1.Serum vitamin D levels in postmenopausal women with type 2 diabetes mellitus.
Lingjia LIU ; Ying HU ; Juanxia CHUI ; Yuhang HU ; Bichen WU ; Xin SU
Journal of Central South University(Medical Sciences) 2013;38(10):1051-1056
OBJECTIVE:
To investigate the correlation between serum vitamin D levels and index of glucose and lipid metabolism in postmenopausal women with type 2 diabetes mellitus (T2DM).
METHODS:
A total of 44 postmenopausal women with T2DM and 41 healthy postmenopausal women were matched with age, body mass index and menopausal duration. The serum vitamin D was detected by enzyme-linked immuno-sorbent assay (ELISA).
RESULTS:
Compared with the control group, the level of 25(OH)D3 in postmenopausal women with T2DM was lower, with no statistical significance. Multiple regression analysis revealed that only BMI(bj'=-0.372, P<0.05) was independently related to 25(OH)D3 with statistical significance. The percentages of 25(OH)D3 deficiency in all subjects in the control group and in the T2DM group were 84.7%, 80.5%, and 88.6%, respectively. The 25(OH)D3 deficiency in the T2DM group was more prevalent than that in the control group, with no statistical difference (P=0.372). The binary logistic regression analysis showed the serum 25(OH)D3 level was not related to the risk of diabetes.
CONCLUSION
Compared with the control group, a lower 25(OH)D3 level and a higher rate of 25(OH)D3 deficiency is found in T2DM subjects. When rectified by BMI, these is no significant difference. In postmenopausal women, hypovitaminosis D is associated with obesity and dyslipidemia, but not with the risk of T2DM.
Body Mass Index
;
Calcitriol
;
blood
;
Case-Control Studies
;
Diabetes Mellitus, Type 2
;
blood
;
Female
;
Humans
;
Postmenopause
;
Prevalence
;
Vitamin D Deficiency