PURPOSE: This study aimed to identify the factors affecting stress among resort workers. METHODS: The subjects of the study were 199 resort workers in a province of Korea. Data were collected using self-administered questionnaires that were completed between November 16, 2017 and January 19, 2018. The questionnaire consisted of stress and health promoting behavior and its sub-areas such as health responsibilities, physical activity, nutrition, spiritual growth, interpersonal relations, and stress management. Using the SPSS 23.0 program, descriptive statistics, t-test, ANOVA, correlation analysis, and multiple regression analysis were conducted. RESULTS: The mean score of the stress levels of resort workers was 2.3±0.98 out of a maximum score of 5. A multiple regression analysis revealed that gender, spiritual growth, and stress management were statistically significant factors in the model (p < .001), with an explanatory power of 35%. CONCLUSION: Stress levels were considerably high in resort workers. This study suggests that nursing interventions are needed to reduce stress levels and enhance health promoting behavior, especially spiritual growth and stress management, at both an individual and organizational level.
Health Behavior ; Health Promotion ; Health Resorts ; Interpersonal Relations ; Korea ; Motor Activity ; Nursing

PURPOSE: This study aimed to identify the factors affecting stress among resort workers. METHODS: The subjects of the study were 199 resort workers in a province of Korea. Data were collected using self-administered questionnaires that were completed between November 16, 2017 and January 19, 2018. The questionnaire consisted of stress and health promoting behavior and its sub-areas such as health responsibilities, physical activity, nutrition, spiritual growth, interpersonal relations, and stress management. Using the SPSS 23.0 program, descriptive statistics, t-test, ANOVA, correlation analysis, and multiple regression analysis were conducted. RESULTS: The mean score of the stress levels of resort workers was 2.3±0.98 out of a maximum score of 5. A multiple regression analysis revealed that gender, spiritual growth, and stress management were statistically significant factors in the model (p < .001), with an explanatory power of 35%. CONCLUSION Stress levels were considerably high in resort workers. This study suggests that nursing interventions are needed to reduce stress levels and enhance health promoting behavior, especially spiritual growth and stress management, at both an individual and organizational level.

PURPOSE: Rathke’s cleft cyst (RCC) is an asymptomatic benign lesion. With increased interest in pediatric endocrinology, the prevalence of RCCs in children is also increasing. However, the clinical relevance and proper management of RCC is not well defined in children. Therefore, we investigated the clinical manifestations and radiologic features of RCC in children and adolescents, as well as the natural progression of RCC. METHODS: We retrospectively reviewed the medical records of 91 children and adolescents with RCC diagnosed with magnetic resonance imaging (MRI) in Severance Children’s Hospital from January 2006 to December 2015. The clinical, hormonal, and imaging findings were analyzed in patient groups classified according to age. The size of each cyst was assessed in sixty patients who underwent follow-up MRI during the 2 years. RESULTS: Female patients were predominant (64 vs. 27). The common clinical features at presentation were endocrine dysfunction (59.3%), headache (23.0%), and dizziness (4.4%). Symptoms related to endocrine disorders were more frequent in younger patients. In 7 patients managed surgically, the cysts were significantly larger and more frequently located in the suprasellar region. Of 60 nonsurgical patients with a follow-up MRI performed within 2 years after the diagnosis, the RCC size increased in about 26.7% (n=16). CONCLUSION: Although 94.4% of the patients with RCC had clinical symptoms, surgery was performed in only about 7.5% of patients. RCC is associated with pituitary insufficiency, thus, baseline and follow-up endocrine function tests are required. Additionally, regular MRI follow-up is required in long-term period to monitor change in size.
Adolescent* ; Central Nervous System Cysts ; Child* ; Diagnosis ; Dizziness ; Endocrine System Diseases ; Endocrinology ; Female ; Follow-Up Studies ; Headache ; Humans ; Hypopituitarism ; Magnetic Resonance Imaging ; Medical Records ; Natural History ; Prevalence ; Retrospective Studies

Purpose: The clinical characteristics of headaches vary by age among pediatric patients. Red flag signs are key factors in differentiating secondary headaches and should be considered in the context of the patient’s age. Methods: This study involved a retrospective chart review of pediatric patients presenting with headaches. Patients were categorized by age into three groups: pre-school age (under 6 years), school-age (6 to 12 years), and adolescence (over 12 years). Demographic data, headache characteristics, laboratory findings, and neuroimaging results were evaluated. Overall, 17 potential red flags were assessed. Results: A total of 687 patients were included, of whom 102 were of pre-school age, 314 were school-aged, and 271 were adolescents. The frequency of overweight/obesity was found to increase with age. The pre-school age group experienced a shorter period from symptom onset to presentation and a briefer duration of pain. In contrast, adolescents displayed a longer period from symptom onset, a greater frequency of headaches occurring at least three times per week, and a higher rate of headache episodes lasting over 3 days. Children under 6 years old were more commonly diagnosed with secondary headaches than older children. Across age groups, secondary headaches were suspected when systemic symptoms such as fever were present, when the headache had a sudden onset, when the patient responded poorly to medication, or when abnormal neurological signs and symptoms were observed. Conclusion The clinical features of pediatric patients vary by age group. Clinicians should consider red flag signs in the context of patient age and individual characteristics.

PURPOSE: Previous retrospective studies suggest that anaplastic lymphoma kinase (ALK) mutation-positive (ALK+) non-small cell lung cancer (NSCLC) patients are sensitive to pemetrexed. To determine its efficacy, we retrospectively evaluated clinical outcomes of pemetrexed-based chemotherapy in patients with ALK+ NSCLC. MATERIALS AND METHODS: We identified 126 patients with advanced, ALK+ NSCLC who received first-line cytotoxic chemotherapy. We compared response, progression-free survival (PFS), and overall survival (OS) rates according to chemotherapy regimens. Furthermore, we evaluated intracranial time to tumor progression (TTP) and proportion of ALK+ cells as prognostic factors. RESULTS: Forty-eight patients received pemetrexed-based chemotherapy, while 78 received other regimens as first-line treatment. The pemetrexed-based chemotherapy group showed superior overall response (44.7% vs. 14.3%, p < 0.001) and disease control (85.1% vs. 62.3%, p=0.008) rates. The pemetrexed-based chemotherapy group also exhibited longer PFS (6.6 months vs. 3.8 months, p < 0.001); OS rates were not significantly different. The lack of exposure to second-generation ALK inhibitors and intracranial metastasis on initial diagnosis were independent negative prognostic factors of OS. Intracranial TTP was similar between the treatment groups (32.7 months vs. 35.7 months, p=0.733). Patients who harbored a greater number of ALK+ tumor cells (≥70%) showed prolonged OS on univariate analysis (not reached vs. 44.8 months, p=0.041), but not on multivariate analysis (hazard ratio: 0.19, 95% confidence interval: 0.03–1.42; p=0.106). CONCLUSION: Pemetrexed-based regimens may prolong PFS in patients with ALK+ NSCLC as a first-line treatment, but are not associated with prolonged OS. Exposure to second-generation ALK inhibitors may improve OS rates in patients with ALK+ NSCLC.
Adult ; Aged ; Antineoplastic Agents/*therapeutic use ; Carcinoma, Non-Small-Cell Lung/*drug therapy/enzymology/mortality ; Disease-Free Survival ; Female ; Humans ; Lung Neoplasms/*drug therapy/enzymology/mortality ; Male ; Middle Aged ; Mutation ; Pemetrexed/*therapeutic use ; Receptor Protein-Tyrosine Kinases/genetics ; Retrospective Studies ; Survival Rate ; Treatment Outcome