BACKGROUND: In patients with systemic lupus erythematosus(SLE), LE-specific cutaneous lesions include malar rashes, widespread/morbilliform erythema, oral ulcer and bullous lesions. OBJECTIVE: Clinical observations were carried out to define cutaneous features of morbilliform erythema and to see possible relevancy of this erythema to disease activity of SLE. METHODS: Examinations were performed on 7 SLE patients with morbilliform erythema regarding the distribution and course of the cutaneous lesions; some SLE-activity related hematologic/immunologic data taken during/around the time of this skin disease were also assessed in each patient. RESULTS: In most of those patients with morbilliform erythema, which covered the trunk and extremities, the skin lesions lasted for about 2 weeks until their disappearance. At or around the time of suffering from this skin disease of acute eutaneous LE, activities of systemic disease were recognized as "in a state of flare-up or aggravation" with hypocomplementemia and high titers of anti-nDNA autoantibodies. CONCLUSION: As with malar rashes, morbilliform erythema of acute cutaneous LE seems to develop more frequently at the time of severe systemic involvement of immunopathological processes of SLE.
Autoantibodies ; Blister ; Erythema* ; Exanthema ; Extremities ; Humans ; Lupus Erythematosus, Systemic* ; Oral Ulcer ; Skin ; Skin Diseases

No abstract available.
Immunocompromised Host* ; Kluyvera* ; Sepsis*

No abstract available.
Bilirubin* ; Brain Stem* ; Humans ; Infant, Newborn* ; Kernicterus*

No abstract available.

No abstract available.

No abstract available.
Genes, myc* ; Neuroblastoma* ; Polymerase Chain Reaction*

PURPOSE: Seizures arising from the frontal area are the second most common type of partial seizure disorder. As many of them showes various clinical manifestations, they are often misdiagnosed in children. This studies was performed to correlate clinical characteristics of children with electroencephalographic abnormal findings in the frontal area. METHODS: The clinical manifestations were analysed in 81 children with seizures showing interictal paroxysmal activities on scalp electroencephalography at frontal lobe area. This clinical manifestation involves type of seizure, frequency and duration of seizure, mental retardation, speech and motor development as well as medication. RESULTS: The abnormal electrical activities of frontal lobe were classified to spike or sharp waves in 56 cases, spike and waves in 16 cases, slow waves in 9 cases. 34 children had generalized tonic clonic seizures, 19 had partial seizure disorders, 8 had absence seizures, and 6 had atonic seizures, 12 had generalized tonic seizures, 2 had myoclonic seizures. Accompanying developmental disorders were mental retardation in 20 cases, speech delay in 27 cases, motor delay in 11 cases. Polytherapy is more common in children with specific etiology and absence seizure. CONCLUSION: Epileptic children with frontal paroxysmal activities in their EEG clinically manifestes partial and generalized seizure, and speech delay is the most frequent in developmental delay. Patents with frontal lobe epilepsy manifest various unpredictable clinical features.
Child* ; Electroencephalography ; Epilepsies, Partial ; Epilepsy, Absence ; Epilepsy, Frontal Lobe ; Frontal Lobe ; Humans ; Intellectual Disability ; Language Development Disorders ; Scalp ; Seizures

We have found out the relationship of nanoemulsion containing nano vitamin C, E and propolis and gingival disease. We've confirmed effect of nanoemulsion through the experiment of in vivo and in vitro. We tested cell viability of gingival fibroblast cells by MTT assay and mRNA appearance of interleukin-1 beta, using mouse that was guided inflammation. Anti-microbacterial activity for Antibacterial effect's experiment was carried out by using S.aureus and E.coli. In addition, inflammation tissue has been observed with scanning electrical microscopy. In this study, expression of interleukin-1 beta was decreased after adding nanoemulsion containing nanovitamin C, E and propolis. We've also obtained good results from the test of Antibacterial effect against S.aureus and E.coli. Also, swelling of inflammation tissues observed by scanning electrical microscopy has gone down. In conclusion, we have gained confidence that nanoemulsion containing nano vitamin C, E and propolis has very high Antibacterial effect against bacteria in oral. And it made us guess that inflammation of gingival reduces after decreasing interleukin-1 beta. Thus, we expect that nanoemulsion containing nano vitamin C, E and propolis gives good effects to patient having gingival disease.
Animals ; Ascorbic Acid ; Bacteria ; Cell Survival ; Fibroblasts ; Gingival Diseases ; Humans ; Inflammation* ; Interleukin-1beta ; Mice ; Microscopy ; Propolis ; RNA, Messenger

We describe three cases of morphea which present lesions of the disease at the site of mechanical traumas. In these patients, local traumatization of cutaneous tissue appear to be the initiating event for the developrnent of new lesions (isomorphic phenomenon) associated with their possible morphea prone constitutions. The mechanism involving these local stimuli responsible for the excessive collagen production is lifficult to explain. Upon biologic stress or trauma, normal cutaneous physiology may cause loca production and release of inflammatory mediators/cytokines, such as transforrning growth factor-beta(the major connective tissue growth factor-inducer). Perhaps, possible dysregulation of collagen-growth or fibrosis- promoting cytokines causing some clonal overactivity of the fibroblast, or with other undefined mechanisms may cause excessive synthesis of collagen to the local effects of such triggering factors in susceptible/subclinical individuals. Although no definite environrriental/physical influences on the developrnent of morphea have been described, rnechanical trauma niay occasionally be regarded as a contributing factor as seen in these patients.
Collagen ; Connective Tissue ; Constitution and Bylaws ; Cytokines ; Fibroblasts ; Humans ; Physiology ; Scleroderma, Localized*

A new synthetic pyridone carboxylic antimicrobial agent, Enoxacin (B-Mark(TM)) was administered orally in 37 cases of genitourinary tract infection and following results were obtained. 1. Among 12 cases of acute simple cystitis, the cure rate was 91.7%. 2. Among 6 cases of chronic complicated urinary tract infections, the cure rate was 66.7 %. 3. Among 9 cases of gonorrheal urethritis, the cure rate was 88.9%. 4. Among 10 cases of nongonorrheal urethritis, the cure rate was 60%. There was no serious side effects but mild G-I symptoms such as nausea, indigestion and fatigability were found. The results suggest that Enoxacin (B-Mark(TM)) is a useful antibacterial agent in the treatment of urinary tract infections, especially in acute simple cystitis and gonorrheal urethritis.
Cystitis ; Dyspepsia ; Enoxacin* ; Nausea ; Urethritis ; Urinary Tract Infections* ; Urinary Tract*