In the study of the relationship between cells overloading and the formation, regeneration and growth of bone, the text discussed osteoblasts express IGF-1 variation under overloading environment. The research of overloading on cellular level may elucidate the mechanical effect on the formation, regeneration and growth of bone and the mechanism of cell response in bone.
Animals ; Humans ; Insulin-Like Growth Factor I ; biosynthesis ; genetics ; Osteoblasts ; cytology ; metabolism ; Osteogenesis ; RNA, Messenger ; biosynthesis ; genetics ; Stress, Mechanical ; Weight-Bearing ; physiology