Objective To study the expression ofinterleukin 10(IL-10) and interleukin 17(IL-17)in patients with acute gastritis,and analyze the clinical significance.Methods The expression of IL-10 and IL-17 in the serum of 58 patients with acute gastritis (gastritis group) and 40 healthy cases (control group) was detected by ELISA.The patients in gastritis group included 23 patients of slight degree,18 patients of middle degree and 17 patients of severe degree.Results The level of IL-10 in gastritis group [(108.321 ±12.302) ng/L] was significantly higher than that in control group [(17.883 ± 13.802) ng/L] (t =18.143,P ＜ 0.01).The level of IL-17 in gastritis group [(127.418 ± 11.410) ng/L] was significantly higher than that in control group [(30.335 ± 14.549) ng/L] (t =22.493,P ＜ 0.01).The level of IL-10 and IL-17 in slight degree,middle degree and severe degree patients was significantly increased [IL-10:(33.486 ± 14.568)ng/L,(106.189 ± 13.583) and (123.875 ± 14.892) ng/L;IL-17:(68.209 ± 9.332),(129.856 ± 11.456),(208.165 ± 12.854) ng/L](P＜ 0.05).The level of IL-10 had positive correlation with IL-17 (r =0.79,P＜0.01).Conclusions IL-10 and IL-17 participate in the pathogenesis of acute gastritis and they have high correlation.IL-10 may restrain IL-17 cells and control the progress of inflammation.

AIM: To establish a method of determining the content of total saponin of Radix et Rhizoma Notoginseng in buccal tablets by HPLC. METHODS: Chromatographic conditions are as follows:Hypersil NH_2 column(4.6 mm?200 mm,5 ?m) as the stationary phase,acetonitrile-1% phosphate buffer solution(0-10 min,20:80;10-20 min,25:75;20-25 min,45:55;25-30 min,50:50) as the mobile phase,the velocity of flow is 1.0 mL/min,the temperature of coloum is 35(?C) and the detection wavelength is 203 nm. RESULTS: The HPLC method has good linearity in determining the total saponin of Radix et Rhizoma Notoginseng content,and we can detect four saponins at the same time,linear range,ginsenoside Rg1 0.093 75-6 ?g,ginsenoside Re 0.011 72-0.75 ?g,notoginsenoside R1 0.023 44-1.5 ?g and ginsenoside Rb1 0.140 6-9 ?g,the correlation coefficient r=0.999 9. CONCLUSION: The established method in this article is simple and convenient,with good reproductivity.We can detect four saponins in the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets at the same time by this method.It can be used for quality control of the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets.

Objective To observe the effect of intellectual activity on the cognitive function of the elderly.Methods The longi-tudinal follow-up study and the cross-sectional study were undertaken among physical examination people.The intellectual activity group (92 cases,more than 60 years old)often to take part in any one or more of the following activities for 5 years and above:pla-ying chess,playing the game of go,playing mahjong,playing cards,playing checkers,calligraphy,painting,reading,etc.The frequen-cy of intellectual activity was more than once per week at least.According to gender,age and educational level,92 cases were screened out as the control group and the control group was not to take part in above-mentioned intellectual activities or occasionally attend.The respondents had no baseline cognitive impairment.MoCA,MMSE,ADL and self-made questionnaire were adopted to conduct the evaluation.One year later when health check-up,the above-mentioned scales were used to evaluate again.The score changes were compared between the control group and experimental group.Results When enrolling,there was no significant differences in the MoCA scores,MMSE scores and ADL scores between the two groups.One year later,the comparison of the MMSE scores and ADL scores between the control group and experimental group had no significant difference (P>0.05).The Mo-CA scores manifested 2 cases (2.2%)of below the critical value of cognitive impairment in the experimental group and 6 cases (6.5%)in the control group,reaching the mild cognitive impairment(MCI)standards,the difference between the two groups showed the statistical significance (P<0.05).Conclusion The intellectual activity may be beneficial for the prevention of cognitive decline of the elderly and the MoCA scale is more suitable for screening MCI.

Juvenile idiopathic arthritis (JIA) is the most common chronic arthropathy in childhood. Immune and genetic factors take part in the development of JIA and influence its consequence. Studies have identified association between JIA and genes encoding the human leukocyte antigens (HLA) . In this article we discuss the principles behind genetic studies of complex traits like JIA, and comprehensively catalog HLA candidate gene associated with JIA to date, and review several validated associations. Studies indicate that the HLA-Ⅰ, Ⅱ gene and their products play an important role in JIA pathogenesis, clinical course, hormonal effect and prognostic judgment. Studies in different ethnic groups indicate the main relationship between JIA and HLA is concentrated upon A, DR and DQ loci, especially the HLA-Ⅱ gene and some haplotypes. The different type of JIA is always with different HLA susceptible locus and protective locus. Different race, different region and different social environment also affect the JIA's susceptible gene polymorphism. Finally we discuss the problems existed in the study of JIA susceptibility and HLA polymorphism.

Objective To determine the value of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in patients with stable chronic obstructive pulmonary disease (sCOPD). Methods From 2015 January to 2015 August, 101 patients with stable chronic obstructive pulmonary disease and 81 healthy controls were en-rolled. All subjects underwent pulmonary function test to record FEV1%pred and FEV1%FVC and their serum sTREM-1 levels were determined. Arterial blood gas analyses and COPD assessment tests were also conducted in stable COPD patients. Results Serum sTREM-1 levels were significantly higher in stable COPD patients than healthy controls (113.2 ± 31.5 pg/mL and 83.8 ± 17.9 pg/mL respectively, P=0.000). sTREM-1 levels were posi-tively correlated with CAT score (r=0.507, P=0.000), whereas negatively correlated with FEV1%pred and PaO2 (r = 0.507, P = 0.000; r = 0.439, P = 0.000). Conclusion sTREM-1 is a promising biomarker to evaluate sCOPD in the future.

The immunopathogenesis of IgA vasculitis and IgA nephropathy both demonstrate IgA deposition,and abnormal glycosylation of IgAl molecule is their major pathogenesis.Therefore,it is clinically controversial that they are actually one disease.The present text will delineate their similarities and differences from aspects of epidemiology,clinic,pathology,mechanism and prognosis.

Objective To investigate the changes and clinical significance of the platelet parameters in tumor patients before or after radiochemotherapy.Methods The platelet parameters(PLT,PCT,MPV,PDW)were detected in 65 cases of tumor patients before and after radiochemotherapy by the Sysmex XN-1000 automatic hemacytology analyzer.Then the detection results were com-pared with those in the control group.Results Compared with the control group,PLT and MPV before therapy in the tumor pa-tients were significantly increased(P <0.01),but PCT and PDW had no statistical differences between the two goups(P >0.05). PLT,PCT and MPV after radiochemotherapy in the tumor patients were significantly lower than those before treated(P <0.01 ), but no statistically significant difference in PDW was found(P >0.05).Conclusion The measuration of platelet parameters in the tumor patients with radiochemotherapy has certain clinical significance to observe the status of the bone marrow suppression and es-timate the state of illness.

ObjectiveTo study the effect community health education on the quality of life in chronic obstructive pulmonary disease (COPD) patients.Methods Three hundred and sixty patients with COPD in remission were set as the observation group, while another 212 COPD patients during the same period as the control group.The control group received conventional health education and the obseravation group received systematic,targeted health mode.The two groups were compared in respect of the quality of life.Results Before intervention,the two groups showed no significant differences in the total score on quality of life as well as its dimensions (P>0.05).After intervention,the study group was higher than the control group in the total score on quality of life as well as its dimensions (P<0.05).Conclusion The community health education is effective for improving the quality of life of COPD patients.

In recent years,it is a tendency to substitute acute kidney injury (AKI) foracute renal failure (ARF)in the aspect of international nephrology and emergency medicine.Compared with the past,the causes for AKI in children at present has been transferred from primary kidney disease to multi-factors,moreover,the morbidity and mortality of AKI is staying at a high level.From the perspective of epidemiology this paper briefly analyses the common cause,mortality and morbidity of AKI in children.