Background: White matter hyperintensity (WMH) is a risk factor for dementia and ischemic stroke. The atherogenic index of plasma (AIP) is a simple and cost-effective marker for the prediction of various vascular diseases. In this study, we evaluated the relationship between AIP and WMH in adults without cerebrovascular accidents. Methods: We analyzed the data of 281 adults, aged ≥26 years, who underwent brain magnetic resonance imaging (MRI) at the health promotion center of an education hospital between January 2014 and December 2018. Participants were divided into three categories according to tertiles of the AIP scores (T1: <0.20; T2: 0.20–0.48; and T3: >0.48). WMH was defined as a modified Fazekas scale score of 1–3 on brain MRI. A cubic spline curve was used to determine the linearity of the relationship between AIP and WMH. Multiple logistic regression analysis was used to evaluate the relationship between the AIP and WMH. Results: The prevalence of WMH was 45.7% in T1, 57.0% in T2, and 66.0% in T3 (T3 vs. T1, P for post-hoc analysis=0.005). The increased odds of WMH were associated with increased AIP. The odds ratio (OR) with a 95% confidence interval (CI) for WMH of T2 and T3 compared with T1 were 1.57 (0.88–2.80) and 2.30 (1.28–4.14), respectively. After adjusting for confounding variables, the OR with a 95% CI for WMH in the T2 and T3 groups vs. the referent T1 were 1.55 (0.76–3.13) and 2.27 (1.06–4.84), respectively. Conclusion AIP is independently and positively associated with WMH in a healthy population.

The present study was performed to evaluate histomorphological difference in various surface-treated implants in beagle. Implants(Implantium(R), Dentium Co. Korea) with pure titanium machined surface, acid treated surface, and Al2O3(50~100micrometer)blasted with acid treated surface were used in this study. All mandibular premolars of 1.5~2 year old male beagle dogs were extracted. At 3 months after extraction, the implants(phi 4mm, l6mm) were installed. The beagle were sacrificed at 1, 3 months after installation and then tissues including implants were prepared for non-decalcified specimens. These specimens were analyzed comparatively under light microscope. The results of this study were as follow 1. Higher rate of osseointegration were showed in the Al2O3(50~100micrometer)blasted with acid-treated surface. 2. Increased osseointegration were showed in the Al2O3(50~100micrometer)blasted with acidtreated surface with time. 3. Higher maturation of integration were showed in the Al2O3(50~100micrometer)blasted with acid-treated surface. In conclusion, surface treatment of Al2O3blasted with acid might be considered to shorten healing time and improve success rate as increasing contact of implant and bone.
Animals ; Bicuspid ; Dogs ; Humans ; Male ; Osseointegration* ; Titanium

No abstract available.
Humans ; Microsporum* ; Siblings* ; Tinea Capitis* ; Tinea*

Ten eels (Anguilla japonica) from a fish farm in Korea were examined and diagnosed with a Heterosporis infection. The gross lesions on the trunk were uneven and the concave parts were pasty. Histopathologically, lyses of the trunk muscles, degenerative muscle fibers and the scattered spores were observed. The sporophorocyst (SPC) contained several spores with a variety of shapes. Some SPC were disrupted and the spores in the SPC were scattered in the muscle tissues. Macrophages existed near the scattered spores. Electron microscopy revealed special structures such as sporophorocyst containing various developmental parasitic stages such as meronts, sporonts, sporophorous vesicles and spores.
*Anguilla ; Animals ; Aquaculture ; Fish Diseases/*parasitology/pathology ; Histocytochemistry/veterinary ; Korea ; Microscopy, Electron, Scanning Transmission/veterinary ; Microsporidia/*growth & development/ultrastructure ; Microsporidiosis/parasitology/pathology/*veterinary ; Muscular Diseases/parasitology/pathology/*veterinary

A 67-year-old male patient was admitted with an abrupt sudden cardiac death. He represented with an extreme electrical storm of 30 times of ventricular fibrillation (VF) episodes on one day. External shocks were performed to terminate VF. Transient J-wave in the inferior-lateral leads and Brugada electrocardiography pattern on the right precordial leads appeared during the electrical storm. And J-wave disappeared after the termination of electrical storm. We report a case of the appearance of J-wave during electrical storm in a patient with Brugada syndrome.
Brugada Syndrome ; Death, Sudden, Cardiac ; Electrocardiography ; Humans ; Male ; Shock ; Ventricular Fibrillation

BACKGROUND: Epidermal cysts are the most common type of epithelial cysts of the skin. There have been a few studies to determine the clinical and histopathological characteristics of epidermal cysts. OBJECTIVE: The purpose of this study was to evaluate the clinicopathological characteristics of 243 cases of epidermal cysts in the province of Chungcheongnam-do. METHODS: We retrospectively evaluated the clinical and histopathological features of 243 cases of epidermal cysts at Soonchunhyang University Hospital in Cheonan from January 1998 to December 2008. RESULTS: The ratio of male to female patients was 1.7:1. The age distribution of subjects at the first visit ranged from 11 months to 83 years. The most common site of occurrence was the face. The most common histopathological change of the cystic wall was atrophy. Cystic contents such as calcifications, parakeratotic cells, red blood cells as well as keratinous material were observed. We found stromal changes such as foreign body reactions, fibrosis and granulation tissue. Forty-seven cases were clinically misdiagnosed as other diseases, but subsequent histopathological findings demonstrated the presence of epidermal cysts. No particular relationship was found among duration, size, atrophy of the cyst wall and calcification of keratin material. CONCLUSION: We reaffirmed contiguity with previous reports. In addition, we found some cases could have been clinically misdiagnosed as other diseases. In addition, there was a poor relationship between the duration of the lesion and other variables such as the size of the lesion, the degree of atrophy of the cyst wall and calcification of keratin material.
Age Distribution ; Atrophy ; Epidermal Cyst ; Erythrocytes ; Female ; Fibrosis ; Foreign Bodies ; Granulation Tissue ; Humans ; Keratins ; Male ; Retrospective Studies ; Skin

PURPOSE: There is no effective treatment for patients with advanced gastric cancer having failed to respond to first line chemotherapy. The aim of this study was to evaluate the therapeutic activity, and safety, of a FEP regimen in patients with a recurrence of, or metastatic, gastric cancer that had been unresponsive to primary chemotherapy. MATERIALS AND METHODS: Recurred or metastatic gastric cancer patients that did not respond to a 5-fluorouracil based regimen were entered into this trial. The patients were treated with FEP (5-FU, etoposide and cisplatin) as salvage chemotherapy. The treatment regimen was 5-FU (900 mg/m2/day) by continuous infusion for 3 days, etoposide (90 mg/m2/day) on days 1, 2 and 3, and cisplatin (60 mg/m2/day) on day 2. This treatment was repeated every 3 weeks. RESULTS: Between December 1997 and October 2001, 28 patients were enrolled to the study. The response rate was 32.1% (95% CI 15.5~57.8%). The median times to progression and survival duration were 23~33 weeks, respectively. Among a total of 187 cycles of chemotherapy, the grade 3 and 4 hematological toxicities were leukopenia (6.4%), thrombocytopenia (1.6%), and grade 3 non-hematological side effects of nausea/vomiting (17.9%). CONCLUSION: FEP combination chemotherapy seems to be an effective treatment regimen for gastric cancer as salvage chemotherapy. To confirm these results, large scale of clinical trials will be required.
Cisplatin ; Drug Therapy ; Drug Therapy, Combination* ; Etoposide* ; Fluorouracil ; Humans ; Leukopenia ; Polytetrafluoroethylene* ; Recurrence ; Salvage Therapy ; Stomach Neoplasms* ; Thrombocytopenia