No abstract available.
Animals ; Permeability* ; Rats* ; Urinary Bladder*

To determine the value of ultrasonography for the diagnosis of testicular rapture due to blunt trauma, we reviewed 69 patients of blunt scrotal trauma, which were evaluated by ultrasound before treatment. Thirty patients were managed conservatively, of which 3 cases were explored lately due to persistent pain or mass, and 39 explored immediately. Of the 30 patients treated conservatively the injury was resolved in 27. Surgical exploration of the 42 cases revealed testicular rupture in 29 and simple hematocele in 13. Analysis of the 29 cases with testicular rupture demonstrated that orchiectomy rates were 20% in early exploration and 53% in delayed exploration. in the 27 cases the testicular rupture was correctly diagnosed by ultrasonography, and there were 4 false-positive and 2 false-negative diagnoses of rupture. The specificity and sensitivity for the diagnosis of testicular rupture are 70% and 93%, and the positive and negative predictive values are 87% and 82%, respectively. Ultrasonography used in conjunction with a thorough physical examination is highly sensitive in identifying testicular rupture, and can provide objective information supporting the need for early surgical exploration in patients with blunt scrotal trauma.
Diagnosis ; Hematocele ; Humans ; Male ; Orchiectomy ; Physical Examination ; Rupture* ; Sensitivity and Specificity ; Ultrasonography*

Steatocystoma multiplex is a relatively rare condition characterized by multiple, small, yellowish, cystic nodules 2 to 4mm in diameter locatcd princioally on the upper arms and the thighs. This has a high familial tendency and probably has an autosomal dominant mode of transmission. These tumors of steatocystoma multiplex characteristically contain hair follicles and sebaceous glands, and are to be the dermoid cyst. There was a familial and congenital inferiority in the ectoderm in both patient and family, ie, ichthyosis, hypohidrosis, koilonychia, milia and comedones. A 26 year-old Korean soldier was seen in February of 1970. His condition started 10 years previously. The widespread cystic nodules were 0. 2 to 1 cm in size and yellowish in color, and located on chest, back, scrotum and behind both ear lobes. There was thickening and daky brownish discolorations of all finger and toe nails. His father and two brothers had similar disorders, HistoIogieally clusters of hairs, mainly of lanugo size but some of intermediate character, were found in the lumen.
Adult ; Arm ; Dermoid Cyst ; Ear ; Ectoderm ; Fathers ; Fingers ; Hair ; Hair Follicle ; Humans ; Hypohidrosis ; Ichthyosis ; Military Personnel ; Scrotum ; Sebaceous Glands ; Siblings ; Steatocystoma Multiplex ; Thigh ; Thorax ; Toes

PURPOSE: The goal of this study was to investigate the impact on quality of life of urinary incontinence and to examine its relationship with treatment need in community women according to the frequency of stress urinary incontinence(SUI) and SEAPI score. MATERIALS AND METHODS: In 554 of total 811 women, a questionnaire survey was conducted in a typical farming village of a southern region of Korea. The frequencies of SUI were divided into 5 groups(A, less than 12 times/year; B, less than 4 times/month; C, 1 time/week; D, more than 2 times/week; and E, more than 1 time/day) and the SEAPI score into 3 groups according to the sum of all categories(a, 0-5; b, 6-10; and c, 11-15). Each objective criterion was compared with the responders' quality of life indices, cognition indices about symptom and acception indices of treatment. RESULTS: Of the 554 participants, 274(49.5%) had experienced SUI at least once in the last year. In the study of influences on quality of life according to the frequency of SUI and SEAPI score, statistically significant correlations were noted from groups C and b about daily life and social life categories(p<0.05), but not in the sexual life category. Groups E and b had statistically significant correlation in the influences on cognition of symptom(p<0.05). Groups C and b had statistically significant correlation in the influences on the acceptance of treatment (p<0.05). CONCLUSIONS: In spite of its great effect on quality of life, SUI has hardly induced community women to accept the need for its treatment. These findings suggest that more medical education and information about SUI should be offered. These preliminary results may be used as quality of life indices, cognition indices about symptoms and acception indices in future SUI surveys.
Cognition ; Education, Medical ; Female ; Humans ; Korea ; Quality of Life* ; Surveys and Questionnaires ; Urinary Incontinence ; Urinary Incontinence, Stress*

Mumps orchitis represents the most common complication of mumps infections and occurs in 5 to 37% of the populations. The most important danger is the risk of testicular atrophy up to 50% of affected testis which results in sterility. Two patients with mumps orchitis received systemic treatment with Interferon-alpha2(INF-alpha2)(3x06IU per day) for 7 days. All acute symptoms and signs of mumps orchitis disappeared within 4-7 days of INF-alpha2 therapy. No incidence of testicular atrophy was observed at the 19 and 6 months follow-up, respectively. No significant adverse effects of drug were occurred during treatment. We recommend the immediate interferon therapy, as soon as mumps orchitis manifests, to relieve clinical manifestation and to prevent testicualr atrophy and resulting infertility.
Atrophy ; Follow-Up Studies ; Humans ; Incidence ; Infertility ; Interferons ; Male ; Mumps* ; Orchitis* ; Testis

We report a case of male infertility secondary to pituitary apoplexy, which occurred as a sequela of korean hemorrhagic fever. A 32 years old male patient with past history of korean hemorrhagic fever was studied because of infertility and erectile impotence. The size of his testicles were about 8ml in Rt. and Lt. Semen analysis, endocrinologic studies, and brain MRI demonstrated hypogonadotrophic hypogonadism due to panhypopituitarism. The patient was treated with HCG (2,000 IU) administered intramuscularly three times per week for 6 months. After the treatment, improvement of male secondary sex characteristics such as hair growth and testicle size was noted. Promotion of sexual potency and improvement of semen quality were also noted. Following the treatment, his wife conceived after 6 months.
Adult ; Brain ; Erectile Dysfunction ; Hair ; Hemorrhagic Fever with Renal Syndrome* ; Humans ; Hypogonadism ; Infertility ; Infertility, Male* ; Magnetic Resonance Imaging ; Male ; Male* ; Pituitary Apoplexy* ; Semen Analysis ; Sex Characteristics ; Spouses ; Testis

Loss of heterozygosity (LOH) is a genomic aberration. In some cases, LOH can be generated without changing the copy number, which is called copy-neutral LOH (CN-LOH). CN-LOH frequently occurs in various human diseases, including cancer. However, the biological and clinical implications of CN-LOH for human diseases have not been well studied. In this study, we compared the performance of CN-LOH determination using three commonly used tools. For an objective comparison, we analyzed CN-LOH profiles from single-nucleotide polymorphism array data from 10 colon adenocarcinoma patients, which were used as the reference for comparison with the CN-LOHs obtained through whole-exome sequencing (WES) data of the same patients using three different analysis tools (FACETS, Nexus, and Sequenza). The majority of the CN-LOHs identified from the WES data were consistent with the reference data. However, some of the CN-LOHs identified from the WES data were not consistent between the three tools, and the consistency with the reference CN-LOH profile was also different. The Jaccard index of the CN-LOHs using FACETS (0.84 ± 0.29; mean value, 0.73) was significantly higher than that of Nexus (0.55 ± 0.29; mean value, 0.50; p = 0.02) or Sequenza (0 ± 0.41; mean value, 0.34; p = 0.04). FACETS showed the highest area under the curve value. Taken together, of the three CN-LOH analysis tools, FACETS showed the best performance in identifying CN-LOHs from The Cancer Genome Atlas colon adenocarcinoma WES data. Our results will be helpful in exploring the biological or clinical implications of CN-LOH for human diseases.

A foreign body near the bladder is rare. Although foreign bodies in the bladder can be easily found and removed by endoscopic transurethral removal, extravesical foreign bodies may require the use of an open or laparoscopic procedure. Here, we report a case of a patient complaining of frequency and urgency in whom an extravesical sewing needle was successfully removed by a laparoscopic approach. A 4.5 cm rusty sewing needle was found between the bladder and the left external iliac vessels and was removed through a 5 mm trocar port by use of endo forceps with no complications.
Foreign Bodies ; Humans ; Laparoscopy ; Needles ; Surgical Instruments ; Urinary Bladder

PURPOSE: The authors evaluated the clinical results and prognosis after amputating the lower extremity due to diabetic foot. MATERIALS AND METHODS:From 1991 to 2003, the patients who had suffered amputation of his lower extremity due to diabetic foot ulcer were evaluated retrospectively. 79 patients were male and 6 patients were female. The author evaluated the patient who had the ipsilateral additional surgery, contralateral amputation, level of blood sugar, combined disease and mortality rate within 5 years from medical record. Statistical analysis was done by Chi-square test and Kaplan-Meier survival test. RESULTS:Mean age of patients who had first experienced amputation was 63.4 years old. The mean duration of diabetes until amputation was 14.5+/-7.5 years. Major amputations were 50 cases and minor amputations 35 cases. 20 patients (23.5%) were suffered ipsilateral secondary surgery including revised stump. Overall 5-year mortality rate was 18.8% (16 cases). Death rate within 1 year was 8.2% (7 cases), mortality rate within 3 years was 14.1% (12 cases). 5-year mortality rate after major amputation was 20% (10 cases) and after minor amputation was 17.1% (6 cases). It was statistically significant (p<0.05). Patient who underwent more than 2 combined vascular related disease had higher mortality rate than diabetic amputee without combined disease (p<0.05). CONCLUSION: Mortality rate after major amputation was significant higher than amputation after minor amputation in diabetic patients from our data.
Amputation ; Amputees ; Blood Glucose ; Diabetic Foot ; Female ; Humans ; Lower Extremity ; Male ; Medical Records ; Prognosis ; Retrospective Studies ; Ulcer

Leiomyosarcoma of the penis is an extremely rare disease. We experienced a patient with a leiomyosarcoma on the ventral preputial skin of penis in a 45-year old man. The patient was treated with local wide excision with chemotherapy. Herein, we report this case with the review of literature.
Drug Therapy ; Humans ; Leiomyosarcoma* ; Male ; Middle Aged ; Penis* ; Rare Diseases ; Skin