Objectives: To evaluate the analgesic effect of electronic dental anesthesia(EDA).　Methods: Sixty patients with dental caries in need of cavity preparation and 15 patients with pulpitis in need of pulp treatment were anesthetized with EDA, another 60 patients with dental caries in need of cavity preparation and 15 patients with pulpitis in need of pulp treatment were anesthetized with traditional local anesthesia(LA).　 Results: For patients with dental caries in need of cavity preparation, the effective rates in EDA group and LA group were 93.33% and 98.33% respectively(P>0.05).For patients with pulpitis in need of pulp treatment ,the effective rates in EDA group and LA group were 26.7% and 93.33% respectively(P<0.01).　Conclusions: EDA can be an effective analgesic method for cavity preparation, but not for pulp treatment.

OBJECTIVE To explore the risk factors in elderly patients with ventilator-associated pneumonia(VAP) and to provide the corresponding clinical prevention strategies.METHODS The ages,underlying diseases,mechanical ventilation method,use of antibiotics,and pathogenic bacteria of the VAP patients were investigated and analyzed.RESULTS Totally 105 elderly patients with VAP had serious underlying diseases,and were treated with broad-spectrum antibiotics,tracheal intubation or trachea incision.Most pathogenic bacteria were multiresistant.CONCLUSIONS Prevention of VAP is the priority of treatment for elderly patients.In order to control the occurrence and spread of VAP,clinicians should shorten the time of ventilator treatment,pay more attention to sterilization and isolation,and strengthen the attendance of the patients.

[Summary] The general status of glycemic control and insulin initiation are not optimistic in Chinese patients with type 2 diabetes.Chinese patients experience pancreatic β-cell dysfunction and reduction of early phase insulin spike earlier and more severely compared to Caucasians.These can cause more significant postprandial hyperglycaemia which is further deteriorated by traditional carbohydrate-rich Chinese diet.Therefore,premixed insulin may be a more appropriate option of insulin initiation therapy for Chinese patients with type 2 diabetes mellitus.

[ Objective] To observe the effect of removing phlegm,softening and removing blood stasis on pulmonary morphology and hydoxyprolin of pulmonary fibrosis rats. [Methods]The experimental pulmonary fibrosis models were produced by injecting BLMA5.All animals were randomly divided into 5 groups which were control group, model group, Chinese herb high-dose group, Chinese herb low-dose group and prednisone group respectively, the drugs were given daily starting from the second day and the rats were killed on the 7th and 28th day. The shape of rats’ lung tissues was observed, the levels of hydroxyproline in lung tissues were measured. [Results] In model group, alveolitis increases(much inflammatory cell infiltration), pulmonary interstitial fibroblast increases. There is less pulmonary tissue inflammatory cell infiltration in drug-given groups than that in model group and so is fibroblast. Compared with the model group, the content of HYP of pulmonary tissues of the drug-given groups is remarkably decreased. [Conclusion] The Chinese herb of removing phlegm, softening and removing blood stasis can effectively inhibit the formation of pulmonary fibrosis caused by BLMA5.

Objective To evaluate the clinical effectiveness of heat-sensitive moxibustion for knee osteoarthritis ( KOA) by systematic evaluation and Meta analysis methods. Methods Electronic information retrieval combined manual retrieval methods were used for collecting clinical randomized control trial of heat-sensitive moxibustion for KOA. The systematic evaluation was conducted by two individual researcher following the principles of Cochrane Review Handbook 5.1, and RevMan5.0 software was applied for the statistical analysis. Results Fifteen randomized controlled trials (RCT) were enrolled into the analysis, which involved 1228 cases. The results of systematic evaluation showed that the quality of most of the enrolled RCT were not so high. The results of Meta analysis were as follows: ( 1) Between heat-sensitive moxibustion and traditional moxibustion, the weighted mean difference (WMD) and 95%confidence index (CI) were-1.76, [-2.33, -1.18] for visual analog scale ( VAS) scores ( P<0.001) , were -2.36, [-3.42, -1.30] for the scores of guiding principle of clinical research on new drugs ( GPCRND) for KOA ( GPCRND-KOA) ( P<0.001) , and were 13.61, [7.60, -19.61]for Lysholm knee joint function scores (P<0.001), respectively; (2) Between heat-sensitive moxibustion and acupuncture, WMD and 95%CI were 6.19, [ 0.01, 11.37] for Lysholm scores ( P<0.05);(3) Between heat-sensitive moxibustion and warm-needling acupuncture, WMD and 95%CI were -10.14, [-17.47, -2.81] for the Western Ontario and McMaster Universities ( WOMAC) osteoarthritis index scores ( P<0.05). Conclusion It is indicated that heat-sensitive moxibustion shows certain therapeutic effect for knee osteoarthritis, better than traditional moxibustion.

I have used plastic-embedded, surgically resected specimens to teach surgery. These specimens were obtained from more than 100 cases of important surgical diseases, such as gastric cancer, goiter, and inflammatory diseases. They are more easily carried than are formalin-preserved specimens. After I teach my students each disease, I show the corresponding specimen, explain the pathologic changes, and discuss the surgical procedure with which they were obtained. I then let the students handle and examine the specimens. Observation of actual specimens will help students clearly understand diseases and give stronger impressions than can words, illustrations, or photographs.

BACKGROUND: Clinical study of insomnia is performed by monitoring the alpha wave of the brain signals with the polysomnography (PSG). PSG has two deficiencies in recording electroencephalogram (EEG): ①The testee is wrapped by long electrode wires so that they cannot sleep normally. As a result, the testee's mental and physical status is affected and the results are inaccurate. ②As the alpha wave consists of very weak biomedical signals, it is easily affected by the alternating current (AC) interference, so that the analytical software cannot identify the desired signals. For these reasons, a monitoring system that overcomes such deficiencies is needed. OBJECTIVE: To design a wireless EEG sensors system for detecting brain signals. It can obtain the brain signals in an accurate and non-disturbed way without affecting the testee's mental and physical status. DESIGN: The actual application circuit was implemented after analyzing and building the circuit model. SETTING: The 305 Hospital of Chinese PLA.MATERIALS: The clinical experimental environment was provided by the 305 Hospital of Chinese PLA. The PSG made by Beijing Rising Sun Science-Tech Co., Ltd. was served as experimental instrument for comparison test and analytical software was designed by MATLAB.METHODS: Theoretical analysis was performed at the 305 Hospital of Chinese PLA in 2005 to create the anti-interference model and the wireless EEG sensors system model. In 2006, the circuit model helped us realize the small-sized wireless brain wave sensor that could suppress the interference effectively. The sensor was put into practical use at the 305 Hospital of Chinese PLA from February to August 2006. The experiment was approved by the hospital ethics committee. The volunteer testees were those who worked in the hospital and they had full knowledge of the objective, process and results of the experiment. Besides, those signals were compared with what the PSG recorded. MAIN OUTCOME MEASURES: Frequency spectrum of signals obtained in interference environment. RESULTS: For the brain signals that were captured by the wireless EGG sensors in the presence of interference, the power spectrum peak value was 6 926.043 within the alpha wave ranged at 8-12 Hz. For the AC interference, the power spectrum peak value was 0.356 at 50 Hz. Meanwhile, for the brain signals that were captured by the PSG, the power spectrum peak value was 1112.3 within the alpha wave ranged at 8-12 Hz; for the AC interference, the power spectrum peak value was 85 440 at 50 Hz.CONCLUSION: The system can obtain satisfying brain alpha wave signals and can suppress AC interference effectively.

Platelet-derived growth factor(PDGF), as an important cytokine, can induce mesangial cell proliferation and accumulate extracellular matrix. The proliferation of the mesangial cells correlate with the cell cycle regulation. The different isoform of PDGF works on mesangial cells to produce different effects. This review summarizes the relevant mechanism about PDGF inducing proliferation of mesangial cells.

There is a pressing need for new antibacterial agents due to the development of drug-resistant pathogens. Unfortunately drug development is a difficult and complicated process. The traditional approach in searching for a right dose is quite empirical, both costly and time-consuming. To enhance the ability to predict the likelihood of success for lead compound selection, in vitro pharmacodynamic and in vivo animal infection models are now extensively used. The value of these pre-clinical experiments, combined with mathematical modeling, helps to identify a pharmacokinetic (PK)-pharmacodynamic (PD) exposure measure which best predicts the therapeutic efficacy, and to quantify the magnitude of this index required for in vivo efficacy. PK-PD target attainment analyses using Monte Carlo simulation to integrate interpatient variability in drug exposure (PK), drug potency (MIC), and in vivo exposure targets that are predictive of positive therapeutic outcomes are influencing antibacterial drug development for proof of concept, for dose and dosing interval selection, for determining susceptibility breakpoints, and for evaluating the clinical meaning of antibacterial resistance. In this article, the key concepts of antibacterial PK-PD and model based antibacterial drug development strategy and process are critically reviewed.