This paper introduced the concept and prevalence of frailty, as well as the concept and mechanism of exercise therapy. For the frailty, there were various modes of exercise therapy, and several exercise prescriptions were reported.

Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle and strength with a risk of adverse outcomes such as physical disability, poor quality of life and death. Skeletal muscle is the most important locomotive organ and energy metabolism organization. Patients with type 2 diabetes mellitus ( T2DM) were much likely to suffer sarcopenia due to impaired insulin secretion. Resistance training is an effective method to treat sarcopenia by far, and more it is more effectively to control the blood glucose compared with aerobic exercise. This thesis will summarize the pathogenetic mechanism of T2DM complicated with sarcopenia, and the function mechanism, methods and precautions of the resistance training, to provide reasonable and effective kinematic scheme for patients with T2DM and sarcopenia.