Latex allergy is a known cause of allergic contact dermatitis. It produces mild symptoms, including skin rash and itching, which usually subside in a few days. However, latex allergy can also induce anaphylaxis, a severe type I hypersensitivity reaction that can cause urticaria, angioedema, hypotension, tachycardia, and bronchospasm. We report a case of anaphylactic shock during gastric cancer surgery in a patient with no previous allergic history. Surgery was suspended when hypotension, tachycardia, and wheezing developed. A thorough workup revealed that the patient had a latex allergy. The patient subsequently underwent curative gastrectomy performed with latex-free procedures.
Anaphylaxis ; Angioedema ; Bronchial Spasm ; Dermatitis, Allergic Contact ; Exanthema ; Gastrectomy ; Humans ; Hypersensitivity, Immediate ; Hypotension ; Latex ; Latex Hypersensitivity ; Pruritus ; Respiratory Sounds ; Stomach Neoplasms ; Tachycardia ; Urticaria

BACKGROUND: There have been evidences that inactivation of tumor supressor genes such as p16 and pRb develops human malignancies. p16 inhibits the cyclin D/cyclin-dependant kinase 4 complex which phosphorylates pRb, thus negatively regulating cell cycle progression. Rb gene inactivation has been observed in various tumor and reported to be reciprocally correlated with p16 expression. The purpose of this study is to evaluate aberrant expression of p16 and pRb in acute leukemia by immunohistochemial stain in clot or biopsy section of the bone marrow. METHODS: For detection of p16 and pRb, immunohistochemical staining with anti-human mouse monoclonal antibodies to p16 and pRb were done on 62 bone marrow paraffin sections from leukemic patients. In acute lymphoblastic leukemia (ALL), immunophenotyping was performed with indirect immunofluorescent assay and clinical parameters were analyzed depending on status of p16 expression. RESULTS: In 28 cases (45%), abnormal expression of p16 or pRb were observed. Twenty three of those cases (37%) showed aberrancy only in one protein, in which case, staining intensity was generally more stronger than that of normal expression in both proteins. The proportion of abnormal p16 expression was 30% and 15%, and that of pRb was 30% and 36% in ALL and in acute myelocytic leukemia, respectively. There was no significant clinical correlation between aberrancy of p16 and clinical parameters of acute leukemia. CONCLUSION: Our results suggest that loss of the p16 and pRb function may contribute to pathogenesis of acute leukemia. Further study is needed in more cases of acute leukemia to evaluate clinical significance of p16 or pRb aberrancy, particularly in ALL.
Animals ; Antibodies, Monoclonal ; Biopsy ; Bone Marrow ; Cell Cycle ; Cyclins ; Genes, Retinoblastoma ; Humans ; Immunophenotyping ; Leukemia* ; Leukemia, Myeloid, Acute ; Mice ; Paraffin ; Phosphotransferases ; Precursor Cell Lymphoblastic Leukemia-Lymphoma

No abstract available.
Follow-Up Studies* ; Prognosis* ; Stomach Neoplasms* ; Stomach*

coxon test. All the values of experimental groups are significantly lower than those of control, and the vaules among the experimental groups significantly differ from each other. Alkaline phosphatase level was identical order with the viable cell rate. SEM examination revealed that the PDL fibroblasts adherent on culture dish (control) and group A were spindle-shaped, but on group B and C, the cells were round-shaped without processes.
Alkaline Phosphatase ; Collagen* ; Fibroblasts* ; Humans* ; Membranes*

Cells, Cultured ; Cholera Toxin ; Culture Media ; Cytoplasm ; Desmosomes ; Dimethyl Sulfoxide ; Epidermal Growth Factor ; Gingiva ; Humans ; Keratinocytes ; Organelles ; Surgery, Oral ; Transferrin ; Transplants ; Vestibuloplasty

With the age of exposure to illegal substances decreasing and abuse of drugs such as methamphetamine increasing, substance abuse is no longer limited to adults. We report a Korean case of a 17-year-old girl with acute methamphetamine poisoning. The girl visited the emergency department for vomiting and loss of consciousness, with needle marks found on both arms. QT prolongation was confirmed on the initial electrocardiogram, so that we suspected drug addiction and proceeded with toxicologic tests. A lethal dose of methamphetamine was confirmed. We discontinued QT prolonging drugs, and closely monitored the girl in the pediatric emergency intensive care unit until the QT prolongation was resolved. This case highlights the recognition of pediatric methamphetamine poisoning in emergency departments.

PURPOSE: To examine the correlation of depression with Internet use and body image perception, and to analyze the risk factors of depression in a total of 920 students in Seoul, Korea. METHODS: Students were recruited by contacting school principals and teachers and were encouraged to fill out a self-report questionnaire designed specifically for this study in July of 2008. RESULTS: Female participants had an increased risk for depression than did male participants (adjusted odds ratio [aOR], 1.790; 95% confidence interval [CI], 1.330–2.410, P<0.001). Older students were more susceptible to depression (aOR, 1.246; 95% CI, 1.115–1.392, P<0.001). Longer daily Internet use and more frequent Internet use were analyzed as risk factors for depression. No physical activity was a risk factor for depression (aOR, 0.392; 95% CI, 1.264–4.526, P=0.014). Dissatisfaction with one's body image increased the risk for depression (aOR, 1.373; 95% CI, 1.169–1.613; P<0.001). Obesity and perception of body image showed no significant relationship with increased risk for depression. CONCLUSION: Prevalence of depression was 13.8% in adolescents in Seoul, Korea, in July 2008. Female sex, age, daily Internet use duration, weekly Internet use frequency, physical activity, and dissatisfaction with one's body image independently increased risk of depression.
Adolescent* ; Body Image* ; Depression* ; Female ; Humans ; Internet* ; Korea ; Male ; Motor Activity ; Obesity ; Odds Ratio ; Prevalence ; Risk Factors ; Seoul ; Surveys and Questionnaires

PURPOSE: To examine the correlation of depression with Internet use and body image perception, and to analyze the risk factors of depression in a total of 920 students in Seoul, Korea. METHODS: Students were recruited by contacting school principals and teachers and were encouraged to fill out a self-report questionnaire designed specifically for this study in July of 2008. RESULTS: Female participants had an increased risk for depression than did male participants (adjusted odds ratio [aOR], 1.790; 95% confidence interval [CI], 1.330–2.410, P<0.001). Older students were more susceptible to depression (aOR, 1.246; 95% CI, 1.115–1.392, P<0.001). Longer daily Internet use and more frequent Internet use were analyzed as risk factors for depression. No physical activity was a risk factor for depression (aOR, 0.392; 95% CI, 1.264–4.526, P=0.014). Dissatisfaction with one's body image increased the risk for depression (aOR, 1.373; 95% CI, 1.169–1.613; P<0.001). Obesity and perception of body image showed no significant relationship with increased risk for depression. CONCLUSION: Prevalence of depression was 13.8% in adolescents in Seoul, Korea, in July 2008. Female sex, age, daily Internet use duration, weekly Internet use frequency, physical activity, and dissatisfaction with one's body image independently increased risk of depression.
Adolescent* ; Body Image* ; Depression* ; Female ; Humans ; Internet* ; Korea ; Male ; Motor Activity ; Obesity ; Odds Ratio ; Prevalence ; Risk Factors ; Seoul ; Surveys and Questionnaires

Background: Inter-hospital transfers of severely injured patients are inevitable due to limited resources. We investigated the association between inter-hospital transfer and the prognosis of pediatric injury using the Korean multi-institutional injury registry. Methods: This retrospective observational study was conducted from January 2013 to December 2017; data for hospitalized subjects aged < 18 years were extracted from the Emergency Department-based Injury in Depth Surveillance database, in which 22 hospitals are participating as of 2022. The survival rates of the direct transfer group and the interhospital transfer group were compared, and risk factors affecting 30-day mortality and 72-hour mortality were analyzed. Results: The total number of study subjects was 18,518, and the transfer rate between hospitals was 14.5%. The overall mortality rate was 2.3% (n = 422), the 72-hour mortality was 1.7% (n = 315) and the 30-day mortality rate was 2.2% (n = 407). The Kaplan-Meier survival curve revealed a lower survival rate in the inter-hospital transfer group than in the direct visit group (log-rank, P < 0.001). Cox proportional hazards regression analysis showed that interhospital transfer group had a higher 30-day mortality rate and 72-hour mortality (hazard ratio [HR], 1.681; 95% confidence interval [CI], 1.232–2.294 and HR, 1.951; 95% CI, 1.299–2.930) than direct visit group when adjusting for age, sex, injury severity, and head injury. Conclusion Among the pediatric injured patients requiring hospitalization, inter-hospital transfer in the emergency department was associated with the 30-day mortality rate and 72-hour mortality rate in Korea.

BACKGROUND: Methylmethacrylate monomer (MN) bone cement is commonly employed in orthopedic procedures, particularly total hip and knee replacement, to anchor prosthetic devices to bone. Numerous cardiopulmonary complications can occur just after injection of MN. And MN produces direct relaxation of vascular smooth muscle in vitro. The purpose of this study was to determine if MN could have relaxation effect in tracheal smooth muscle too. METHODS: Each ring of rat trachea was suspended on wire supports in a bath with Tris Tyrode solution. Dose response curves of MN were recorded after contraction of tracheal ring with acethylcholine (Ach) 10(-5) M or cabachol (Cch) 10(-8) M. MN was administered in denuded tracheal rings and compared it's effect with intact tracheal rings to see the effect of epithelium for contraction. And MN dose response curves were recorded after pretreatment of nitric oxide synthase inactivator (L-NAME), muscarinic receptor blocker (atropine), beta-adrenaline receptor blocker (propranolol), adenylyl cyclase inhibitor (SQ22536) respectively. The effects of MN on cellular Ca2+ and K+ migration in rat tracheal preparations were studied. RESULTS: MN significantly inhibited acetylcholine or carbachol induced contractions of tracheal rings dose-dependently (P < 0.05). This relaxation effect of MN was not recovered in denuded tracheal rings. And pretreatment with L-NAME, propranolol, atropine, SQ22536 or tetraethylammonium respectively did not recover the relaxation effect of MN. MN inhibited both intracellular calcium release and extracelluar calcium influx. CONCLUSIONS: The relaxation effects of MN on rat tracheal rings are not related with epithelium, nitric oxide, muscarinic, or beta-adrenergic receptor. Methylmethacrylate monomer inhibits both intracellular calcium release and extracelluar calcium influx.
Acetylcholine ; Adenylyl Cyclases ; Animals ; Atropine ; Baths ; Calcium ; Carbachol ; Epithelium ; Hip ; Knee ; Methylmethacrylate* ; Muscle, Smooth ; Muscle, Smooth, Vascular ; NG-Nitroarginine Methyl Ester ; Nitric Oxide ; Nitric Oxide Synthase ; Orthopedic Procedures ; Propranolol ; Rats* ; Receptors, Muscarinic ; Relaxation ; Tetraethylammonium ; Trachea