Objective To investigate the effect of methylprednisolone (MP) therapy on apoptosis of neurons in the paraventricular nucleus (PVN) after traumatic brain injury (TBI) in rats.Methods A total of 185 Wistar rats were divided into sham operation group (n =20),trauma control group (n =45),low-dose MP therapy group (n =50) and high-dose MP therapy group (n =70),according to the random number table.TBI models were induced by fluid percussion injury.TUNEL staining,immunohistochemistry and transmission electron microscope were used to detect PVN neuron number and apoptosis.Results Apoptotic neurons in the PVN were 0.7 ± 1.6,rare in sham operation group,whereas apoptotic neurons in trauma control group were firstly detected at 3 days and reached peak at 7 days (36.4 ± 18.8),with a slump of corticotropin-releasing hormone (CRH) for 208.0 ± 19.8.High-dose MP therapy markedly increased the neuron apoptosis (70.7±27.2),reduced CRH-positive cells (141.7 ±32.6),and increased short-term mortality (55％) when compared to trauma control group (all P ＜ 0.05).In contrast,low-dose MP greatly reduced PVN neuron apoptosis (17.6 ± 6.9),but increased CRH-positive cells (249.2 ±20.3) (P＜0.05) and decreased the short-term mortality (10％).Conclusions High-dose MP therapy increases neuronal apoptosis in PVN and short-term mortality after TBI.However,low-dose MP protects PVN neurons against TBI-induced apoptosis and reduces the mortality.

Objective To observe the application effect of check-in supervision intervention based on Wechat APP in minimally invasive cerebrovascular intervention.Methods Patients treated with minimally invasive cerebrovascular intervention in our hospital were selected as study objects.Ac-cording to the implementation time of the check-in supervision intervention based on Wechat APP,55 patients admitted before the implementation were included in routine group,and 55 patients admitted after the implementation were included in Wechat group.Neurological function recovery[National In-stitute of Health Stroke Scale(NIHSS)and Modified Edinburgh-Scandinavian Stroke Scale(MESSS)],self-management ability[Scale of Health Self-management Skill for Adults(AHSMARS-Ⅱ)],medica-tion compliance,exercise compliance,quality of life[general quality of life inventory(GQOLI-74)]and nursing satisfaction were compared between the two groups.Results After intervention,NIHSS and MESS scores in the Wechat group were significantly lower than those in the conventional group,AHSMARE-Ⅱ scores,medication compliance,exercise compliance,GQOLI-74 scores and total nursing satisfaction were significantly higher than those in the conventional group(P＜0.05).Conclusion The check-in supervision intervention mode based on Wechat APP can effectively improve the quality of home service for patients with minimally invasive cerebrovascular intervention after surgery,and improve pa-tients'self-management ability and compliance.

Objective To observe the application effect of check-in supervision intervention based on Wechat APP in minimally invasive cerebrovascular intervention.Methods Patients treated with minimally invasive cerebrovascular intervention in our hospital were selected as study objects.Ac-cording to the implementation time of the check-in supervision intervention based on Wechat APP,55 patients admitted before the implementation were included in routine group,and 55 patients admitted after the implementation were included in Wechat group.Neurological function recovery[National In-stitute of Health Stroke Scale(NIHSS)and Modified Edinburgh-Scandinavian Stroke Scale(MESSS)],self-management ability[Scale of Health Self-management Skill for Adults(AHSMARS-Ⅱ)],medica-tion compliance,exercise compliance,quality of life[general quality of life inventory(GQOLI-74)]and nursing satisfaction were compared between the two groups.Results After intervention,NIHSS and MESS scores in the Wechat group were significantly lower than those in the conventional group,AHSMARE-Ⅱ scores,medication compliance,exercise compliance,GQOLI-74 scores and total nursing satisfaction were significantly higher than those in the conventional group(P＜0.05).Conclusion The check-in supervision intervention mode based on Wechat APP can effectively improve the quality of home service for patients with minimally invasive cerebrovascular intervention after surgery,and improve pa-tients'self-management ability and compliance.