1.Should Very Old Patients Be Admitted to the Intensive Care Units?.
Korean Journal of Critical Care Medicine 2017;32(4):376-377
No abstract available.
Critical Care*
;
Humans
;
Intensive Care Units*
2.Evaluation and Management of Antenatal HydronephrosisEvaluation and Management of Antenatal Hydronephrosis.
Childhood Kidney Diseases 2015;19(1):8-13
Antenatal hydronephrosis (ANH) is one of the most common abnormal findings detected on prenatal ultrasound (US), and it has been reported in 1-5% of all pregnancies. The likelihood of significant postnatal pathologic abnormality in the urinary tract correlates with the degree of anterior-posterior diameter (APD) according to the gestational age. Detection of urologic anomalies prenatally permits fetal interventions that avoid complications in rare cases of bladder outlet obstruction with oligohydramnios even though their final benefits still remain controversial. There is no clear consensus on the extent and mode of postnatal imaging after a diagnosis of ANH. US is the mainstay of the postnatal evaluation and helps guide further testing with voiding cystourethrography (VCUG) and diuretic renography. Although most algorithms continue to recommend generous VCUG for identification of lower urinary tract anomalies, VCUG may be safely reserved for high grade ANH cases or any grade of ANH with dilated distal ureter without increasing the risk of urinary tract infection (UTI). There are conflicting studies about efficacy of postnatal prophylactic antibiotics. It still seems reasonable to consider use of a prophylactic antibiotic to prevent infant UTIs in high-risk populations, such as females and uncircumcised males with high grades of hydronephrosis, hydroureteronephrosis, or vesicouretral reflux.
Anti-Bacterial Agents
;
Child
;
Consensus
;
Diagnosis
;
Diagnostic Imaging
;
Female
;
Gestational Age
;
Humans
;
Hydronephrosis*
;
Infant
;
Male
;
Oligohydramnios
;
Pregnancy
;
Prenatal Diagnosis
;
Radioisotope Renography
;
Ultrasonography
;
Ureter
;
Urinary Bladder Neck Obstruction
;
Urinary Tract
;
Urinary Tract Infections
3.Evaluation and Management of Antenatal HydronephrosisEvaluation and Management of Antenatal Hydronephrosis.
Childhood Kidney Diseases 2015;19(1):8-13
Antenatal hydronephrosis (ANH) is one of the most common abnormal findings detected on prenatal ultrasound (US), and it has been reported in 1-5% of all pregnancies. The likelihood of significant postnatal pathologic abnormality in the urinary tract correlates with the degree of anterior-posterior diameter (APD) according to the gestational age. Detection of urologic anomalies prenatally permits fetal interventions that avoid complications in rare cases of bladder outlet obstruction with oligohydramnios even though their final benefits still remain controversial. There is no clear consensus on the extent and mode of postnatal imaging after a diagnosis of ANH. US is the mainstay of the postnatal evaluation and helps guide further testing with voiding cystourethrography (VCUG) and diuretic renography. Although most algorithms continue to recommend generous VCUG for identification of lower urinary tract anomalies, VCUG may be safely reserved for high grade ANH cases or any grade of ANH with dilated distal ureter without increasing the risk of urinary tract infection (UTI). There are conflicting studies about efficacy of postnatal prophylactic antibiotics. It still seems reasonable to consider use of a prophylactic antibiotic to prevent infant UTIs in high-risk populations, such as females and uncircumcised males with high grades of hydronephrosis, hydroureteronephrosis, or vesicouretral reflux.
Anti-Bacterial Agents
;
Child
;
Consensus
;
Diagnosis
;
Diagnostic Imaging
;
Female
;
Gestational Age
;
Humans
;
Hydronephrosis*
;
Infant
;
Male
;
Oligohydramnios
;
Pregnancy
;
Prenatal Diagnosis
;
Radioisotope Renography
;
Ultrasonography
;
Ureter
;
Urinary Bladder Neck Obstruction
;
Urinary Tract
;
Urinary Tract Infections
4.Localized Pigmented Villonodular Synovitis Causing Anterior Knee Pain: A Case Report.
Dae Kyung BAE ; Oh Soo KWON ; Jae Ryong CHA ; Dong Jun SHIN ; Chan Jong JUNG
Journal of the Korean Knee Society 2001;13(2):240-244
No Abstract Available.
Knee*
;
Synovitis, Pigmented Villonodular*
5.Should Very Old Patients Be Admitted to the Intensive Care Units?
The Korean Journal of Critical Care Medicine 2017;32(4):376-377
No abstract available.
Critical Care
;
Humans
;
Intensive Care Units
6.A Renal Size Discrepancy among the Findings of Renal Sonogram in Children with Their First Episode of Pyelonephritis is One of the Useful Parameters to Predict the Presence of Cortical Defects on the Acute DMSA Renal Scan
Yoowon KWON ; Bo kyeong JIN ; Seonkyeong RHIE ; Jun Ho LEE
Childhood Kidney Diseases 2019;23(1):36-42
PURPOSE: We investigated whether a renal size discrepancy on a renal sonogram (US) in children with febrile urinary tract infection (UTI) was correlated with the presence of cortical defects on their dimercaptosuccinic acid (DMSA) renal scan. METHODS: We examined 911 children who were admitted consecutively to our hospital with their first episode of febrile UTI from March 2001 to September 2014. All enrolled children underwent a US and DMSA scan during admission. According to the US findings, including the renal size discrepancy, data were compared between children with positive and negative DMSA scan results. A positive DMSA scan result was defined as reduced or absent tracer localization and indistinct margins that did not deform the renal contour. RESULTS: Mean renal lengths of the right and left kidneys were larger in children with positive DMSA scan results than in children with negative DMSA scan results (63.2±11.3 mm vs. 58.4±7.8 mm, P<0.001; 64.9±11.2 mm vs. 59.9±7.9 mm, P<0.001; respectively). A significant difference was observed in both renal lengths between children with positive and negative DMSA scan results (4.6±3.8 mm vs. 3.3±2.6 mm, P<0.001). A multiple logistic regression analysis, revealed that a small kidney, cortical thinning, and a renal length discrepancy on US findings were significant factors for predicting the presence of cortical defects on an acute DMSA scan [P=0.028, 95% confidence interval (CI) 1.054–2.547; P=0.004, 95% CI 1.354–4.810; P<0.001, 95% CI 1.077–1.190, respectively]. CONCLUSION: In conclusion, a renal size discrepancy on US findings in children with their first episode of febrile UTI was a helpful tool for predicting the presence of cortical defects on an acute DMSA scan.
Child
;
Humans
;
Kidney
;
Logistic Models
;
Pyelonephritis
;
Succimer
;
Urinary Tract Infections
7.Effects of Mesenchymal Stem Cells Treatment on Radiation-Induced Proctitis in Rats
Won Hee KIM ; Jun Hwan YOO ; In Kyung YOO ; Chang Il KWON ; Sung Pyo HONG
Yonsei Medical Journal 2023;64(3):167-174
Purpose:
There are no effective treatment methods with which to control complications of radiation proctitis with fistula or recurrent bleeding following radiation treatment for prostate, cervical, or rectal cancer. Mesenchymal stem cells (MSCs) can induce immune modification, resulting in tissue repair and regeneration. Therefore, we used a rat model of radiation-induced proctitis and observed the effects of using human placenta-derived (PD) and adipose tissue-derived (AD) MSCs.
Materials and Methods:
Female Sprague Dawley rats were irradiated at the pelvic area with 25 Gy. We injected 1×10 6 cells of human PD-MSCs, human AD-MSCs, human foreskin fibroblasts, and control media into the rectal submucosa following irradiation. We sacrificed rats for pathologic evaluation.
Results:
Fibrosis on the rectum was reduced in both MSC groups, compared to the control group. Mucosal Ki-67 indices of both MSC injected groups were higher than those in the control group. Although caspase-3 positive cells in the mucosa gradually increased and decreased in the control group, those in both MSC injected groups increased rapidly and decreased thereafter.
Conclusion
We demonstrated the effects of regional MSC injection treatment for radiation-induced proctitis in rats. MSC injection reduced fibrosis and increased proliferation in rat mucosa. Human AD-MSCs and PD-MSCs had similar effectiveness.
8.Gender differences in characteristics of adolescents with suicide attempt at the emergency department
Young Ju AN ; So Hyun PAEK ; Ok Jun KIM ; Jin Ah KIM ; Jae Hyun KWON ; Min Jung KIM
Pediatric Emergency Medicine Journal 2020;7(2):120-126
Purpose:
This study was performed to investigate the gender differences in suicide attempts in adolescents.
Methods:
We reviewed the medical records of adolescents (≤ 18 years) who had visited a university hospital emergency department (ED) for suicide attempts from January 2018 through December 2019. General characteristics of the adolescents, details of the attempt, and outcomes were analyzed. The characteristics were age, gender, the Korean Triage and Acuity Scale, previous attempts, and psychiatric history. The details were initial Glasgow Coma Scale, attempt-arrival time, living alone, method, place, and motivation of the attempt, and concurrent use of alcohol. The outcomes included psychiatric consultation, ED length of stay, and ED outcomes.
Results:
A total of 86 adolescents were included. Their age ranged from 13 to 18 years, and girls accounted for 65.1%. The girls had more frequent psychiatric history than boys (66.1% vs. 30.0%; P = 0.001) without a significant difference in previous attempts (55.4% vs. 46.7%; P = 0.442). The most common methods of the attempt in the girls and boys were poisoning and sharp objects (53.3% [16 of the 30 boys] vs. 60.7% [34 of the 56 girls]; P = 0.002), respectively. No differences were found in the other details of the attempt and in the rate of psychiatric consultation. The girls had longer ED length of stay (247.0 minutes vs. 186.5; P = 0.033), a lower rate of discharge against medical advice, and higher rates of hospitalization (discharge against medical advice, 53.6% vs. 76.7%; non-psychiatric, 23.2% vs. 3.3%; psychiatric, 12.5% vs. 0%; P = 0.003).
Conclusion
Girls may make suicide attempts, usually by poisoning, and undergo relevant hospitalization, more often than boys. In contrast, boys usually use sharp objects, with a higher rate of discharge against medical advice and lower rates of the attempt and hospitalization.
9.Gender differences in characteristics of adolescents with suicide attempt at the emergency department
Young Ju AN ; So Hyun PAEK ; Ok Jun KIM ; Jin Ah KIM ; Jae Hyun KWON ; Min Jung KIM
Pediatric Emergency Medicine Journal 2020;7(2):120-126
Purpose:
This study was performed to investigate the gender differences in suicide attempts in adolescents.
Methods:
We reviewed the medical records of adolescents (≤ 18 years) who had visited a university hospital emergency department (ED) for suicide attempts from January 2018 through December 2019. General characteristics of the adolescents, details of the attempt, and outcomes were analyzed. The characteristics were age, gender, the Korean Triage and Acuity Scale, previous attempts, and psychiatric history. The details were initial Glasgow Coma Scale, attempt-arrival time, living alone, method, place, and motivation of the attempt, and concurrent use of alcohol. The outcomes included psychiatric consultation, ED length of stay, and ED outcomes.
Results:
A total of 86 adolescents were included. Their age ranged from 13 to 18 years, and girls accounted for 65.1%. The girls had more frequent psychiatric history than boys (66.1% vs. 30.0%; P = 0.001) without a significant difference in previous attempts (55.4% vs. 46.7%; P = 0.442). The most common methods of the attempt in the girls and boys were poisoning and sharp objects (53.3% [16 of the 30 boys] vs. 60.7% [34 of the 56 girls]; P = 0.002), respectively. No differences were found in the other details of the attempt and in the rate of psychiatric consultation. The girls had longer ED length of stay (247.0 minutes vs. 186.5; P = 0.033), a lower rate of discharge against medical advice, and higher rates of hospitalization (discharge against medical advice, 53.6% vs. 76.7%; non-psychiatric, 23.2% vs. 3.3%; psychiatric, 12.5% vs. 0%; P = 0.003).
Conclusion
Girls may make suicide attempts, usually by poisoning, and undergo relevant hospitalization, more often than boys. In contrast, boys usually use sharp objects, with a higher rate of discharge against medical advice and lower rates of the attempt and hospitalization.
10.DNA-mediated Immunization Methods with the HCMV gB for the Induction of Neutralizing Antibodies to HCMV in BALB/c Mice.
Sang Jun JEON ; Ye Jin KWON ; Eun Suk PARK ; Chung Gyu PARK ; Eung Soo HWANG ; Chang Yong CHA
Journal of Bacteriology and Virology 2001;31(4):353-360
No abstract available.
Animals
;
Antibodies, Neutralizing*
;
Immunization*
;
Mice*