BACKGROUND: In patients with systemic lupus erythematosus(SLE), LE-specific cutaneous lesions include malar rashes, widespread/morbilliform erythema, oral ulcer and bullous lesions. OBJECTIVE: Clinical observations were carried out to define cutaneous features of morbilliform erythema and to see possible relevancy of this erythema to disease activity of SLE. METHODS: Examinations were performed on 7 SLE patients with morbilliform erythema regarding the distribution and course of the cutaneous lesions; some SLE-activity related hematologic/immunologic data taken during/around the time of this skin disease were also assessed in each patient. RESULTS: In most of those patients with morbilliform erythema, which covered the trunk and extremities, the skin lesions lasted for about 2 weeks until their disappearance. At or around the time of suffering from this skin disease of acute eutaneous LE, activities of systemic disease were recognized as "in a state of flare-up or aggravation" with hypocomplementemia and high titers of anti-nDNA autoantibodies. CONCLUSION: As with malar rashes, morbilliform erythema of acute cutaneous LE seems to develop more frequently at the time of severe systemic involvement of immunopathological processes of SLE.
Autoantibodies ; Blister ; Erythema* ; Exanthema ; Extremities ; Humans ; Lupus Erythematosus, Systemic* ; Oral Ulcer ; Skin ; Skin Diseases

No abstract available.
Immunocompromised Host* ; Kluyvera* ; Sepsis*

No abstract available.
Bilirubin* ; Brain Stem* ; Humans ; Infant, Newborn* ; Kernicterus*

No abstract available.

No abstract available.

No abstract available.
Genes, myc* ; Neuroblastoma* ; Polymerase Chain Reaction*

PURPOSE: Seizures arising from the frontal area are the second most common type of partial seizure disorder. As many of them showes various clinical manifestations, they are often misdiagnosed in children. This studies was performed to correlate clinical characteristics of children with electroencephalographic abnormal findings in the frontal area. METHODS: The clinical manifestations were analysed in 81 children with seizures showing interictal paroxysmal activities on scalp electroencephalography at frontal lobe area. This clinical manifestation involves type of seizure, frequency and duration of seizure, mental retardation, speech and motor development as well as medication. RESULTS: The abnormal electrical activities of frontal lobe were classified to spike or sharp waves in 56 cases, spike and waves in 16 cases, slow waves in 9 cases. 34 children had generalized tonic clonic seizures, 19 had partial seizure disorders, 8 had absence seizures, and 6 had atonic seizures, 12 had generalized tonic seizures, 2 had myoclonic seizures. Accompanying developmental disorders were mental retardation in 20 cases, speech delay in 27 cases, motor delay in 11 cases. Polytherapy is more common in children with specific etiology and absence seizure. CONCLUSION: Epileptic children with frontal paroxysmal activities in their EEG clinically manifestes partial and generalized seizure, and speech delay is the most frequent in developmental delay. Patents with frontal lobe epilepsy manifest various unpredictable clinical features.
Child* ; Electroencephalography ; Epilepsies, Partial ; Epilepsy, Absence ; Epilepsy, Frontal Lobe ; Frontal Lobe ; Humans ; Intellectual Disability ; Language Development Disorders ; Scalp ; Seizures

A new synthetic pyridone carboxylic antimicrobial agent, Enoxacin (B-Mark(TM)) was administered orally in 37 cases of genitourinary tract infection and following results were obtained. 1. Among 12 cases of acute simple cystitis, the cure rate was 91.7%. 2. Among 6 cases of chronic complicated urinary tract infections, the cure rate was 66.7 %. 3. Among 9 cases of gonorrheal urethritis, the cure rate was 88.9%. 4. Among 10 cases of nongonorrheal urethritis, the cure rate was 60%. There was no serious side effects but mild G-I symptoms such as nausea, indigestion and fatigability were found. The results suggest that Enoxacin (B-Mark(TM)) is a useful antibacterial agent in the treatment of urinary tract infections, especially in acute simple cystitis and gonorrheal urethritis.
Cystitis ; Dyspepsia ; Enoxacin* ; Nausea ; Urethritis ; Urinary Tract Infections* ; Urinary Tract*

A 13-year-old male presented with a walnut-size tender swelling of the left supraclavicular area. The lesion developed 4 months after BCG vaccination in a left. upper arm location. The supraclavicular lesion gradually increased in size and became suppurative witii resultant sinus formation. Histopathological examination of the nodular lesion showei3 foci of epithelioid granulomas with caseation necrosis, and several Langhans' type giant cells. After a diagnosis of BCGitis was made, the patient was, treated with isoniazid an l rifampin for two months without much benefits. Surgical excision of the lesion were performed to expedite clinical regression. After six months of antituherculous chemctherapy, a clinical remission was evident. Scrofuloderma-like BCGitis as well as other cutaneous complications of BCG vaecination are not uncommon. Thus, the practicing dermatologist should be aware of these complications, for correct diagnosis and treatment.
Adolescent ; Arm ; Diagnosis ; Giant Cells ; Granuloma ; Humans ; Isoniazid ; Male ; Mycobacterium bovis ; Necrosis ; Rifampin ; Vaccination

We recently encountered a case of pemphigus vulgaris, which was localized within the oral mucosa and esophagus. The patient was a 62-year-old women, who had had a few recurrent erosions on the oral mucosa for 1 year. Newly developed erythematous erosions on the esophagus appeared 7 days pre previously. Histopathological findings showed suprabasal blisters in the epithelium of the buccal and esophageal mucosa. On direct immunofluorescence, intercellular IgG and C3 bindings were found in the epithelium of the buccal mucosa. Treatment with oral steroids resulted in a remission of the lesions and the other skin lesions were not found for a period of 6 months.
Blister ; Epithelium ; Esophagus* ; Female ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoglobulin G ; Middle Aged ; Mouth Mucosa* ; Mucous Membrane ; Pemphigus* ; Skin ; Steroids