Hypertension is the most common cardiovascular risk factor,and the injury of vascular endothelial function plays an important role in the pathogenesis mechanisms of hypertension.This article is to make an overview of the pathogenesis mechanism,clinical measurement and strategy of prevention and cure of hypertension-related endothelial function injury.

BACKGROUND: Pulsed electromagnetic field attracts much attention due to its less trauma, infection, side effect, and simple application to promote bone fracture healing.OBJECTIVE: To review the effect of pulsed electromagnetic fields on bone fracture healing by mechanism, animal experiments, and clinical application so as to provide theoretical evidences for promoting bone fracture healing. METHODS: This study was retrieved by the first author with the key words of "PEMF and fracture" in both English (1989-2009)and Chinese (1981-2009) from Pubmed database (http://www.ncbi.nlm.gov/Pubmed) and Vip database (www.cqvip.com). Articles which were related with the effect of pulsed electromagnetic fields or electromagnetic field on bone fracture healing were included.The duplicated articles were excluded. The retrieval articles included reviews, animal experiments, and clinical experiments.Among 62 articles, 32 were in English and 30 in Chinese. Following the primary retrieval, 9 articles were excluded due to unrelated researching aim, 6 due to duplication, and 7 due to reviews. A total of 40 articles, 16 in Chinese and 24 in English, wereincluded in the final analysis, including animal and cytological experiments (n=31), and clinical studies (n=9).RESULTS AND CONCLUSION: Pulsed electromagnetic field characterized by security, environmental protection, non-trauma,non-infection, sample processing, wide applicability, and less complications for treating bone fracture healing. Clinical experiments and clinical application have proved that pulsed electromagnetic field was an effective method to promote bone fracture healing, characterizing by low frequency and intensity. The mechanism of pulsed electromagnetic field for promoting bone fracture healing involved in physics and medicine. With the research of electromagnetism, organic complexity, and ethics, the parameters of pulsed electromagnetic field need to be further studied.

Recently,with the development of the medical technique includes surgery,radiotherapy,chemotherapy and molecular targeted therapy,multi-subject combined modality therapy for esophageal carei noma has been become a tendency instead of surgery alone.Any single treatment is hard to improve the curative effect of treatment for esophageal carcinoma.Systemic individual comprehensive therapy for the different patients with esophageal carcinoma is likely to reduce recurrence rate,improve survival rates as well as to improve the quality of life.

Objective To investigate the value of DNA image cytometry in thediagnose of benign and malignant pleuroperitoneal fluids by comparing with the liquid-based cytological results. Methods There were 417 cases in-volved in this study. Pap stain for cytology analysis and feulgen stain for DNA image cytometry were used to identify benign and malignant pleuroperitoneal fluids respectively,then compared the results of the two methods. Results Clinically or pathologically,213 were classified as malignant and the other 204 as benign. The sensitivity, specifici-ty,accuracy, positive predictive value and negative predictivevalue of DNA image cytometry were 89. 7%,100%, 94. 7%,100%,and 90. 3%,respectively. However,the sensitivity,specificity,accuracy, positive predictive value and negative predictive value of liquid-based cytology were 63. 4%, 81. 9%, 72. 4%, 78. 5%, and 68. 2%, re-spectively. There were significant differences in thesensitivity, specificity,accuracy, positive predictive value and negative predictivevalue. Conclusion DNA image cytometry has great application value in the diagnosis of benign and malignant pleuroperitoneal fluids, and can increase the positive rate, reduce misdiagnosed rate with liquid-based cytology.

Small intestinal submucosa has been applied in a variety of areas of basic and clinical study with its Characteristics of anti-infective and Low immunogenicity and so on.However,it is common to find the shrinkage and other problems in some tissue repair,and affects the functional recovery of repaired tissue to a certain extent.Thus,it is still a question to be resolved that how to avoid the shrinkage and other adverse effects after tissue repair.This paper provides a reliable basis for further correct understanding of the SIS's capacity of tissue repair by reviewing and summarying its characteristics and present situation of tissue repair,especially put forwarding the shrinkage problem.

SUMMARY Lymphoma is a systemic disease. It is not uncommon to be found involved in digestive or central nervous system. However, lymphoma involved in these two systems at the same time is rare. The clinical feature of a case of lymphoma with gastrointestinal bleeding and limbs weakness was investigated and the literature was reviewed. The patient came to our hospital with melena and hematemesis. She was diagnosed as gastric ulcer by gastroscopy and biopsy showed lymphoma. Two days after she came to hospital, the patient presented with progressing limbs weakness. Magnetic resonance imaging (MRI) showed irregular abnormal signals in T2-T4 vertebra, which was enhanced obviously. A strip abnormal signal could be seen in spinal cord and involved in neighboring centrum and ribbing. The lesion extended to paravertebral tissue. The final diagnosis was lymphoma involved in stomach and spinal cord. Diseases presented with both upper digestive tract bleeding and symptoms of central nervous system were rare, including malignancies, virus infection and some therapy. Lymphoma was one of the causes. On the other hand, spinal cord ischemia might occur after gastrointestinal bleeding. Thus, doctors should examine the patients carefully to diagnose these diseases.

Objective To investigate the preventive effect of nabumetone on the damaged esophageal mucosa in the model of reflux esophagitis, and the effect of expression of cyclooxygenase-2(COX-2), proliferating cell nuclear antigen(PCNA), cyclin D_ 1 (CD_ 1 ) on the progress of reflux esophagitis. Methods A total of 100 SD rats were divided into three groups in random: group Y: operation + saline as positive controls(46); group R: operation + nabumetone(46); and group C: normal control(8). The lesions of esophageal mucosa were observed in the 5th, 17th, 28th , 40th week in groups Y and R and 40th week in group C, respectively. The change of COX-2, PCNA, and CD_ 1 by immunoperoxidase staining in the progress of reflux esophagitis(RE) and the effect of nabumetone were evaluated. Results The lesions of esophageal mucosa at different time and the incidence of Barrett's esophagus(BE) in group R were lower than those in group Y (P

Objective Sterol regulatory element-binding proteins(SREBPs) are a family of nuclear transcription factors that regulate lipid metabolism in eukaryotic cells.They are over expressedin many malignant tumors,and closely related to tumor initiation and progression.We briefly summarize the research advancement of SREBPs in gynecological tumors.

Objective To probe into the status quo of maltreatment tendency among family caregivers of elderly patients with chronic diseases and its influence factors.Methods Totally 402 family caregivers of the elderly patients with chronic diseases were selected and surveyed by using the Chinese version of caregiver elder abuse assessment scale and the results underwent statistical analysis.Results 63.70％ of family caregivers in elderly patients with chronic diseases had the elder abuse risk tendency and its influence factors were involved with both aspects of family caregivers and the care recipients,including the gender,cultural level and self-care ability of daily living in the elderly patients with chronic diseases and the age,cultural level,care period and living together with elderly in caregivers.Conclusion The elder abuse problem in the patients with chronic diseases should be paid more attention to,which needs the collaboration of multidisciplinary team,various effective ways should be adopted to relieve the family caregivers' pressure for reducing the occurrenc of elder abuse risk.

Objective To explore the diagnosis reliability of the 64-slice spiral CT to the patency of coronary arterial stents after PCI .Methods From September 2009 to December 2012 ,84 patients with 132 coronary artery stents accepted 64-slice spiral CT coronary artetry imaging and coronary angiography .The patency of the stents and the vascular were assessed compared with coro-nary angiography images ,and the diagnostic sensitivity ,specificity and accuracy were analyzed and compared .Results By calculat-ed the number of patients ,the stent occlusion sensitivity and accuracy of 64-slice spiral CT coronary artetry imaging were both 100% .The stent occlusion and stenosis (>50% ) sensitivity ,false negative and positive predictive value were 96 .7% ,3 .4% and 100% .64-slice spiral CT reconstruction imaging of the stent occlusion and stenosis (>50% ) compared with coronary angiography had no statistical difference(χ2 =0 .022 ,P=0 .883) .Conclusion Compared with coronary angiography ,64-slice spiral CT coronary artetry imaging has the higher accuracy and reliability .