Gap junctions are membrane structures made of intercellular channels that allow directly exchange of material and information between adjacent cells. It is the structural basis of gap junctional intercellular communication. Gap junction is aberrant frequently in variety of cancers, which relatives with tumor genesis and metastasis. New anti-cancer drugs targeting gap junctions will be a new direction for tumor treatment.

In the past decades,more and more mutant genes that cause inherited retinal diseases have been found.Meanwhile,many naturally occurring animal models have also been found to show similar gene mutations and phenotypes as the human inherited retinal diseases,which have led to the development of a variety of therapeutic strategies for those traditionally incurable inherited diseases.These models include rod degeneration (rd) mice,such as rd1 model,rd10 model and nmf137.To compare the efficacy of these strategies,this article briefly reviews the recent progress in the treatment of the mouse models with mutations in the subunit of rod phosphodiesterase (Pde6b)gene by pharmaceutical,stem cell and gene therapy in order to find a more effective treatment for retinal degeneration.

On the basis of status and technical characteristics of rehabilitation training instrument in China, this article summarized theconcept and significance of reliability-based design, introduced the technical target of rehabilitation training instruments and the procedureof building a reliability model. The future prospect of applying reliability-based design to rehabilitation training instruments is also discussed.

Humans ; Multiple Myeloma ; complications ; Neuritis ; etiology ; prevention & control ; therapy ; Renal Insufficiency ; etiology ; prevention & control ; therapy

Objective To make a method to determine trace iron (FeⅢ)in human hair. Methods Based on the coloured reaction between XO and Fe(Ⅲ)in the medium of HAc-NaAc(pH=3.2)with the presence of OP, FeⅢ was determined by spetrophotometry. Results It was found that when pH=3.2 and in the presence of OP, iron(Ⅲ) reacted with XO to form a stationary complex. The maximum absorption wave of Fe(Ⅲ)-XO was 570 nm, as OP was added, it moved to 590 nm, and the sensitivity was increased obviously when the molar absorptivity of the complex reached 3.67?105 L/(mol?cm) from 3.04?104 L/(mol?cm), the linear range for the content of Fe(Ⅲ)was 0.0～0.8 ?g/ml(0.0～20.0 ?g/25 ml), the regression equation of calibration graph was A=0.00236+0.542c(?g/25 ml)with a correlation coefficient of 0.997 6, detection limit was 6.09?10-6 g/L, RSD=0.97% and rate of recovery was 96%-99%. Conclusion The method can be used for the determination of trace iron(Ⅲ)in human hair samples.

Objective To compare the clinical effect of different administration methods of carboprost tromethamine for the treatment of scar uterus with cesarean resection.Methods 120 cases of puerpera with uterine scar uterus and postpartum hemorrhage tendency were selected,and the history of cesarean section was once and more than once.According to the digital table,they were randomly divided into observation group(60 cases)and control group(60 cases),the observation group was divided into single carboprost tromethamine administration group(30 cases) and sub carboprost tromethamine administration group (30 cases).The clinical efficacy of the three groups were compared.Results In the observation group,the incidence rates of postpartum hemorrhage(13.33%,10.00%)were significantly lower than 28.33% in the control group(χ2 =10.844,6.822,all P <0.05).The incidence of postpartum hemorrhage of the single carboprost tromethamine administration group and sub carboprost tromethamine administration group(13.33% vs.10.00%)showed no statistically significant difference(χ2 =0.538,P >0.05).24h postpartum hemorrhage in the observation group[(263.11 ±137.04)mL,(359.98 ±212.35)mL]were significantly lower than those of the control group[(461.52 ±127.67)mL](t =5.795,2.247,all P <0.05).24h postpartum hemorrhage of the sub carboprost tromethamine administration group[(263.11 ±137.04)mL]was significantly less than that of the single carboprost tromethamine administration group[(359.98 ±212.35)mL,t =2.097,P <0.05].There was no statistically significant difference in the adverse reactions among the three groups(P >0.05).Conclusion Carbo-prost tromethamine can significantly reduce the bleeding rate of uterine scar again after cesarean section,sub carbo-prost tromethamine administration can significantly reduce the amount of bleeding in postoperative 24h,it is worth popularizing in clinical.

Objective To study the application effect of PDCA management mode in the teaching process of practice nurses in spine surgery to reduce the occurrence of nursing errors. Methods A total of 35 practice nurses in spine surgery from March 2014 to March 2015 received the routine teaching mode were set as control group, and 35 practice nurses from April 2015 to April 2016 implemented PDCA management mode were set as intervention group. The occurrence rate of nursing adverse events in two years was observed, and the interns for clinical teaching evaluation model of quality and satisfaction and the intern examination results were summarized. Results The incidence of nursing adverse events was 22.86% (8/35) in control group, and 2.86% (1/35) in intervention group, the difference was statistically significant (χ2= 17.85, P = 0.00). The intern teacher for clinical teaching content arrangement, teaching attitude, detail guidance and skills training indicators evaluation score were (15.46±1.03), (14.18±1.06), (14.61±1.11), (13.30±1.07) points in control group, and (18.26±1.00), (18.48±0.51), (19.43±0.21), (19.16± 0.28) points in intervention group, the differences were statistically significant (t = 11.54- 31.34, P <0.01). The interns given theory and skills examination results were (80.15±1.61), (85.16±1.02) points in control group, and (93.10±2.01), (91.06±2.03) points in intervention group, the difference was statistically significant (t = 29.75, 15.36, all P = 0.00). The clinical teaching satisfaction was 57.14% (20/35) in control group, and 80.00% (28/35) in intervention group, the difference was statistically significant (χ2=12.12, P=0.00). Conclusions PDCA management model applied to clinical practice in department of orthopedics teaching process, can effectively improve the intern theory knowledge and skills to master the ability, most of the interns examination results are more optimistic, and for this kind of management pattern for the process of teaching evaluation of higher satisfaction, the teachers care under the guidance of intern nursing mistake, nursing adverse events is low, this method is worthy of promotion.

The development of modern medicine calls for the return of medical humanistic spirits,and it is in-evitable to strengthen medical humanistic education.This paper compared the current situation of medical humanis-tic education between Chinese and American medical colleges from the construction of teaching staff,the establish-ment of curriculum system,and teaching method and evaluation.It put forward some suggestions for the dilemma of the development of medical humanistic education according to the actual medical education in our country,and ex-plored the reform paths of medical humanistic education in our country.

As most of medical school has been incorporating with comprehensive university,it is of great importance for university leaders and managers to make out how to take full advantage of the opportunity for incorporating with university and make full use of medical education resource to improve the benefit of capital operation.

Objective to analyze the major problems existing in laboratory medicine and put forward the improvement measures. Methods The dissertations of 69 graduates in Laboratory medicine major in 2008 were analyzed. Results A total of 62 teachers guided 69 students to complete their thesis,and the dissertation score was normal with outstanding dissertations accounting for 4.38% and good dissertations accounting for 65.21%;and medium accounting for 30.43%. Conclusion: The quality of graduation thesis should be promoted from the start of each aspect of the thesis,and quality control should be implemented in the whole process.