Objective To study helical CT manifestations of neck lymph node metastasis in thyroid carcinoma.Methods Forty-four patients of neck lymph node metastasis in thyroid carcinoma were performed helical CT scans and were analyzed retrospectively to compare with pathology and operation.CT manifestations mainly included:density,sector and calcification.Results On the one hand,CT manifestations had common character of neck lymph node metastasis;that was low-attenuant center and rim enhancement,on the other hand,CT manifestations showed:(1)thinness-sand and mottle calcification in the metastatic lymph node;(2)metastatic lymph node obvious enhancement.After enhance average density ranged from 28.00~50.54 HU to 62.85~145.78 HU,average density was near or more than 100 HU.Conclusion In metastatic lymph node of thyroid carcinoma,the findings of thinness-sand and mottle calcification suggest malignant tumor in thyroid focal,and metastatic lymph nodes were obviously enhanced;average density of lymph node after enhancement is near or more than 100 HU.

Objective To observe the efficacy of intra-articular (IA) blockade of TNF-α by 3 etanercept injections in patients with rheumatoid arthritis (RA).Methods Eighteen moderate activity RA patients with resistant knee synovitis underwent three monthly IA injection of etanercept (25mg).The primary outcomes were visual analogue scale of target knee general health (VAS-TKGH) and VAS target knee Pain Score,and we also collected diameter of target knee joint,VAS fatigue Score,Health Assessment Questionnaire (HAQ),the 28-joint based disease activity score (DAS28) and joint fluid volume,which were all assessed at baseline and every four weeks after IA injection.Results All those 18 patients completed the treatment with the average disease duration of was (8 4.7 ± 54.1) months.After each IA injection,VAS-TKGH was significantly improved than baseline (P =0.03,0.02,0.02).and VAS target knee pain score was also significantly improved than baseline (P =0.03,0.00,0.00).After 3rd IA injection,VAS-TKGH was further reduced compared with those after 1 st and 2nd IA injection (P =0.02,0.03) ; while,VAS target knee pain score was further reduced after 3rd IA injection (P =0.00).Knee joint diameter,VAS fatigue score,HAQ and DAS 28 were significantly lower after 1st IA injection than baseline (P =0.03,0.02,0.03).After 2nd IA injection,VAS fatigue score,HAQ,and DAS28 were significantly further improved compared to treatment once (P =0.00,0.02,0.02) ;after 3rd IA injection,HAQ and DAS28 were further improved compared to those after 2nd IA injection (P =0.01,0.02).Joint fluid volume was significantly decreased after 2nd IA injection (P =0.01).Conclusion The tailor approach of intra-articular injections of anti-TNF agent might benefit RA patients who had resistant synovitis,and the side effect was rare.However,the sample was small and further observation is needed.

Objective To investigate the effect of acceptance and implementation therapy on anxiety and depression in cancer patients'spouse. Methods The spouses of 50 hospitalized patients from January to June 2014 were assigned into the control group and the spouses of another 50 cases of hospitalized patients from July to December 2014 into the observation group . All the patients received routine care methods. The control group received general health education and the spouses in the observation group were managed with acceptance and implementation therapy, totally for 3 times. After the intervention, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the levels of anxiety and depressions in both groups. Results Before intervention, there were no differences in SAS and SDS scores between the groups (P>0.05). After intervention, the SAS scores in the observation group and the control group scores were (48.36 ± 6.28) and (55.11 ± 6.74), respectively, with statistically significant difference (t=7.530, P<0.05). The SDS scores of the observation group and control group were (50.03 ± 4.12) and (58.50 ± 4.63) respectively, with statistically significant differences (t=6.672, P<0.05). The SAS and SDS score of observation group were lower than those before intervention (t = 7.283,7.524, all P < 0.05). Conclusion The acceptance and implementation therapy can effectively alleviate the anxiety and depression in the spouses of those patients with cancer.

Objective: To analyze plasma levels of catestatin (CST) in patients with different blood pressure (BP) and metabolic status.
Methods: Our research included in 3 groups: Control group,n=60 subjects with normal BP from physical examination in our hospital; 131 patients with essential hypertension (EH) were divided into 2 groups: Isolated EH group,n=90 and MS (metabolic syndrome) group,n=41. Plasma levels of CST, norepinephrine (NE) were examined, the ratio of CST/NE was calculated, and those indexes were compared among different groups.
Results: Compared with Control group, plasma levels of CST and the ratios of CST/NE were decreased in Isolated EH and MS groups,P<0.05-0.01. As BP increasing, plasma levels of CST were gradually decreased; compared with Isolated EH group, plasma level of CST and CST/NE were reduced in MS group,P<0.05.
Conclusion: Plasma levels of CST and the ratio of CST/NE were obviously decreased in EH patients, CST was even lower in MS patients which implied that CST might be involved in the development of EH and MS.

Hormones ; pharmacology ; Humans ; Nephrotic Syndrome ; drug therapy ; Prednisone ; administration & dosage ; Recurrence

Alveolar Epithelial Cells ; metabolism ; pathology ; Animals ; Apoptosis ; physiology ; Cell Survival ; physiology ; Cells, Cultured ; Epithelial Cells ; cytology ; physiology ; Genes, bcl-2 ; genetics ; Genes, p53 ; genetics ; Oxidative Stress ; genetics ; Rats

Biomechanical Phenomena ; Humans ; Lumbosacral Region ; physiology ; Male ; Occupational Health ; Wood ; Workplace

Objective To study the hypoglycemic effect of polysaccharide from stigma maydis and to explore its therapeutic mechanism preliminarily.Method The diabetes mice models were induced by tetraoxypyrimidine.The concentration of blood sugar was determined by glucose oxidase test.The influence of the stigma maydis polysaccharide on glycometabolism and its repair effect on damaged glycometabolism organs of diabetic mice were observed respectively by content determination of glycogen and by the measurement of activities of relative enzymes(superoxyde dismutase and glutathione peroxidase).Results The stigma maydis polysaccharide could decrease the blood sugar,promote the synthesis of glycogen and repair the damaged glycometabolism organs of diabetic mice.Conclusion The stigma maydis polysaccharide exhibits a good therapeutic effect on diabetic mice,and has a good development prospect.

BACKGROUND: Nickel-chromium ceramic alloy with well anti-causticity has been widely used in clinic; however, it should be paid much attention to the toxic and side effects of the released nickel and glucinium ions. Therefore, studies about modifying alloy component, enhancing physical and chemical performance, and improving biocompatibility are hot topics recently. OBJECTIVE: To measure the in vitro cytotoxicity of self-made nickel-chromium ceramic alloy comparing with nickel-chromium alloy and pure titanium metal. DESIGN, TIME AND SETTING: A contrast observational experiment was performed at Central Laboratory of China Medical University from May to December 2006. MATERIALS: L-929 cells at logarithmic phase were used in this study. Self-made nickel-chromium ceramic alloy was provided by Metal Institute of Chinese Academy of Science, pure titanium was provided by Matsukaze Japan Co., Ltd., and nickel-chromium alloy was provided by Heraeus Kulzer Dental Co., Ltd. METHODS: L-929 cells were assigned into nickel-chromium ceramic alloy, pure titanium, nickel-chromium alloy, positive control, and negative control groups. The cells were cultured in 96-well culture plate. Every five wells were randomly selected from each group, and 12 wells were used for the duplication. Cell suspension (100 μL) at concentration of 1.0×108/L was added in each well. Leaching liquor (100 μL) was added in self-made nickel-chromium ceramic alloy, pure titanium alloy, and nickel-chromium alloy groups, respectively, lead leaching liquor (100 μL) was added in positive control group to make the final concentration at 50%, and RPMI 1640 culture solution (100 μL) was added in the negative control group. MAIN OUTCOME MEASURES: Absorbance was measured at day 1, 2, 3, 4 and 5 using MTT colorimetric assay to calculate relative growth rate. RESULTS: There were no significant differences in absorbance between three metal groups and negative control group (P > 0.05), but there were significant differences in absorbance between three metal groups and positive control group (P < 0.05 or P < 0.01). Cell growth rate was > 100% and cytotoxicity was grade 0 in the pure titanium group; while, cell growth rate ranged from 86.36% to 99.49% and cytotoxicity was grade 1 in both self-made nickel-chromium ceramic alloy and nickel-chromium alloy groups. At day 3 after culture, cytotoxicity was grade 2 in the positive control group. CONCLUSION: Self-made nickel-chromium ceramic alloy has a little cytotoxicity and requires for the clinical application.

The paper collects the network data from www.haodf.com to establish a model,conducts an empirical study on the factors influencing the selection of doctors in online medical websites,and puts forward the suggestions for the construction of online medical websits from 4 aspects of normalizing management,focusing on propaganda,highlighting online public praise,and expanding profit channels.