1.Charles Bonnet Syndrome Following Trans-Sphenoidal Adenomectomy without Optic Nerve Atrophy.
Jang Ho PARK ; Joon Ho AHN ; Jun Bum PARK ; Soohyun JOE
Psychiatry Investigation 2016;13(5):577-579
Charles Bonnet syndrome (CBS) can develop after trans-sphenoidal adenomectomy (TSA); however, the neural mechanisms remain unknown. Sensory deprivation and releasing phenomenon are both hypothetical explanations for this condition; however, there is no definite evidence that strongly supports either supposition. We report the first case of CBS after TSA without optic nerve atrophy. Postoperatively, the patient's vision seemed to be relatively well preserved, apart from the left-side hemianopsia in the right eye. Distinctive visual hallucinations only appeared when his eyes were closed, and these responded to quetiapine in a dose-dependent manner. Dose dependent change in colors and formation of hallucination was reported. Two weeks after quetiapine initiation, the patient's CBS was completely resolved. This unique case suggests that blocking sensory input from the periphery is more critical than neural damage of the bottom-up connection to the visual association cortex. In addition, quetiapine should be considered as a specific treatment for CBS.
Atrophy*
;
Hallucinations
;
Hemianopsia
;
Optic Nerve*
;
Quetiapine Fumarate
;
Sensory Deprivation
2.Effect of Udenafil on Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia in Rat Carotid Artery Injury Model.
Jun Ho JOE ; Kwang Suk LIM ; Ji Yong JIN ; Kyung Soo KIM
Korean Circulation Journal 2008;38(6):320-324
BACKGROUND AND OBJECTIVES: Neointimal hyperplasia, which was caused by smooth muscle cell proliferation, was noted to occur after performing percutaneous coronary intervention. Phosphodiesterase type 5 (PDE5) inhibitor has been shown to inhibit smooth muscle cell proliferation. Udenafil is one of the PDE5 inhibitors, and it is also expected to inhibit smooth muscle cell proliferation and reduce neointimal hyperplasia. We investigated the effect of udenafil on the smooth muscle cell proliferation and neointimal hyperplasia that occurs after balloon injury in the carotid arteries of rats. MATERIALS AND METHODS: Smooth muscle cells were treated with 1 mM, 100 micrometer, 10 micrometer, 1 micrometer and 100 nM concentrations of udenafil. The viability of the smooth muscle cells was evaluated by MTT assay. The carotid arteries of rats were injured with a balloon catheter. Udenafil (100 micrometer, 10 micrometer and 1 micrometer) was applied on the carotid artery adventitia after balloon injury. At 21 days after treatment, the carotid arteries were harvested and stained with H & E. The neointima and media area were measured with a computerized image analysis program. RESULTS: In the in vitro experiment, treatment with 1 mM udenafil reduced smooth muscle cell viability by 68.8+/-4.42% compared to the control group. In the balloon injured rat carotid artery, treatment with 100 micrometer udenafil reduced the neointima area by 71.8% compared to the control group. CONCLUSION: Udenafil administration effectively inhibited smooth muscle cell proliferation and it reduced neointimal hyperplasia in the balloon-injured rat carotid artery.
Adventitia
;
Animals
;
Carotid Arteries
;
Carotid Artery Injuries
;
Catheters
;
Cell Proliferation
;
Hyperplasia
;
Muscle, Smooth, Vascular
;
Myocytes, Smooth Muscle
;
Neointima
;
Percutaneous Coronary Intervention
;
Phosphodiesterase 5 Inhibitors
;
Pyrimidines
;
Rats
;
Sulfonamides
3.A Case of Cutaneous and Gastric Cavernous Hemangiomas.
Jae Young KIM ; Ho Jin SONG ; Chang Wook KIM ; Don Hyon JOE ; Jun Ho WANG ; Sang Woo KIM ; Young Sang YAN ; Sok Won HAN ; In Sik CHUNG ; Doo Ho PARK
Korean Journal of Gastrointestinal Endoscopy 2000;20(2):127-131
A hemangioma is a common soft tissue tumor, usually affecting the cutaneous regions of the head and neck in infancy and childhood. A hemangioma in the gastrointestinal tract is rare occurrence which is usually found in the submucosa of the small and large intestine, but rarely in the stomach. Infrequently, multiple cavernous hemangiomas have been reported on skin and in the intestines. A 23-year-old man was admitted with hematemesis. An upper endoscopy revealed a purple colored sessile lesion at the posterior wall side of the fundus which had surface erosion and erythema. This lesion was easy to bleed when the patient retched. Another sessile lesion was detected at the greater curvature side of the upper body. The patient had two intradermal soft masses at the back and left forearm. An X-ray revealed a phebolith that suggested a cavernous hemangioma. An abdomen CT and angiography revealed that these lesions were highly suggestive of hemangioma. Gastric wedge resection was performed and the histological diagnosis was gastric cavernous hemangiomas.
Abdomen
;
Angiography
;
Diagnosis
;
Endoscopy
;
Erythema
;
Forearm
;
Gastrointestinal Tract
;
Head
;
Hemangioma
;
Hemangioma, Cavernous*
;
Hematemesis
;
Humans
;
Intestine, Large
;
Intestines
;
Neck
;
Skin
;
Stomach
;
Young Adult
4.Operation Status and Improvement Plan of Continuing Hospitalization Judgement System in Mental Health Review Board
Sun Joo PARK ; Yoon Young NAM ; Tae Yeon HWANG ; Keun Ho JOE ; Jin Yong JUN ; Eun Jin KIM ; Chul Eung KIM
Health Policy and Management 2017;27(4):346-357
BACKGROUND: The recent revision of South Korea's Mental Health Law emphasizes the role of the Mental Health Review Board. For this study, we examined the current status of continuing hospitalization judgement in Mental Health Review Board at the national level and aimed to determine the directions of improvement. METHODS: Using a qualitative case study as the research method, we interviewed 30 Mental Health Review Board members and analyzed the results. RESULTS: Each municipality had very different continuing hospitalization judgement methods. In our systematic review, which consisted of document inspection, we identified reliability problems due to limitations in Mental Health Review Board's operating systems, discharge orders, etc. Additionally, continuing hospitalization judgement needs to improve the objectivity, fairness, and effectiveness of their screening examinations. CONCLUSION: Based on the results of this study, we suggest policy proposals to improve these systems, such as standardizing examination processes, strengthening on-site inspections, increasing the independence and neutrality of judgment in Mental Health Review Board, building community mental health infrastructures, and establishing integrated management systems.
Hospitalization
;
Judgment
;
Jurisprudence
;
Mass Screening
;
Mental Health
;
Methods
;
Qualitative Research
5.A Case of Femoral Endarteritis Related to Using a Percutaneous Closure Device after Coronary Angiography.
Dai Yeol JOE ; Se Jun PARK ; Soo Jin KANG ; Byoung Joo CHOI ; So Yeon CHOI ; Myeong Ho YOON ; Seung Jea TAHK ; Joon Han SHIN
Korean Circulation Journal 2006;36(11):762-763
Percutaneous arterial closure devices allow earlier mobilization and discharge of patients after arterial catheterization than manual compression for achieving puncture site hemostasis. Our case is representative of Perclose(r) associated infections; our patient had a delayed presentation of a staphylococcal arterial infection that required arterial debridement and reconstruction. Physicians should be aware of this uncommon, but serious complication to expedite the evaluation and treatment of patients with suspected infections that can arise from using these devices.
Catheterization
;
Catheters
;
Coronary Angiography*
;
Debridement
;
Endarteritis*
;
Hemostasis
;
Humans
;
Punctures
6.Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation.
Hyoung Il KIM ; Seung Hee BAIK ; Jun Hwan YOO ; Dai Yeol JOE ; Jung Il PARK ; Hyun Woo LEE ; Seok Yun KANG ; Jun Ho JANG ; Joon Seong PARK ; Jin Hyuk CHOI ; Hugh Chul KIM
Korean Journal of Hematology 2006;41(4):259-265
BACKGROUND: The response rates and survival following allogeneic bone marrow transplantation (BMT) or immunosuppressive treatment were compared in severe aplastic anemia (SAA) and the prognostic factors related with survival identified. METHODS: Medical data of SAA patients, treated with BMT or immunosuppressive therapy (IST) at the Ajou University Hospital, between January 1995 and December 2005, were retrospectively analyzed. RESULTS: A total of 43 patients were evaluable; 18 (41.9%) were treated with IST (antithymocyte globulin plus cyclosporine A plus steroid) and 25 (58.1%) with allogeneic BMT. In the IST group, the response rate was 77.8% (2 complete and 12 partial remissions), with two treatment failures. As later complications, acute myeloid leukemia developed in 1 patient and myelodysplastic syndrome developed in 2. In the BMT group, the response rate was 92.0% (18 complete and 5 partial remissions) (P<0.001). Six patients developed grade II to III acute graft-versus-host-disease (GVHD) and 3 developed chronic GVHD. The median survival time in all patients was 60.27 months, and the 5-year survival rates were 61.0 and 81.9% in the IST and BMT groups, respectively (P=0.144). The factors influencing the overall survival were an age under 40-years and a positive treatment response. CONCLUSION: This study shows that allogeneic BMT, compared to IST, resulted in good response andoverall survival rates in patients with SAA. However, the overall survival rate between the two groups was statistically insignificant. Our study suggests that younger age SAA patients, with HLA-matched BMT donors, may benefit more from allogeneic BMT.
Anemia, Aplastic*
;
Bone Marrow Transplantation*
;
Bone Marrow*
;
Cyclosporine
;
Humans
;
Leukemia, Myeloid, Acute
;
Myelodysplastic Syndromes
;
Retrospective Studies
;
Survival Rate
;
Tissue Donors
;
Treatment Failure
7.Association between Glycated Hemoglobin A1c and Intraocular Pressure in Nondiabetic Subjects
Kyung O KANG ; Seong Heub JUN ; Kyung Suk SHIN ; Doo Yong SON ; Byung Wook YOO ; Sun Hee KIM ; Hyun JOE ; Sung Ho HONG ; Choo Yon CHO ; Hwang Sik SHIN ; Yong Jin CHO ; Jung Eun OH
Korean Journal of Family Practice 2019;9(1):59-63
BACKGROUND: Diabetic patients are known to have unusually high mean intraocular pressure (IOP); attributable to autonomic dysfunction and genetic factors. A recent study reported that diabetic complications occur in not only diabetes but also prediabetes. We performed this study to analyze the relationship between glycated hemoglobin A1c (HbA1c) levels and IOP in non-diabetics using electronic medical records at the health screening center of Soon Chun Hyang University Seoul Hospital.METHODS: We considered 16,643 individuals who visited the health screening center of Soon Chun Hyang University Seoul Hospital between November 2015 and September 2017. In total, 3,029 subjects were included in the study. Exclusion criteria included a history of hypertension, diabetes, stroke, cardiovascular disease, hepatitis (A-C), cancer, other disease, fasting blood glucose of 126 mg/dL or higher, HbA1c of 6.5% or higher, and individuals whose binocular IOP could not be measured. We categorized subjects into two groups; those with HbA1c less than or equal to 5.6%, and those with HbA1c greater than 5.6% and less than 6.5%. The mean IOP of each group was compared by gender.RESULTS: After adjusting for factors affecting IOP, analysis of variance was performed to analyze the relationship between HbA1c and IOP. There was no statistically significant difference between the HbA1c groups in males. However, there was a significant difference in IOP between females in the the higher and lower HbA1c groups.CONCLUSION: There was a statistically significant relationship between mean IOP and HbA1c in females without diabetes. Further research is needed with prospective and extensive data collection.
Blood Glucose
;
Data Collection
;
Diabetes Complications
;
Diabetes Mellitus
;
Electronic Health Records
;
Fasting
;
Female
;
Health Promotion
;
Hemoglobin A, Glycosylated
;
Hepatitis
;
Humans
;
Hypertension
;
Intraocular Pressure
;
Male
;
Mass Screening
;
Myocardial Infarction
;
Prediabetic State
;
Prospective Studies
;
Seoul
;
Telescopes
8.Management of Male Infertility with Coexisting Sexual Dysfunction: A Consensus Statement and Clinical Recommendations from the Asia-Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men’s Health and Aging (ASMHA)
Eric CHUNG ; Jiang HUI ; Zhong Cheng XIN ; Sae Woong KIM ; Du Geon MOON ; Yiming YUAN ; Koichi NAGAO ; Lukman HAKIM ; Hong-Chiang CHANG ; Siu King MAK ; Gede Wirya Kusuma DUARSA ; Yutian DAI ; Bing YAO ; Hwancheol SON ; William HUANG ; Haocheng LIN ; Quang NGUYEN ; Dung Ba Tien MAI ; Kwangsung PARK ; Joe LEE ; Kavirach TANTIWONGSE ; Yoshikazu SATO ; Bang-Ping JIANN ; Christopher HO ; Hyun Jun PARK
The World Journal of Men's Health 2024;42(3):471-486
Male infertility (MI) and male sexual dysfunction (MSD) can often coexist together due to various interplay factors such as psychosexual, sociocultural and relationship dynamics. The presence of each form of MSD can adversely impact male reproduction and treatment strategies will need to be individualized based on patients’ factors, local expertise, and geographical socioeconomic status. The Asia Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men’s Health and Aging (ASMHA) aim to provide a consensus statement and practical set of clinical recommendations based on current evidence to guide clinicians in the management of MI and MSD within the Asia-Pacific (AP) region. A comprehensive, narrative review of the literature was performed to identify the various forms of MSD and their association with MI. MEDLINE and EMBASE databases were searched for the following English language articles under the following terms: “low libido”, “erectile dysfunction”, “ejaculatory dysfunction”, “premature ejaculation”, “retrograde ejaculation”, “delayed ejaculation”, “anejaculation”, and “orgasmic dysfunction” between January 2001 to June 2022 with emphasis on published guidelines endorsed by various organizations. This APSSM consensus committee panel evaluated and provided evidence-based recommendations on MI and clinically relevant MSD areas using a modified Delphi method by the panel and specific emphasis on locoregional socioeconomic-cultural issues relevant to the AP region. While variations exist in treatment strategies for managing MI and MSD due to geographical expertise, locoregional resources, and sociocultural factors, the panel agreed that comprehensive fertility evaluation with a multidisciplinary management approach to each MSD domain is recommended. It is important to address individual MI issues with an emphasis on improving spermatogenesis and facilitating reproductive avenues while at the same time, managing various MSD conditions with evidence-based treatments. All therapeutic options should be discussed and implemented based on the patient’s individual needs, beliefs and preferences while incorporating locoregional expertise and available resources.
9.Efficacy of Itraconazole Melt-Extrusion Tablet One-week Therapy in Treatment of Hyperkeratotic Type of Tinea Pedis and/or Tinea Manus.
Kee Chan MOON ; Jai Kyoung KOH ; Baik Kee CHO ; Hyung Ok KIM ; Gun Su PARK ; Dae Gyu BYUN ; Jin Woo KIM ; In Kang JANG ; Jong Yuk YI ; Jae Bok JUN ; Tae Jin YOON ; Nack In KIM ; Kyu Suk LEE ; Chill Hwan OH ; Soo Nam KIM ; Sook Ja SON ; Yong Woo CHIN ; Dong Seok KIM ; Gwang Yeol JOE ; Won Woo LEE ; Kyung Sool KWON ; Dae Hun SUH ; Sang Eun MOON ; See Yong PARK ; Kea Jeung KIM ; Jong Suk LEE ; Eun So LEE ; Hyun Joo CHOI ; Eung Ho CHOI ; Ki Hong KIM ; Seung Hoon CHA ; Young Gull KIM ; Jung Hee HAHM ; Hae Young CHOI ; Sung Uk PARK ; Bang Soon KIM ; Sang Wahn KOO ; Byung Soo KIM ; Young Ho WON ; Han Uk KIM ; Eun Sup SONG ; Byoung Soo CHUNG ; Byung In RO ; Chang Kwun HONG ; Jagn Kue PARK ; Tae Young YOUN ; Hee Sung KIM ; Cheol Heon LEE ; Kwang Joong KIM ; Dae Won KOO ; Jong Min KIM ; Chang Woo LEE ; Hee Joon YU
Korean Journal of Dermatology 1999;37(8):1047-1056
BACKGROUND: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. METHODS: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. RESULTS: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea mauns were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50% decrease of the sum of the clinical symptom scores, was 79.3%(512/646). 3. Mycological cure rate, dafined as both culture and KOH negative at week 8, was 78.2%(244 /312). 4. 40(5.5%) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. CONCLUSION: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.
Absorption
;
Biological Availability
;
Fasting
;
Gastric Acid
;
Hospitals, General
;
Humans
;
Itraconazole*
;
Korea
;
Outpatients
;
Tablets
;
Tinea Pedis*
;
Tinea*
;
Treatment Failure