but the cost and C/E of podophyllotoxin were lower.At the same time,podophyllotoxin had more serious ad?verse reactions.

Objective To compare the clinical feature and cognitive function between patients with obsessive-compulsive disorder of different onset age and explore possible subtype.Methods 140 Patients with obsessive-compulsive disorder (OCD) were enrolled in test.All finished a series of tests including clinical feature,Trail-making test (TMT),Tower of Hanoi (TH) and Word fluency test (WFT).Patients were divided into two groups by onset age of 18.Results Compared with patients of onset age after18,patients of onset before18 were more with episode duration and more suicide attitude( x2 =4.214,x2 =11.542,P＜ 0.05 ).In TMT patients of onset before 18 had shorter time and little errors( (81.696 ±50.172)vs( 109.114 ±48.070),(1.169 ±2.983) vs ( 1.405 ± 2.020),P ＜ 0.05 ).Conclusion Obsessive-compulsive disorder with different onset age may be different type.

Animals ; Cattle ; Humans ; Infant ; Infant Formula ; Milk Hypersensitivity ; Milk Proteins ; adverse effects

Objective Investigate the compatible stabilities of Sodium Glucuronic Acid Injection and Ganlixin Injection.Methods The Sodium Glucuronic Acid Injection mixed with Ganlixin Injection,to study the content of Sodium Glucuronic Acid Injection and Ganlixin Injection in different time by uv spectrophotometry,Investigate the appearance of the mixed solution,detect PH values and Insoluble Particles.Results At experimental temperature(15℃),the mixed solution,PH values,Insoluble Particles and the relative percentage have no obvious change in 4 hours.Conclusions The Sodium Glucuronic Acid Injection mixed with Ganlixin Injection is stabilization,so Sodium Glucuronic Acid Injection can combined with Ganlixin Injection.

Aim To investigate the effects of curcumin on expression of HIF-1? in human hepatocellular carcinoma BEL-7402 cells.Methods Different concentrations of 0,2.5,5,10,15 and 20 ?mol?L~(-1) curcumin-treated human hepatocellular carcinoma BEL-7402 cells were cultured under hypoxia for 6 hours.The cell proliferation and cell viability were assayed by WST-8 and the trypan blue dye exclusion method.The expression level of HIF-1? in human hepatocellular carcinoma BEL-7402 cells was checked by RT-PCR and Western Blot;0,10 ?mol?L~(-1) curcumin,10 ?mol?L~(-1) MG-132,and 10 ?mol?L~(-1) curcumin +10 ?mol? L~(-1) MG-132-treated human hepatocellular carcinoma BEL-7402 cells were cultured under hypoxia for 6 hours.The protein expression level of HIF-1? protein in human hepatocellular carcinoma BEL-7402 cells was checked by Western Blot.Results ① No significant difference was found in the cell proliferation rate and cell viability between control and different concentrations of curcumin.② Curcumin can down-regulate the expression of HIF-1? protein with the increasing concentrations.③ the effect of curcumin on expression of HIF-1?mRNA had no significant difference between control and different concentrations.④ MG-132 can reverse the curcumin-mediated decrease of HIF-1? protein.Conclusion Inhibitory effect of curcumin on expression of HIF-1? in human hepatocellular carcinoma BEL-7402 cells was acted through posttranscriptional mechanisms and the proteasome pathway.

Objective To explore the clinical features,diagnosis and treatment of solid-pseudopapillary tumor(SPT)of pancreas.Methods The clinical data of 19 patients with SPT treated in 8 years were studied retrospectively,included 3 males and 16 females.Results The type of operation was decided by the size and location of tumor.Pancreatic leakage was a familiar complication,there were 9 cases.Patients were followed up from 3 to 70 months,and no recurrence or metastsis was found.Conclusion Pancreas SPT is a rare type neoplasm of pancreas.Pancreas SPT is affecting primarily young women,complete resection results in excellent prognosis.

The intestine microbiota and the host interacts with each other.Resently,the association and causality between gut microbiota and cardiovascular diseases have been well studied.Some underlying mechanisms,especially metabolic pathways are known, including the role of trimethylamine N-oxide in the pathogenesis of atherosclerotic heart disease and heart failure and that of short chain fatty acids and their receptors in blood pressure regulation.