1.The effect of dietary fats of immune response in sublethally irradiated rats.
Soon Hwan OH ; Dong Soo KIM ; Hae Won NAM ; Juhn Kyu LOH
Journal of the Korean Pediatric Society 1991;34(11):1494-1504
No abstract available.
Animals
;
Dietary Fats*
;
Radiotherapy
;
Rats*
2.Radiotherapy in Hodgkin's disease.
Young Hwan PARK ; Chang Ok SUH ; Gwi Eon KIM ; John Kyu LOH JUHN
Journal of the Korean Cancer Association 1992;24(2):277-287
No abstract available.
Hodgkin Disease*
;
Radiotherapy*
3.Optimization of Dose Distribution for High Dose Rate Intraluminal Therapy.
Sung Sil CHU ; Gwi Eon KIM ; Juhn Kyu LOH
Journal of the Korean Society for Therapeutic Radiology 1994;12(2):243-252
The use of high dose rate remote afterloading system for the treatment of intraluminal lesions necessitates the need for a more accurate of dose distributions around the high intensity brachytherapy sources, doses are often prescribed to a distance of few centimeters from the linear source, and in this range the dose distribution is very difficult to assess. Accurated and optimized dose calculation with stable numerical algorithms by PC level computer was required to treatment intraluminal lesions by high dose rate brachytherapy system. The exposure rate from sources was calculated with Sievert integral and dose rate in tissue was calculated with Meisberger equation. An algorithm for generating a treatment plan with optimized dose distribution was developed for high dose rate intraluminal radiotherapy. The treatment volume becomes the locus of the constrained target surface points that is the specified radial distance from the source dwelling positions. The treatment target volume may be alternately outlined on a x-ray film of the implant dummy sources. The routine used a linear programming formulism to compute which dwell time at each position to irradiate the constrained dose rate at the target surface points whiles minimizing the total volume integrated dose to the patient. The exposure rate and the dose distribution to be confirmed the result of calculation with algorithm were measured with film dosimetry, TLD and small size ion chambers.
Brachytherapy
;
Film Dosimetry
;
Humans
;
Programming, Linear
;
Radiotherapy
;
X-Ray Film
4.Effectiveness of postoperative adjuvant treatment between radiation alone and chemotherapy plus radiation in locally advanced breast cancer.
Kyung Ran PARK ; John Kyu LOH JUHN ; Chang Ok SUH ; Gwi Eon KIM ; Eun Hee KOH ; Byung Soo KIM ; Kyung Sik LEE
Journal of the Korean Cancer Association 1991;23(1):107-119
No abstract available.
Breast Neoplasms*
;
Breast*
;
Drug Therapy*
5.Phase II trial of 5-FU, etoposide, cisplatin (FEP) combination chemotherapy in unresectable non-small cell lung cancer.
Jin Hyuk CHOI ; Hyun Cheol CHUNG ; Dong Jip KIM ; Je Yol OH ; Joon CHANG ; Eun Hee KOH ; Joo Hang KIM ; Jae Kyung RHO ; Sung Kyu KIM ; Won Young LEE ; Gwi Eon KIM ; John Kyu LOH JUHN
Journal of the Korean Cancer Association 1991;23(1):120-130
No abstract available.
Carcinoma, Non-Small-Cell Lung*
;
Cisplatin*
;
Drug Therapy, Combination*
;
Etoposide*
;
Fluorouracil*
6.Parotid Gland Sparing Radiotherapy Technique Using 3-D Conformal Radiotherapy for Nasopharyngeal Carcinoma.
Ji Hoon LIM ; Gwi Eon KIM ; Ki Chang KEUM ; Chang Ok SUH ; Sang Wook LEE ; Hee Chul PARK ; Jae Ho CHO ; Sang Hoon LEE ; Sei Kyung CHANG ; Juhn Kyu LOH
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2000;18(1):1-10
PURPOSE: Although using the high energy photon beam with conventional parallel-opposed beams radio-therapy for nasopharyngeal carcinoma, radiation-induced xerostomia is a troublesome problem for patient. We conducted this study to explore a new parotid gland sparing technique in 3-D conformal radiotherap (3-D CRT) in an effort to prevent the radiation-induced xerostomia. MATERIALS AND METHODS: We performed three different planning for four clinically node-negative naso-phar yngeal cancer patients with different location of tumor(intracranial extension, nasal cavity extension, oropharyngeal extension, parapharyngeal extension), and intercompared the plans. Total prescription dos <. Was 70.2 Gy to the isocenter, For plan-A, 2-D parallel opposing fields, a conventional radiotherapy technique, were employed. For plan-B, 2-D parallel opposing fields were used up until 54 Gy an < 3 afterwards 3-D non-coplanar beams were used. For plan-C, the new technique, 54 Gy was delivered b r 3-D conformal 3-port beams (AP and both lateral ports with wedge compensator; shielding both superficial lobes of parotid glands at the AP beam using BEV) from the beginning of the treatment and early spinal cord block (at 36 Gy) was performed. And bilateral posterio r necks were treated with electron after 36 Gy. After 54 Gy, non-coplanar beams were used for cone-down plan. We intercompared dose statistic; Dmax, Dmin, Dmean, D95, D05, V95, V05, Volume receiving 46 Gy) and dose volume histograms (DVH) of tumor and normal tissues and NTCP values of parotid glands for the above three plans. RESULTS: For all patients, the new technique (plan-C) was comparable or superior to the other plans in target volume isodose distribution and dose statistics and it has more homogenous target volume, coverage. The new technique was most superior to the other plans in parotid glands sparing (volume receiving 46 Gy: 100, 9 B, 69% for each plan-A, B and C). And it showed the lowest NTCP value of parotid glands in all patients (range of NTCP; 96-100%, 79-99%, 51-72% for each plan-A, B and C). CONCLUSION: We conclude that the new technique employing 3-D conformal radiotherapy at the beginning of radiotherapy and cone down using non-coplanar beams with early spinal cord block is highly recommended to spare parotid glands for node-negative nasopharygeal cancer patients.
Humans
;
Nasal Cavity
;
Neck
;
Parotid Gland*
;
Prescriptions
;
Radiotherapy*
;
Radiotherapy, Conformal*
;
Spinal Cord
;
Xerostomia
7.Management of rocoregional recurrent breast cancer.
Kyung Ran PARK ; Jong Young LEE ; Chang Geol LEE ; Chang Ok SUH ; John Kyu LOH JUHN ; Gwi Eon KIM ; Soo Gon KIM ; Won Yong OH ; Eun Hee KOH ; Byung Soo KIM
Journal of the Korean Cancer Association 1992;24(5):684-694
No abstract available.
Breast Neoplasms*
;
Breast*
8.A phase II trial of combined sequential FP (5-FU+cisplatin) chemotheraphy and radiotherapy in locally advanced unresectable esophageal cancer.
Jong Won HA ; Hyun Cheol CHUNG ; Dong Lip KIM ; Jin Hyuk CHOI ; Nae Choon YOO ; Eun Hee KOH ; Joo Hang KIM ; Jae Kyung ROH ; Gwi Eon KIM ; John Kyu LOH JUHN ; Byung Soo KIM
Journal of the Korean Cancer Association 1991;23(2):307-314
No abstract available.
Esophageal Neoplasms*
;
Radiotherapy*
9.Treatment Result in Advanced T3 and T4 Glottic Carcinoma: YUMC Experience.
Hyun Soo SHIN ; Hyung Sik LEE ; Eun Ji CHUNG ; Gwi Eon KIM ; Juhn Kyu LOH ; Chang Ok SUH ; Kwang Moon KIM ; Won Pyo HONG
Journal of the Korean Society for Therapeutic Radiology 1991;9(1):73-80
Between January 1980 and September 1988, 68 patients with advanced T3 & T4 glottic carcinoma were treated with RT and surgery/RT in the Department of Radiation Oncology, Yonsei Cancer Center and ENT, Yonsei University College of Medicine. The mean age was 60 years old (range 33 to 79 year old). The 34 patients were treated with irradiation alone, and the remaining 34 patients with surgery and irradiation. Initial nodal presentation was 37% (25/68); 31% (11/34) in RT alone group and 41% (14/34) in combined treatment group. The minimum follow-up was 2 years. The local control rate after treatment was 47% in RT alone group and 65% in combined treatment group; 57% for node negative and 27% for node positive patients treated with RT alone; 65% for node negative and 64% for node positive patients treated with combined treatment. The treatment failure was observed in 30 patients; 14 patients for primary local failure, 6 patients for regional nodal failure, 6 patients for local and regional failure, 26 patients for primary failure and/or distant metastasis, and 2 patient for regional failure and/or distant metasasis. The overall 5-year survival rate was 57%; 37% in RT alone group and 76% in combined treatment group; 55% for node negative and 20% for node positive patients treated with RT alone; 73% for node negative and 77% for node positive patients treated with combined treatment. In conclusion, the combined treatment groups in the treatment of advanced T3 and T4 glottic cancer showed the better results in local control rates and 5-year actuarial survival rates than RT alone group. We suggest that total laryngectomy and postoperative RT in the most patients of advanced glottic cancer were performed. However, in cases of node negative patients, RT alone is prefer as a treatment modality over combined surgery and RT since the treatment results were comparable and furthermore functional preservation could be achieved.
Follow-Up Studies
;
Humans
;
Laryngectomy
;
Middle Aged
;
Neoplasm Metastasis
;
Radiation Oncology
;
Survival Rate
;
Treatment Failure
10.Effects of Radiofrequency Induced local Hyperthermia on Normal Canine Liver.
Chang Ok SUH ; John Juhn Kyu LOH ; Jin Sil SUNG ; Sun Rock MOON ; Hyung Sik LEE ; Hyun Soo SHIN ; Sung Sil CHU ; Gwi Eon KIM ; Chan Il PARK ; Eun Kyung HAN
Journal of the Korean Society for Therapeutic Radiology 1991;9(1):37-46
In order to assess the effects of radiofrequency-induced local hyperthermia on the normal liver, histopathologic findings and biochemical changes after localized hyperthemia in canine liver were studied. Hyperthermia was externally administered using the Thermotron RF-8 (Yamamoto Vinyter Co., Japan; Capacitive type heating machine) with parallel opposed electrodes. Thirteen dogs were used and allocated into one control group (N=3) and two treatment groups according to the treatment temperature. GroupI(N=5) was heated with 42.5+/-0.5degree C for 30 minutes, and GroupII(N=5) was heated with 45+/-0.5degree C for 15-30 minutes. Samples of liver tissue were obtained through a needle biopsy immediately afterhyperthermia and 7, 14 and 28 days after treatment and examined for SGOT, SGPT and alkaline phosphatase. Although SGOT and SGPT were elevated after hyperthermia in both groups (three of five in each group), there was no liver cell necrosis or hyperthermia related mortality in GroupI. A hydropic swelling of hepatocytes was prominent histologic finding. Hyperthermia with 45degree C for 30 minutes was fatal and showed extensive liver cell necrosis. In conclusion, liver damage day heat of 42.5+/-0.5degree C for 30 minutes is reversible, and liver damage by heat of 45+/-0.5degree C for 30 minutes can be fatal or irreversible. However, these results cannot be applied directly to human trial. Therefore, in order to apply hyperthermic treatment on human liver tumor safely, close observation of temperature with proper thermometry is mandatory. Hyperthermic treatment should be confined to the tumor area while sparing a normal liver as much as possible.
Alanine Transaminase
;
Alkaline Phosphatase
;
Animals
;
Aspartate Aminotransferases
;
Biopsy, Needle
;
Dogs
;
Electrodes
;
Fever
;
Heating
;
Hepatocytes
;
Hot Temperature
;
Humans
;
Hyperthermia, Induced*
;
Japan
;
Liver*
;
Mortality
;
Necrosis
;
Thermometry