Introduction: Our aim was to examine the changes in the self-rated frequency of activities among elderly residents living in communities during the self-restraint period associated with the Coronavirus Disease 2019 (COVID-19) pandemic.Methods: Regular outpatients aged 75 years or older who visited the hospital or clinic at the Center for Community Medicine in north-western Gifu prefecture between May 11 and May 22, 2020 were selected as participants. The frequency of outings, walks, outdoor exercise, indoor exercise, farm work, communication and interaction, such as at community salons, direct communication with friends and estranged family members, and remote communication by telephone and video calls was surveyed using a questionnaire method at four levels: "0 days", "1-2 days", "3-4 days", and "5 days to every day" per week in the two weeks prior to the visit and in the same period in the previous year.Results: In total, 292 people aged 75-95 years participated in the study. There was an increase in the number of respondents who reported a lower frequency of going out, walking, farming, outdoor exercise, home exercise, visiting community salons, and direct conversation than in the previous year. There was a significant difference between the two groups (P<0.05).Conclusion: In this study, the self-rated frequency of physical activity and social activity decreased among community-dwelling elderly due to the COVID-19 epidemic, suggesting a reduction in these activities.

Purpose: To investigate the clinical significance of adaptive radiotherapy (ART) in locally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT). Materials and Methods: Eligible patients were treated with concurrent chemoradiotherapy using IMRT. Planning computed tomography in ART was performed during radiotherapy, and replanning was performed. Since ART was started in May 2011 (ART group), patients who were treated without ART up to April 2011 (non-ART group) were used as the historical control. The Kaplan-Meier method was used to calculate overall survival (OS), locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and distant metastasis-free survival (DMFS). LRFS for the primary tumor (LRFS_P) and regional lymph node (LRFS_LN) were also studied for more detailed analysis. Statistical significance was evaluated using the log-rank test for survival. Results: The ART group tended to have higher radiation doses. The median follow-up period was 127 months (range, 10 to 211 months) in the non-ART group and 61.5 months (range, 5 to 129 months) in the ART group. Compared to the non-ART group, the ART group showed significantly higher 5-year PFS (53.8% vs. 81.3%, p = 0.015) and LRFS (61.2% vs. 85.3%, p = 0.024), but not OS (80.7% vs. 80.8%, p = 0.941) and DMFS (84.6% vs. 92.7%, p = 0.255). Five-year LRFS_P was higher in the ART group (61.3% vs. 90.6%, p = 0.005), but LRFS_LN did not show a significant difference (91.9% vs. 96.2%, p = 0.541). Conclusion Although there were differences in the patient backgrounds between the two groups, this study suggests the potential effectiveness of ART in improving locoregional control, especially in the primary tumor.