Multiple myeloma (MM) is the second most common hematological malignancy.In the 56th American Society of Hematology (ASH) annual meeting,there are mainly five hot and key topics focusing on development of MM treatment,including when is the opportunity of transplant-eligible patients in the era of novel therapy? Should continuous therapy be the standard therapeutic approach in MM? What is a practical approach to relapsed MM? How should the recurrence/refractory MM patients be managed and treated? And what are the approved agents and novel agents?

Multiple myeloma (MM) is a genetically complex disease that is becoming more common in today' s aging population.In the 18th European Hematology Association (EHA) annual meeting,there were a number of key topics focusing on the development of MM from intraclonal heterogeneity,novel therapeutic agents,and relapse and refractory MM therapy,etc.

Multiple myeloma is the second most common hematological malignancy.In the 19th European Hematology Association (EHA) conference,there are a number of hot and key topics focused on developing of MM diagnosis criteria,response evaluation,treatment strategy for elderly and relapse/refractory myeloma patients,and maintenance therapy etc.

Objective To observe the effect of Xuebijing injection on organs injury in patients with acute paraquat poisoning.Methods Thirty patients with paraquat poisoning were randomly divided into two groups.The improvement of liver and kidney function,SaO2,rate of death were observed and compared between the two groups.Results The ABG,SaO2,GGT and Crea were all improved significantly in the treatment group than control group.At last,two patients gave up their treatment,nine cases were cured,four cases died in treatment group.One patient gave up treatment,four cases were cured,ten cases died in control group.The total effective rate of the treatment group and control group was 60.0％,26.7％,the difference was significant(x2 =4.75,P＜0.05).Conclusion Xuebijing injection has very good clinical effect in multiple organ failure of paraquat poisoning,it is worthy of clinic application.

Objective To explore the clinical effects of Xueshuantong injection in the treatment of acute cerebral infarction(ACI).Methods 70 patients with ACI were divided into Xueshuantong injection treatment group and Fufangdanshen control group,The two groups were all treated with routine way.The treatment group were treated with routine way and the Xueshuantong injection for 14 days,The two groups before and after evaluation for neural function defect scale was evaluated,and hemorheology indices were detected.Results The treatment group basic recovery rate was 25.0％,Significant progress rate was 37.5％,progress rate was 27.5％,overall response rate was 90.0％.The control group were 16.7％,30.0％,23.3 ％,70.0％,the difference was significant (x2 =4.534,P ＜ 0.05),the hemorrheologic indices of the treatment group after drug use are statistically significant differences,compared with before drug use(all P ＜ 0.05).Conclusion Xueshuantong injection in treatment of acute cerebral infarction is safe and effective.

Objective: To study the influence of titanium dioxide nanoparticle(TiO 2) on follicle development and oocyte maturation of rats using in vitro rat preantral follicle culture system, so as to know whether TiO 2 can cause female reproductive toxicity and provide evidences for evaluating its safety. Methods: Rat ovaries were mechanically dissected to obtain preantral follicles and the individual preantral follicle was cultured in 96-well plates. The study was divided into 5 groups: three 25 nm TiO 2 groups (12.5 μg/ml, 25 μg/ml and 50 μg/ml), one negative control group (treated with culture medium), and one micron TiO2 control group. Ten days after culture, the ovulation was induced and the follicle development and oocyte maturation were observed. Results: The survival rate of follicles, formation rate of antral follicles and release rate of cumulus-oocyte cell complexes (COCs) all decreased with the increase of 25 nm TiO2 (P<0.05). Compared with the negative control group, micron TiO2 group had no obvious changes in the follicle development and oocyte maturation. Compared with the two control groups, 25 nm TiO2 caused obvious morphological changes of follicles and obvious decrease in follicle survival and formation rate of antral follicles. 50 μg/ml 25 nm TiO2 reduced the number of mature oocytes. Conclusion: 25 nm TiO 2 at 25 μg/ml or above can inhibit rat follicle development and oocyte maturation in vitro, while the micron TiO2 at the same dose has no obvious influence on follicle development and oocyte maturation, suggesting different toxic properties between nmTiO2 and micron TiO2. Titanium dioxide nanoparticle may have female reproductive toxicity and should be given more attention.

OBJECTIVE: To optimize the extraction condition of volatile oil from five medicinal materials in Rutongxiaojie granules and to optimize the inclusion process of the extracted volatile oil. METHODS: The extraction condition was evaluated by orthogonal test with the recovery of volatile oil as indicator; and the inclusion condition was evaluated with the comprehensive scores of recovery ratio of inclusion compound, the content of volatile oil in inclusion compound and the utilization ratio of the volatile oil as criteria. RESULTS: The optimum extraction condition was established as follows: the medicinal materials were soaked in 10 times volume of water for 1hour and distilled for 9h by steam distillation. The optimum inclusion condition was as follows: the proportion of volatile oil to ?-CD was 1∶8; the inclusion temperature was 30℃ and including time was 20min. CONCLUSION: Both the extraction condition and the inclusion condition were reasonable and feasible.

Objective To provide references foroptimizing the structure of human resourcesby investigating human resource development and the current situation of allocation in the hospital .Methods Descriptive statistical a-nalysis and Spearman rank correlation analysis were conducted on the data of human resource in the hospital from 2004 to 2013 and the situation of personnel allocation in the hospital at the end of 2013 was emphatically analyzed by the statistical description.Results The development of the total human resource from 2004 to 2013was adapted to the hospital development , but the development of staff at each positionwas at unbalance .The nursingstaff wasin short . The educational background structure of all kinds of positions was reasonable , but thestructure of professional titleswas unreasonable , without developing into talents team .Moreover ,the non-permanently-contracted staff took up a lar-ger proportion .Conclusion Hospitals need to achieve comprehensive development of human resource by setting up scientific conception of talents ,to improve the quantity and quality of nursing staff by enhancing nursing staff construc -tion, to forming an reasonable talent team by balancing the structure of personnel quality , and to stabilize the hospital staff structure by attaching importance to the management of non -permanently contracted staff .

Objective To evaluate the effects of dopamine (DA) alone or DA plus norepinephrine (NE) on hemodynamics, tissue oxygenation, acid-base balance and renal function during orthotopic liver transplantation (OLT).Methods Thirty ASA IE or IV patients undergoing OLT were randomly divided into 2 groups of 15 patients each. In group A DA was continuously infused during operation. The initial infusion rate was 1-3 ?g?kg-1 ?min-1 . The rate was then adjusted to MAP between 60-80 mmHg. While in group B DA and NE were continuously infused. The initial infusion rate of DA was 1-3 (?g?kg-1?min-1 and that of NE 0.03 ?g?kg-1?min-1 . Both rates were adjusted to MAP between 60-80 mm Hg but the maximal DA infusion rate was 5 ?g?kg-1?min-1 . Anesthesia was induced with midazolam, propofol, fentanyl and vecuronium and maintained with isoflurane inhalation, continuous propofol infusion and intermittent i.v. boluses of fentanyl, midazolam and pipecuronium. Radial artery was cannulated and S-G catheter was placed via right internal jugular vein. Hemodynamic variables such as MAP, CVP, PAP, PCWP, SVRI, PVRI, blood gases, mixed venous blood O2 saturation (SvO2), blood lactate, Cr and BUN were measured and O2 delivery (DO2 ) and O2 consumption (VO2 ) were calculated and recorded after induction and before surgery (T1 baseline), 60 min after operation was started (T2), at 60 min anhepatic phase (T3) and 60 min neohepatic phase (T4 ) and at the end of operation ( T5). Results There were no significant differences between the two groups with respect to age, sex, body weight, duration of operation and types of surgery. MAP and HR were quite stable in both groups. CVP, MPAP, PCWP, cardiac output (CO) and CI were significantly decreased while SVR and SVRI were increased during anhepatic phase (T3 ) in both groups ( P

Objective To investigate the association of expressions of cyclooxygenase-2(COX-2),matrix metanoproteinases-9(MMp-9)and Ki67 with occurrence,infiltration and metastasis of gastric cancer.Methods Fifty-eight surgically obtained and pathologically performed cancerous tissues were collected between Jan.2003 and Dec.2005.Among them,37 were males and 21 were females with mean age of 58.2 years(ranged from 31 to 76 years).Fifty-eight paracancerous tissues(5-6 cm apart form the cancer)were taken as controls.The expressions of COX-2,MMP-9 and Ki67 in cancerous or paracancerous tissues were examined by immunohistochemistry.Results The expressions of COX-2 and MMP-9 in cancerous tissues(82.76%and 68.9%,respectively)were higher than those in controls(37.93%and 24.14%,respectively,P＜0.01).The expressions of COX-2 and MMP-9 were not associated with sex,age,location and size of gastric cancer(P＞0.05),but were correlated with the depth of lymph node infiltration.metastasis and TNM stage(P＜0.05).The expression of MMP-9 was also associated with the degree of differentiation of gastric cancer(P＜0.05).There was a correlation between COX-2 and MMp-9 expressions in gastric cancer tissues(P＜0.05,C=0.359).The expression of Ki67 in tissues with positive expressions of COX-2 and MMp-9 was higher than that in negative ones(P＜0.O 1).Conclusion The COX-2,MMP-9 and Ki67 play important roles in metastasis and infiltration,which promote occurrence and development of gastric cancer.