No abstract available.
Melanoma ; Nevus

No abstract available.
Osteoarthropathy, Primary Hypertrophic* ; Peptic Ulcer* ; Polyps* ; Stomach*

Intracranial meningioma is a common benign tumor. Although tumor mass might have been totally removed, aggravation of symptoms or recurrence of mass may sometimes be noticed. Histopathologic finding has been known as one of probable prognostic factors in meningiomas. In this study, correlation between DNA contents and histopathologic findings were evaluated to elucidate further such factors having role in the recurrence or prognosis in meningiomas. Seventy four cases of meningiomas were selected to review clinical prognosis and histopathologic findings. The speciemens were re-evaluated with flow cytometry to get DNA histogram. DNA fractions and proliferation index(PI) were calculated. The correlations were statistically analyzed with t-test and ANOVA test. Benign meningiomas were 53(71.6%), atypical 19(25.7%), and malignant 2(2.7%). PI of benign was 10.80+/-1.36 and that of atypical being 18.00+/-5.19. Diploid cases were 48 in number(64.9%) and aneuploid 26(35.1%). PI of diploid was 8.10+/-5.56 and that of aneuploid 24.06+/-18.51. DNA index was 1.00+/-0.00 in enign, 1.00+/-0.33 in atypical, and 1.50+/-0.71 in malignant. There was one case(2%) in benign, 2(11%) in atypical, and 2(100%) in malignant meningioma which showed recurrence(p=0.0002). In benign meningioma, 1 out of 4 subtotally removed cases recurred whereas atypical and malignant meningiomas recurred even in totally removed cases. In conclusion, histopathologically malignant meningiomas have not been always aneuploid. If total removal is done in benign tumor, long-term follow-up is not needed because of no recurrence and no aggravation of symptom. Atypical meningioma with aneuploid and high PI(above 24) should be followed in longer duration, and malignant meningioma should be closely observed due to their higher recurrence rate.
Aneuploidy ; Diploidy ; DNA* ; Flow Cytometry ; Follow-Up Studies ; Meningioma* ; Prognosis ; Recurrence ; Statistics as Topic

Intracranial meningioma is a common benign tumor. Although tumor mass might have been totally removed, aggravation of symptoms or recurrence of mass may sometimes be noticed. Histopathologic finding has been known as one of probable prognostic factors in meningiomas. In this study, correlation between DNA contents and histopathologic findings were evaluated to elucidate further such factors having role in the recurrence or prognosis in meningiomas. Seventy four cases of meningiomas were selected to review clinical prognosis and histopathologic findings. The speciemens were re-evaluated with flow cytometry to get DNA histogram. DNA fractions and proliferation index(PI) were calculated. The correlations were statistically analyzed with t-test and ANOVA test. Benign meningiomas were 53(71.6%), atypical 19(25.7%), and malignant 2(2.7%). PI of benign was 10.80+/-1.36 and that of atypical being 18.00+/-5.19. Diploid cases were 48 in number(64.9%) and aneuploid 26(35.1%). PI of diploid was 8.10+/-5.56 and that of aneuploid 24.06+/-18.51. DNA index was 1.00+/-0.00 in enign, 1.00+/-0.33 in atypical, and 1.50+/-0.71 in malignant. There was one case(2%) in benign, 2(11%) in atypical, and 2(100%) in malignant meningioma which showed recurrence(p=0.0002). In benign meningioma, 1 out of 4 subtotally removed cases recurred whereas atypical and malignant meningiomas recurred even in totally removed cases. In conclusion, histopathologically malignant meningiomas have not been always aneuploid. If total removal is done in benign tumor, long-term follow-up is not needed because of no recurrence and no aggravation of symptom. Atypical meningioma with aneuploid and high PI(above 24) should be followed in longer duration, and malignant meningioma should be closely observed due to their higher recurrence rate.
Aneuploidy ; Diploidy ; DNA* ; Flow Cytometry ; Follow-Up Studies ; Meningioma* ; Prognosis ; Recurrence ; Statistics as Topic

Neutrophilic dermatosis of the dorsal hands (NDDH) is a recently described skin disorder regarded as a localized variant of acute febrile neutrophilic dermatosis (Sweet syndrome). The lesions of NDDH are characterized by erythematous plaques, pustules, and hemorrhagic bullae on the dorsal surface of the hands. Herein, we report a case of NDDH in a 52-year-old man with concomitant involvement of the ankle. The patient presented with well-demarcated erythematous papules, patches, and plaques on the dorsum of the hands as well as erythematous papules on the left ankle for 3 days. The lesions responded rapidly to systemic corticosteroid therapy.
Animals ; Ankle ; Blister ; Hand ; Humans ; Middle Aged ; Neutrophils ; Skin ; Skin Diseases ; Sweet Syndrome

OBJECTIVES: Mental health and work efficiency are adversely affected by exposure to physical and chemical hazards in the workplace. This study is the first large scale evaluation of the relationship between physical and chemical hazard exposure in the workplace in relation to the mental health of Korean workers. METHODS: A national survey of a random sample of workers (n=10,043) was conducted between June and September 2006 in Korea. Physical and chemical hazards in the workplace were considered if exposure occurred over more than a quarter of the time spent at work. Mental health problems were defined as work-related depression, anxiety or insomnia. We analyzed whether physical and chemical hazards were independent risk factors for work-related mental health problems by multiple logistic regression analysis after adjusting for age, gender, employment type, education, occupation, duty schedule, work hours, smoking, and alcohol consumption. RESULTS: The mean age of surveyed workers was 42 years and 58% were male. A total of 7.8% of workers had work-related mental health problems. Exposure to high temperature, mist, fumes, dust, chemicals, and radiation were associated with an increased risk of work-related mental health problems. CONCLUSIONS: This study reaffirmed that physical and chemical hazard exposure in the workplace significantly elevates the risk of work-related mental health problems.
Anxiety ; Appointments and Schedules ; Depression ; Dust ; Employment ; Hot Temperature ; Humans ; Korea ; Logistic Models ; Male ; Mental Health ; Occupations ; Risk Factors ; Sleep Initiation and Maintenance Disorders ; Smoke ; Smoking ; Vibration

BACKGROUND: The presence of serum varicella zoster virus (VZV) immunoglobulin M and G (IgM and IgG) aid diagnosis of and confirmation of immunization against varicella and herpes zoster. However, the relationship between serum VZV IgM and IgG and the clinical characteristics of VZV infection remains unclear. OBJECTIVE: We evaluated quantitative changes in serum VZV IgM and IgG in accordance with the clinical features of varicella, herpes zoster, and disseminated herpes zoster compared with a normal control group. METHODS: A total of 922 patients were classified into 3 groups: varicella, herpes zoster, and disseminated herpes zoster. We assessed serum VZV IgM and IgG titers in association with age, severity of skin lesions, duration of skin lesions, immune status, and neurologic complications. RESULTS: In patients with varicella and herpes zoster, serum antibody titer varied significantly depending on age and the duration of skin lesions. A high serum VZV IgM titer was related to varicella or disseminated herpes zoster viremia. In herpes zoster, elevated antibody titers, especially VZV IgM, were associated with severe skin lesions and the presence of neurologic complications. CONCLUSION: Serologic data for varicella and herpes zoster varied according to clinical features. A high serum VZV IgM titer was associated with an unfavorable clinical course of herpes zoster.
Chickenpox* ; Diagnosis ; Herpes Zoster* ; Herpesvirus 3, Human* ; Humans ; Immunization ; Immunoglobulin G ; Immunoglobulin M* ; Immunoglobulins* ; Skin ; Viremia

Lichen planus is a chronic papulosquamous disease that affects the skin and mucous membranes. It is characterized by pruritic violaceous papules that are most commonly seen on the extremities of middle aged adults, but the elderly are rarely affected. Hypertrophic lichen planus usually occurs on the extremities and especially on the shins, and it tends to be the most pruritic variant. An 82-year-old female presented with severe pruritic multiple papules and plaques on the both the upper and lower extremities for 1 year. At first, the lesions began as small, polygonal papules that formed verrucous plaques over several months. Histopathologic examination showed marked hyperkeratosis, irregular acanthosis and wedge-shaped hypergranulosis. The vacuolar alteration and the lymphocytic inflammatory infiltrate were accentuated at the base of the rete ridge. From these findings, we diagnosed these lesions as hypertrophic lichen planus. The lesions were treated with topical steroid and intralesional injection of steroid, and they were slightly improved after 2 months of therapy.
Adult ; Aged ; Aged, 80 and over ; Extremities ; Female ; Humans ; Injections, Intralesional ; Lichen Planus ; Lichens ; Lower Extremity ; Middle Aged ; Mucous Membrane ; Skin

No abstract available.
Anetoderma* ; Granuloma Annulare* ; Humans ; Infant*

Vestibular papillomatosis is an uncommon benign condition that can occur on labia minora and is considered as a normal anatomical variant of the vulva, as the female equivalent of pearly penile papules in men. Because vestibular papillomatosis resemble condyloma, it can be misdiagnosed as condyloma acuminatum and can lead to unnecessary treatment. We herein report a case of a 27-year-old women with multiple skin-colored soft papules on labia minora. The lesion was distributed symmetrically on the inner of labia minora and showed a separate base of individual projection. To the best of our knowledge, this is a unique case reported in the Korean dermatological literature.
Female ; Humans ; Male ; Papilloma ; Vulva