Objective To analyze and investigate the thyroid hormone levels in the patients with coronary heart disease(CHD) . Methods The levels of thyroid hormones were detected by the immunochemiluminescence method in 108 cases of CHD in the car‐diology department of our hospital and 50 healthy controls from July 2012 to October 2014 .The detection results of various indica‐tors were analyzed by using the SPSS19 .0 software and two independent samples t -test .Results In 108 cases of CHD ,11 cases were thyroid dysfunction ,including 3 cases of hyperthyroidism ,5 cases of hypothyroidism ,1 case of subclinical hyperthyroidism and 2 cases of subclinical hypothyroidism .The FT3 level in two CHD groups was significantly lower than that in the control group ,the difference was statistically significant (P< 0 .05) ,although the FT4 level was decreased somewhat ,but the difference compared with the control group was not statistically significant (P>0 .05);the FT3 level in the CHD heart failure group was lower than that in the CHD non-heart failure group ,the difference was statistically significant (P<0 .05) ,the difference in the FT4 level had no statistically significant difference (P> 0 .05);the TSH level in the CHD group was similar to the that in the control group ,the difference was not statistically significance (P>0 .05) .No difference in thyroid hormone levels was observed between male and fe‐male CHD patients (P>0 .05) .Conclusion Monitoring in the change of thyroid hormone levels in the patients with CHD can effec‐tively reflect the severity of illness and conduces to observe the clinical efficacy .

Some hormones and glucocorticoid in chronic strss feedback are demonstrated to have significant effects on cancer progression.Recently,as a typical neuropeptide,gastrin releasing peptide (GRP) could mediate chronic stress to promote carcinogenesis through four conceivable mechanisms,such as regulating circadian rhythms,suppressing immunity system,acting as a mitogenic effect and mediating cancer-related psychiatric disorders,et al.

Objective To study metabolism of glucose and lipidin patients with hyperandrogenism and analyze the risk of their cardiovascular disease.Methods Object of study:firstly,choosed 118 cases of women of reproductive age from April 2013 to July 2014.Then detected their serum Testosterone (T),Estradiol (E2),fasting plasma Glucose (FPG),fasting plasma insu-lin (FINS),triglycerides (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipopro-tein cholesterol (LDL-C),lipoprotein (a),body mass index (BMI).Finally,divided them into different groups and analyzed the results using SOSS19.0 software and two independent samples t-test statistical method.Results BMI,T,FPG,HOMA-IR and TG were significantly more higher (P <0.05)in the group of hyperandr-ogenism than in the group of normal con-trol.However,E2,TC,HDL-C,LDL-C and LP(a)had no significant difference (P >0.05)in statistics between the group of hyperandrogenism and the group of normal control.Hyperandr-ogenism group was divided into PCOS group and non-PCOS group according to etiology.In those two groups,BMI,T,E2,FPG,HOMA-IR,TG,TC,HDL-C,LDL-C and LP(a)had no significant difference in statistics (P >0.05).According to the definition of obesity adults in china,78 patients with hyperan-drogenism were divided into 2 group,one with BMI normal (BMI<24 kg/m2 )and the other group with overweight and obe-sity (BMI≥24 kg/m2 ).In group with overweight and obesity,BMI,T,FPG,HOMA-IR,TG,TC,LDL-C and LP (a)were significantly higher than the group with BMI normal (P <0.05),moreover,HDL-C was significantly lower than the group normal (P <0.05).E2 had no significant difference in statistics between the two groups (P >0.05).Conclusion Investiga-tion of the relation between hyp-erandrogenism and metabolism of glucose and lipid,can not only practically guide life style and drug therapy,but also prevent cardio-vascular disease.

The present study used the experimental patterns of Go/No Go and no motion contingent negative variation (CNV) task into the research in order to study whether the CNV can express the implication of expectation. Through comparing the CNV under different conditions, the data collected from experiment showed that the key to evoked CNV was close to the warning signal and command signal. Whether the command signal was related to the task would impact on the amplitude of the CNV. This characteristics responses to the subjects' expectation. On this basis, CNV can be used as the electrophysiological index for the reflection of expected value in the conditions of this experiment.
Anticipation, Psychological ; Brain Waves ; Contingent Negative Variation ; Humans

Child ; Female ; Humans ; Paraquat ; poisoning ; Poisoning ; therapy ; Young Adult

Currently,statins are one of the most important medications for the prevention and treatment of cardio-cerebrovascular diseases.In recent years,a large number of clinical studies and metaanalyses have confirmed that statins can effectively reduce the risks of the occurrence and recurrence of ischemic stroke.This article reviews the applications of statins in the primary prevention,acute treatment,and the secondary prevention of ischemic stroke.

Objective:To investigate the effects of deguelin on the viability and apoptosis of Neuro-2A ( N2A) cells. Methods:The cell viability of N2A cells with the density of 5 × 104 ·ml-1 on the time points of 6, 12, 24, 48 and 72 hours after 1 × 10 -8 mol ·L-1 deguelin treatment using CCK-8 kits was determined, and that on the time point of 48 hours after 0, 1 × 10 -11 , 1 × 10 -10 , 1 × 10 -9 , 1 × 10 -8 , 1 × 10 -7 , 1 × 10 -6 or 5 × 10 -4 mol·L-1 deguelin treatment was also detected. The activity of caspase 3 was deter-mined in N2A cells treated by 2 × 10 -8 mol·L-1 deguelin for 24 hours. Results:N2A cells with the density of 5 × 104 ·ml-1 reached the peak level in the growth curve 48 hours after the incubation in DMEM medium with 10% fetal bovine serum. The cell viability of N2A cells was decreased after the treatment of 1 × 10 -8 mol·L-1 deguelin for 24-72 hours in a time-dependant manner or after the treatment of 1 × 10 -8 ~1 × 10 -6 mol·L-1 deguelin for 48 hours in a dose-dependant manner (P<0. 05) with IC50 of 1. 6 × 10 -8 mol ·L-1 . The activity of caspase 3 was increased after the treatment of 2 × 10 -8 mol·L-1 deguelin for 24 hours, which was 5. 6-fold of that in the control group. Conclusion: Cell viability of N2A cells is inhibited by deguelin in a time- and dose-dependent manner, which may be related to the activity increase of caspase 3.

Objective To observe the effect of Jiaweibugan decoction on c-jun mRNA expression of sciatic nerve in experimental di-abetic rat and explore the preventive and therapeutic effects of Jiaweibugan decoction on peripheral neuropathy in experimental diabetic rats. Methods The diabetic rat model, was established by streptozotocin (STZ). The rots were killed on the 4th or 8th week from the beginning of treatment, and c-jun mRNA of sciatic nerve was detected by reverse-transcriptase polymerase chain reaction (RT-PCR). Serum SOD was determined by xanthine oxidase method. Results The results of RT-PCR showed that c-jun mRNA expression of the model group on the 4th or 8th week was higher than that of the normal control group (P <0.05) , while those in model rats treated by Jiaweibugan decoction were markedly lower than those in non-treated model rats(P <0.05). The results showed that SOD of the model group on the 4th or 8th week was lower than that of the normal control group (P < 0.05) , while those in model rats treated by Jiaweibugan decoction were markedly higher than those in non-treated model rats(P < 0.05). Conclusion Jiaweibugan decoction has a preventive and therapeutic effect on peripheral neuropathy in experimental diabetic rats.

Objective To observe the effect of jiaweibugan decoction on VEGF expression of sciatic nerve in experimental diabetic rat and explore the preventive and therapeutic effects of iiaweibugan decoction on peripheral neumpathy in~xperimental diabetic rats.Methotis The diabetic rat model was established by streptozotocin(STZ).The rats were killed on the 4th or 8th week from the beginning of treatment respectively,and VEGF mRNA of sciatic nerve was detected by reverse-transcriptase polymerase chain reaction(RT-PCR).Resuits The results of RT-PCR showed that VEGF expression ofthe model group and treated group on the4th or8th week WaS higherthan that of the normal control group(P＜0.05).Compared with the model group,VEGF expression in the diabetic rats treated byjiaweibugan decoction increased markedly at the end of4th week(P＜0.05),while decreaSed significantly at the end of8th week(P＜0.05).Conclusion Jiaweibugan decoction has a proventive and therapeutic effect on peripheral neumpathy in experimental diabetic rats.