Objective To evaluate the effects of preventing and treating delayed gastric emptying (DGE)in the patients with pylorus preserving pancreaticoduodenostomy(PPPD).Methods The clinical data about PPPD from 1992～2000 were analyzed retrospectively.Results The incidence rate of DGE was 50%,among which gastrostomy was performed in 2/2 cases and not performed in four tenths.Comparing gastric decompression through noses with gastrostomy,the function of gastric wriggle recovered ahead of seven to fifteen days in the former group.Conclusion The incidence rate of DGE in the patients with PPPD is very high.Preventive jejunostomy should routinely be taken and the application of the thin silicon rubber tube through nose is very effective to gastric decompression,combining the traditional Chinese medicine with western medicine.

Objective To summarize the diagnosis and therapy of traumatic rupture of bladder.Methods Between January 1987 and December 2000,the diagnosis,therapy and effect was retrospectively analyzed on 47 patients with traumatic rupture of bladder.45 cases were finally diagnosed with bladder perfusion,2 were found in urethra reunion operation because of urethra disruption.47 cases were surgically treated with open repair,35 cases with bladder fistulization and 12 only with bladder catheterization.Result 2 of 47 cases died because of shock and serious combined injury.45 were have healed,and urination recovered after surgery.Conclusions Intravesical perfusion with water of bladder and abdominal puncture are simple and reliable method to diagnose rupture of bladder.Repairing of bladder is a important measure to therapy rupture of bladder.

Cell Line, Tumor ; Choriocarcinoma ; metabolism ; Chorionic Gonadotropin ; pharmacology ; Female ; Humans ; Tissue Inhibitor of Metalloproteinases ; metabolism

Objective To assess the value of MR susceptibility weighted imaging(SWI) in the diagnosis of cerebral developmental venous anomaly(DVA). Methods Twenty-four patients with DVA were examined with 3.0T MR scanner, the sequences included spin echo T_1 WI, the turbo spin echo T_2 WI and SWI. The MR imaging features of DVA on SWI and conventional MR imaging were compared. Results Of the 24 cases with DVA, the lesions located in the white matter of frontal lobe(11 lesions), white mater of pa-rietal lobes (6 lesions), temporal lobes (2 lesions) and cerebellar hemispheres (5 lesions) respectively. Only 11 lesions were detected by pre-contrast MRI, which demonstrated as linear flow void in 4 cases and as radiated high signal intensity on T_2 WI in 7 cases. On contrast-enhanced MR imaging, all the lesions showed typical "caput medusae"-like enhancement. On SWI, all the lesions showed typical "caput medusae"-like low signal intensity. Conclusion SWI is sensitive to small venous anomaly and it can be a substitutive modality for contrast-enhanced MR imaging in the diagnosis and follow-up of DVA.

OBJECTIVE:To compare the therapeutic effect,adversere reactions and cost-effectiveness between granisetron and ondansetron in preventing nausea and vomiting caused by cancer chemotherapy.METHODS:Using pharmacoeconomic co_st-effectiveness analysis,the relevant therapeutic indices were evaluated.RESULTS:The effective rates of granisetron in preventing nausea and vomiting were 83.6% and 86.8% with an average cost of 210.48 yuans in a therapeutic couse,the cost-ef_fective ratio being 251.77 and 242.37,and those of ondansetron were 72.9% and 83.7% with an average cost of 381.35 yuans,the cost-effective ratio being 523.11 and 456.62.CONCLUSION:Granisetron can effectively prevent nausea and vomiting caused by cancer chemotherapy,and its cost-effective ratio is superior to that of ondansetron.

Objective To evaluate the effects of preventing and treating delayed gastric emptying (DGE)in the patients with pylorus preserving pancreaticoduodenostomy(PPPD).Methods The clinical data about PPPD from 1992～2000 were analyzed retrospectively.Results The incidence rate of DGE was 50%,among which gastrostomy was performed in 2/2 cases and not performed in four tenths.Comparing gastric decompression through noses with gastrostomy,the function of gastric wriggle recovered ahead of seven to fifteen days in the former group.Conclusion The incidence rate of DGE in the patients with PPPD is very high.Preventive jejunostomy should routinely be taken and the application of the thin silicon rubber tube through nose is very effective to gastric decompression,combining the traditional Chinese medicine with western medicine.

Adult ; Athletes ; Electroencephalography ; Female ; Humans ; Male ; Sports ; physiology

OBJECTIVE:Study regarding Smad3/transforming growth factor-β1(TGF-β1)signal transduction in pathological scars mainly focus on in vitro cultured fibroblasts,however,the correlation study was rare on keloid.The aim of this study is to detect the expressions of Smad3 and TGF-β1,and investigate their relationship in pathogenesis and development of pathological scars METHODS:Experimental samples were obtained frOm the patients who underwent burn and plastic surgery at the Department of Burn and Plastic Surgery,Workers'Hospital of Tangshan,Hebei Medical University,from June 2004 to June 2008,including 48 patients with Keloid,aged 16-52 years,and 40 patients with hypertrophic scars aged 18-56 years.Normal skins from additional 40 cases were served as controls The expressions of Smad3 and TGF-β1 protein in keloid,hypertrophic scars and normal skin were examined by flow cytometry.RESULTS:The expression of Smad3 and TGF-β1 were obviously greater in the experimental group than that of the control group (P＜0.05),but the difference between keloid and hypertrophic scars had no significance(P＞0.06).There was a positive correlation between Smad3 and TGF-β1 in keloid and hypertrophic scars(r=0 489 2,P=0.000 4:r=0.471 0,P=0.002 2).No notable correlation was found between Smad3 and TGF-β1 in normal skins(P=0.471 4).CONCLUSION:The expressions of Smad3 and TGF-β1 are up-regulated and the synergism of Smad3 and TGF-β1 may promote the development in pathological scars.

Objective To study the biological effects of dose radiotherapy for primary liver cancer patients with stereotactic body portion.Methods 80 patients with primary liver cancer were selected.According to a random number table method, all patients were divided into observation group and control group,40 patients in each group.All patients were treated with stereotactic body radiotherapy treatment, the observation group was treated with high dose, while the control group received low-dose.The radiotherapy effects of different doses were analyzed and compared.Results After treatment, the effective rate of the observation group was 77.5%,which of the control group was 55.0%, ,the difference between the two groups was statistically significant (x2=4.528,P=0.033).After treatment for 6 months,1 year and 2 years, the survival rates of the observation group were 77.5%,75.0%,72.5%, which were significantly higher than 55.5%,52.5%,50.0% of the control group (P<0.05).The incidence rate of adverse reactions of the observation group was 42.5%, which was significantly lower than 72.5% of the control group (x2=7.365,P=0.006).Conclusion Stereotactic body radiotherapy treatment with different therapeutic dose has different treatment efficacy, high-dose SBRT treatment has significantly higher efficacy, survival rate and lower adverse reactions, which is worthy of clinical application.

AIM:To compare the therapeutic effect，adverse reactions and the costs between GM-CSF and G-CSF in treating leucopenia in chemotherapy of cancer.METHODS:Using pharmacoeconomic cost-effectiveness analysis，GM-CSF was compared with G-CSF in treatment of leucopenia in chemotherapy of cancer.RESULTS:The effective rate of GM-CSF was 80％ with an average cost of 1 008 yuan in a therapeutic course，the cost-effective ratio being12.6，and that of G-CSF was 85.7％ with an average cost of 2 304 yuan，the cost-effective ratio being 26.88.CONCLUSION:GM-CSF can effectively treat leucopenia in chemotherapy of cancer，and its cost-effective ratio ia superior to that of G-CSF.GM-CSF is worthy to be used clinically.