Objective To analyze the relationship between knee degenerative changes and gender-age changes and review the literature. Methods 2357 cases of knee joint X-ray films from January 2015 to October 2017 in all patients and health examination population in our hospital were retrospectively analyzed. All observers were grouped according to gender and age and divided into 5 groups according to age: 40 to 49 years old, 50 to 59 years old, 60 to 69 years old, 70 to 79 years old, and 80 years old or older. For all knee joints, the X-ray film was graded by the Kellgren & Lawrence classification method and was specifically divided into grade 0, grade I, grade Ⅱ, grade Ⅲ, and grade Ⅳ total 5 grades. Analyzed the ratio of all levels in each age group. Results Regardless of men or women, the degree of degeneration of knee joints increased with age, and in the same age group at all ages, the degree of female knee degeneration was higher than that of men. Conclusion The incidence of degenerative osteoarthritis of knee joint increases with age. Prophylaxis, early detection, early diagnosis and early treatment are all significant to improve the quality of life of patients, delay the progress of the disease as far as possible.