1.The use of multi-slice spiral CT angiography for hemoptysis
Qiuzhen XU ; Shenghong JU ; Gang DENG ; Min WU ; Gaojun TENG
Chinese Journal of Radiology 2011;45(5):445-448
Objective To evaluate the nse of CT angiography in the diagnosis of hemoptysis and guiding the treatment of it with 64-slice spiral CT.Methods Twenty-two patients with repeated and massive hemoptysis underwent chest CT angiography.Results The blood supply of hemoptysis was nonbronchial systemic arteries in 3 patients,single or multiple bronchial arteries in 15 patients,mixed arteries of nonbronchial systemic and bronchial arteries in 3 patients and abnormal systemic arteries in 1 patient.Conclusion With 64-slice spiral CT,CT angiography provided useful information for the treatment of hemoptysis by guiding bronchial arterial embolization.
3.Research status and translational application of new extraction techniques of traditional Chinese medicine.
Sai-Jun WANG ; Zhen-Feng WU ; Ming YANG ; Ya-Qi WANG ; Fang WANG ; Gang KE ; Ju-Min HUANG
China Journal of Chinese Materia Medica 2014;39(8):1360-1367
Extraction is the critical link during pharmaceutical process of traditional Chinese medicine (TCM), which is directly related to the quality of drugs. So the key to technology upgrading of pharmaceutical equipment in Chinese materia medica enterprise is the development of new extraction techniques, which concerns the modernization of TCM. In this paper, fundamentals, traits, and development status of new extraction technologies were firstly introduced, including ultrasound extraction, microwave extraction, super fluid extraction, semi-bionic extraction method, enzymatic treatment extraction, continuous countercurrent extraction, vacuum extraction. Then information of projects supported by the National Natural Science Foundation of China was analyzed in order to recognize the assistance and research results of new extraction techniques. The patents authorized by the State Intellectual Property Office were also summarized for the purpose of understanding the achievement transformation. The information about extraction equipments was collected and screened to acquire the characteristics and market situation. The results showed that there are still problems about new extraction technologies, such as weak basic study, hard transformation of achievements, and the disconnection between research study and practical application. It is necessary to discuss the approaches and methods for accelerating the transformation of fundamental research, which will provide references for the long-term development of new extraction techniques of TCM.
Chemistry, Pharmaceutical
;
economics
;
methods
;
trends
;
China
;
Drugs, Chinese Herbal
;
analysis
;
economics
;
isolation & purification
;
Medicine, Chinese Traditional
;
economics
;
trends
;
Plants, Medicinal
;
chemistry
;
Translational Medical Research
;
trends
4.Case-control study on ultra-early application with intermittent pneumatic compression to prevent postoperative deep venous thrombosis of intertrochanteric femoral fracture in elderly patients.
Ju LI ; Gang WU ; Wei-Feng JI ; Pei-Jian TONG
China Journal of Orthopaedics and Traumatology 2012;25(1):32-34
OBJECTIVETo evaluate the clinical effects of ultra-early application with intermittent pneumatic compression (IPC) in preventing postoperative lower limbs deep venous thrombosis (DVT) of intertrochanteric fractures in elder patients.
METHODSFrom May 2008 to May 2010, 80 patients with intertrochanteric fractures were randomly divided into ultra-early group and postoperative group. In ultra-early group, there were 21 males and 19 females, ranging in age from 67 to 86 years with an average of (76.4 +/- 13.27) years; in postoperative group, there were 26 males and 14 females, ranging in age from 68 to 89 years with an average age (75.8 +/- 12.71) years. IPC was respectively used at the 3rd day before operation (ultra-early group) and postoperative that day (postoperative group). Serum D-dimer of all the patients were measured at the 3rd day before operation and at the 3rd, 7th,14th days after operation. Lower limbs DVT were observed by ultrasound at the 3rd, 14th days postoperatively. Perioperative bleeding volume of patients were compared between two groups.
RESULTSThere was no statistical difference in the serum D-dimer concentration and lower limbs DVT between two groups at the 3rd day before operation (P > 0.05). There was no statistical difference in perioperative bleeding volume between two groups (P > 0.05). In ultra-early group, Serum D-dimer concentration at the 3rd, 7th days after operation was respectively (351.00 +/- 104.34), (412.31 +/- 106.95) microg/ml; and in postoperative group, the item was respective (419.34 +/- 145.38), (509.16 +/- 146.05) microg/ml; serum D-dimer concentration in ultra-early group was lower than postoperative group (P < 0.05). There was no significant differences in serum D-dimer concentration at the 14th day after operation between two groups (P > 0.05). Incidence of DVT in postoperative group was 22.5%, which was higher than that of ultra-early group at the 14th day after operation (P < 0.05). There was no significant differences at the 3rd day after operation between two groups (P > 0.05).
CONCLUSIONCompared with postoperative application with IPC, ultra-early application with IPC could reduce the level of serum-dimer and the incidence of DVT without increase perioperative blood of intertrochanteric fracture in elder patients.
Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Fibrin Fibrinogen Degradation Products ; analysis ; Hip Fractures ; surgery ; Humans ; Intermittent Pneumatic Compression Devices ; Male ; Postoperative Complications ; prevention & control ; Time Factors ; Venous Thrombosis ; prevention & control
5.Analysis of maternal mortality in Sichuan province from 2015 to 2016
Fangyin WU ; Tianjin ZHOU ; Ziling ZHAO ; Gang ZHANG ; Weixin LIU ; Ju ZHANG ; Jingtao LIU
Chongqing Medicine 2017;46(32):4556-4557,4560
Objective To analyze the maternal mortality in Sichuan province from 2015 to 2016 for the purpose of providing reference for the department of health and family planning,medical and health care institutions to take measures to reduce maternal mortality.Methods The death assessment panel reviewed 163 cases of maternal mortality data in Sichuan province from 2015 to 2016 in accordance with "twelve grid method" of the World Health Organization(WHO).The findings were descriptively analyzed.Results Provincial level had completed 163 cases of maternal death review,and it suggested that obstetric hemorrhage,pregnancy induced hypertension,venous thrombosis and pulmonary embolism,heart disease,amniotic fluid embolism were the five leading causes of maternal mortality in Sichuan province.Among the 163 evaluated death cases,death could be avoided in 124 cases(76.07%) and death was unavoidable in 39 cases(23.93 %).According to the first influencing factors,among 124 cases of avoidable deaths in medical records,the death of 67 cases(54.03%) was caused by medical staff knowledge and skills,ranking first,including the county(37.90%) and township(5.65%);the death of 57 cases was caused by the personal family,accounting for 45.97%.Conclusion It's important for the reduction of maternal mortality in Sichuan province to strengthen standardized management of high-risk pregnant women,ensure the timely supply of blood resources in remote areas,and enhance the training of emergency medical knowledge for obstetric medical personnel.
6.Diagnostic and prognostic value of preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 in colorectal cancer
Hua YANG ; Gang XIAO ; ju Guo WU
Chinese Journal of Current Advances in General Surgery 2017;20(7):518-521
Objective:To evaluate the the diagnostic and prognostic value of preoperative serum carcinoembryonic antigen(pre-CEA) and carbohydrate antigen 19-9(pre-CA19-9) in colorectal cancer.Methods:382 colorectal carcinoma patients were analyzed retrospectively,who come from Beijing Hospital between June 2008 and June 2011.The clinical and histopathologic data such as age,sex,location of tumor,depth of tumor(T),lymph node metastasis(N),stage,and preoperative serum levels of CEA and CA 19-9 and prognosis were obtained.Results:The positive rate of pre-CEA,pre-CA19-9 and joint detection were 42.9%,18.6% and 48.4% respectively.The elevation of pre-CEA and pre-CA19-9 were significantly associated with depth of tumor,lymph node metastasis,perineural invasion,and stage (P<0.05).Univariate analysis showed that the predictors of survival were the elevation of pre-CEA and pre-CA19-9 (P<0.05).Multivariate analysis showed that the elevation of pre-CA19-9 and TNM were independent prognosis factors (P<0.05).Conclusion:The pre-CEA and pre-CA19-9 have diagnostic and prognostic value in patients with colorectal cancer.Joint detection can increase the positive rate.Pre-CA19-9 was independent prognosis factors.
7.Effect of precursor of brain-derived neurotrophic factor on hippocampal neuron survival and its mechanism.
Hui WANG ; Dan CHEN ; Xiao-qiong WU ; Ju-fang HUANG ; Xue-gang LUO
Journal of Central South University(Medical Sciences) 2007;32(5):800-805
OBJECTIVE:
To explore the effect of precursor of brain-derived neurotrophic factor (proBDNF) on cultured hippocampal neuron and its intracellular mechanism.
METHODS:
The hippocampal neurons were dissociated from E18 rats and cultured in neurobasal medium, and then the cells were treated with proBDNF, preBDNF(propeptide of proBDNF) and proBDNF antiserum,respectively. Thirty minutes, 1 hour or 48 hours later, the cells were stained with Nissl solution, and the immunocytochemistry methods of ELK-p (Ets domain protein), ErK2(extracellular signal regulated kinase) and c-fos were performed.
RESULTS:
The expressions of ELK-p, ErK and c-fos were significantly upregulated in the cultured hippocampal neurons after they were treated with proBDNF protein,and the immuno-positive staining was also obvious in some nuclei. While the endogenous proBDNF was neutralized by proBDNF antiserum treatment, the expressions of ELK-p, ErK and c-fos were downregulated and many cells showed swelling and vasoculation. The immunoreactivity in preBDNF treated cells was similar to that in normal cultured cells.
CONCLUSION
proBDNF plays an important role in sustaining the hippocampal neuron survival through upregulating the ELK and ErK pathways.
Animals
;
Brain-Derived Neurotrophic Factor
;
pharmacology
;
Cell Survival
;
drug effects
;
Cells, Cultured
;
Hippocampus
;
cytology
;
Mitogen-Activated Protein Kinase 1
;
metabolism
;
Neurons
;
cytology
;
metabolism
;
Protein Precursors
;
pharmacology
;
Proto-Oncogene Proteins c-ets
;
metabolism
;
Proto-Oncogene Proteins c-fos
;
metabolism
;
Rats
;
Signal Transduction
8.Treatment of deep partial thickness burns by a single dressing of porcine acellular dermal matrix.
Xiang-sheng FENG ; Yin-gen PAN ; Jia-ju TAN ; Qiu-he WU ; Rui SHEN ; Shu-bin RUAN ; Xiao-dong CHEN ; Feng-gang ZHANG ; Ze-peng LIN ; Yong-jun DU
Chinese Journal of Surgery 2006;44(7):467-470
OBJECTIVETo explore the effect of one dressing of porcine acellular dermal matrix on deep partial thickness burns.
METHODSFrom January 1997 to January 2004, sixty-seven cases of deep partial thickness total burned surface area (TBSA) from 50% to 90% burn wound were treated by a single dressing of porcine acellular dermal matrix (the porcine acellular dermal matrix group). Ten cases of deep partial thickness burned patients with the same TBSA treated by exposure method served as the exposure method group. The healing time of the wound was observed. The patients were followed up for 3 months to 2 years, and the scar proliferation was observed.
RESULTSThe deep partial-thickness wound would be healed without dressing change in the porcine acellular dermal matrix group, and the average healing time was (12.2 +/- 2.6) days. The average healing time of the exposure method group was (27.4 +/- 3.5) days. Follow up of the patients within 3 months to 2 years showed that scar proliferation in the porcine acellular dermal matrix group was much less than that in the exposure method group, even no scar proliferation was observed in some patients.
CONCLUSIONWithout tangential excision, autografting and dressing change, a single dressing of porcine acellular dermal matrix on deep partial thickness burn wound could shorten the healing time and inhibit scar proliferation.
Animals ; Biological Dressings ; Burns ; pathology ; therapy ; Cicatrix ; prevention & control ; Female ; Follow-Up Studies ; Humans ; Male ; Swine ; Treatment Outcome ; Wound Healing
9.Comparison of efficacy of pegylated interferon alfa-2a or interferon alfa-2b combination therapy with nucleus(t)ide analogues in HBeAg positive chronic hepatitis B patients.
Shu-qiang WANG ; Kai-ju XU ; Jia-zhen WU ; Xiao-shu LIU ; Ting-ting LUO ; Ren-guo YANG ; Xiao-xia GENG ; Ren-gang HUANG ; Jian-mei LIN ; Nan JIANG
Chinese Journal of Hepatology 2011;19(10):785-786
Adult
;
Antiviral Agents
;
administration & dosage
;
therapeutic use
;
Drug Therapy, Combination
;
Female
;
Hepatitis B e Antigens
;
Hepatitis B, Chronic
;
drug therapy
;
immunology
;
Humans
;
Interferon-alpha
;
administration & dosage
;
therapeutic use
;
Male
;
Nucleotides
;
administration & dosage
;
therapeutic use
;
Polyethylene Glycols
;
administration & dosage
;
therapeutic use
;
Recombinant Proteins
;
administration & dosage
;
therapeutic use
;
Treatment Outcome
;
Young Adult
10.The incidence of dementia among elderly people in Xi' an, China.
Qiu-min QU ; Jin QIAO ; Jian-feng HAN ; Jian-bo YANG ; Feng GUO ; Guo-gang LUO ; Hua YANG ; Hong-mei CAO ; Xi-chi JU ; Cheng-bin WU
Chinese Journal of Epidemiology 2005;26(7):529-532
OBJECTIVETo explore the incidence of dementia among elderly people in Xi'an and its related risk factors.
METHODSSubjects that had been studied on the prevalence of dementia were follow-up, and the incidence of dementia, Alzheimer disease (AD) , and vascular dementia (VD) were counted by person-years. The clinical diagnosis on dementia,AD and VD were based upon the 3rd Edition of Diagnostic and Statistical of Manual of Mental Disorder, Revised version (DSM-III-R) and NINCDS-ADRDA criteria.
RESULTS2197 subjects of non-dementia being identified in 1998, were re-surveyed in 2001. Out of them, 47 new cases of dementia including 37 cases of AD and 8 cases of VD were identified, with an annual incidence rates of dementia, AD and VD as 0.68%, 0.54% and 0.12% among those of 55 years and over and 0.89%, 0.69% and 0.17% in 65 years and over, respectively. Analysis from single factor logistic regression showed that age and education but not gender were closely related to the occurrence of AD. On the contrary, age, hypertension and stroke were closely related to the occurrence of VD.
CONCLUSIONThe incidence of dementia in the "Xi' an cohort" was similar to that being reported from other countries. AD and VD were an age-related diseases but education seemed to have had great protective effect while lack of formal education served as risk factor to AD.
Age Distribution ; Aged ; Aged, 80 and over ; China ; epidemiology ; Dementia ; classification ; epidemiology ; Educational Status ; Female ; Follow-Up Studies ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Sex Distribution