1.Simultaneous Elevation of Epidermal Growth Factor Receptor and Transforming Growth Factor - alpha in the Serum of Colorectal Cancer Patients.
Kang Sup SHIM ; Kwang Ho KIM ; Ju Young SEOH ; Eung Bum PARK
Journal of the Korean Cancer Association 1998;30(3):536-543
No abstract available.
Colorectal Neoplasms*
;
Epidermal Growth Factor*
;
Humans
;
Receptor, Epidermal Growth Factor*
2.Clinical obsevation of pleural effusion.
Choon Sup KIM ; Kee Joong JU ; Chang Hwan LEE ; Sung Min PARK ; Young Woong SHIM ; Kap Young SONG
Tuberculosis and Respiratory Diseases 1993;40(5):584-594
No abstract available.
Pleural Effusion*
3.A Case of Portal and Splenic Vein Thrombosis Developed by Complication of Histoacryl Injection Therapy in Gastric Varix.
Sung Won CHO ; Chan Sup SHIM ; Moon Sung LEE ; Jun Sung LEE ; Myung Lyel LEE ; Jae Hark JU
Korean Journal of Gastrointestinal Endoscopy 1994;14(4):437-441
Liquid tissue adheisve, Histoacryl (n-butyl-2-cyanoacrylate) has been used for the treatment of gastric variceal bleeding. The techniques are as follows: 0.5cc Histoacryl mixed with Lipiodol per each injection are used. 3 to 4 injections are usually required for large variceal convolutes under the fluoroscopic visualization after the injection of Histoacryl. Complications of sclerotherapy with Histoacryl are bleeding, perforation, stenosis and embolism depending on the concentration and amount used, as well as the intensity of the treatment. Here we describe a case report developing portal and splenic vein thrombosis as a side effect after Histoacryl injection therapy for the treatment of gastric varix bleeding, A 59-year-old male patient with liver cirrhosis was admitted due to acute gastric varix bleeding. The control of gastrie variceal bleeding was achieved by several injections of 0.7c mixture of 0.5cc histoacryl and 0,8cc Lipiodol. However, simple X-ray and ultrasonography revealed the elements of Histoacryl-lipiodol mixture in the portal and splenic vein.
Constriction, Pathologic
;
Embolism
;
Enbucrilate*
;
Esophageal and Gastric Varices*
;
Ethiodized Oil
;
Hemorrhage
;
Humans
;
Liver Cirrhosis
;
Male
;
Middle Aged
;
Sclerotherapy
;
Splenic Vein*
;
Thrombosis*
;
Ultrasonography
4.A Case of Esophageal Perforation during Endoscopic Variceal Ligation.
Chan Sup SHIM ; Joon Seong LEE ; Moon Sung LEE ; Hong Soo KIM ; Chan Wook PARK ; Kwang Hwe LEE ; Hyung Joo PARK ; Sun Ju KIM
Korean Journal of Gastrointestinal Endoscopy 1995;15(2):223-233
Endoscopic variceal ligation(EVL) was developed to provide a safer alternative than injection sclerotherapy for treatment of bleeding esophageal varices. EVL adds a new indication that will significantly increase the use of overtubes. overtube itself may have a role in predisposing to esophageal perforation but only one report has been published regarding an esophageal perforation related to the placement of an overtube. Recently, we experienced a case of esophageal perforation caused by overtube placement during endoscopic variceal ligation. So we report this case with review of relevant literatures.
Esophageal and Gastric Varices
;
Esophageal Perforation*
;
Hemorrhage
;
Ligation*
;
Sclerotherapy
5.Tonsillar Squamous Cell Carcinoma Associated with Dermatomyositis: The First 2 Cases in Korea.
Sung Wan KIM ; Ju Sup SHIM ; Young Gyu EUN ; Kee Hwan KWON
Yonsei Medical Journal 2010;51(4):605-608
Dermatomyositis (DM) is an autoimmune disorder with idiopathic myopathy and characteristic skin manifestations that one often accompanied by an internal malignancy. The association between dermatomyositis and malignancy has been reported several times, although tonsillar carcinoma is extremely rare not only in far eastern populations but also in caucasian populations. We report two cases of Korean patients with dermatomyositis associated with tonsillar carcinoma.
6.A Case of Malignant Fibrous Histiocytoma on Nasal Dorsum.
Ju Sup SHIM ; Sung Wan KIM ; Chang Il CHA ; Joong Saeng CHO
Korean Journal of Otolaryngology - Head and Neck Surgery 2005;48(11):1398-1401
Soft tissue sarcoma of the head and neck is a rare and heterogenous group of malignant tumors. Especially, adult soft tissue sarcomas occur rarely in nasal cavity and paranasal sinus. They are, when poorly differentiated, termed as pleomorphic sarcoma, spindle cell sarcoma, or malignant fibrous histiocytoma (MFH) like tumor. The main stay of the treatment of adult soft tissue sarcomas is surgical resection with negative margin. Tumor grade, tumor size and extension of local infiltration are recognized prognostic factors, but classification of histologic type appears to have less prognostic significance. In case of uncontrolled locoregional disease, it often results in death due to intracranial extension. We report a case of a 68-year-old female with locoregional high grade pleomorphic sarcoma in the nasal cavity. This tumor was managed by wide local excision of tumor with negative margin.
Adult
;
Aged
;
Classification
;
Female
;
Head
;
Histiocytoma, Malignant Fibrous*
;
Humans
;
Nasal Cavity
;
Neck
;
Sarcoma
7.The Short Stature in Children with Hypertrophy of Adenoid and Tonsil or Allergic Rhinitis.
Ju Sup SHIM ; Sung Wan KIM ; Hee Seok CHOI ; Myung Gu KIM ; Joong Saeng CHO
Korean Journal of Otolaryngology - Head and Neck Surgery 2006;49(4):390-394
BACKGROUND AND OBJECTIVES: There is little data to indicate that hypertrophy of adenoid and tonsil may cause short stature. However, there is no data relating short stature to allergic rhinitis in the Korean population. The aim of this study was to investigate the effect of hypertrophy of adenoid and tonsil and allergic rhinitis on children with short stature. SUBJECTS AND METHOD: One hundred and ninety-one children were included in the disease group, which consisted of three groups, allergic rhinitis only (n=83), hypertrophy of adenoid and tonsil only (n=67), and combintorial of allergic rhinitis and hypertrophy of adenoid and tonsil (n=41). There were 174 pediatric patients in the control group. Growth hormone levels, thyroid function and both wrist X-rays were checked on the children with short stature in order to exclude other chief medical problems causing short stature. For the purpose of evaluating the relationship between short stature and clinical factors, allergy parameters, eosinophil partition rate and total IgE levels were checked in the allergic rhinitis group, and the size of the adenoid and tonsil were checked in the adenoid and tonsil hypertrophy group. The relationship between the incidence of short stature and above clinical factors was evaluated. RESULTS: The incidence of short stature was significantly higher in each disease group than in the control. However, there was no statistically significant differences between each disease group. The above clinical factors were not associated with short stature. CONCLUSION: Hypertrophy in adenoid and tonsil and allergic rhinitis might be an independent cause of short stature.
Adenoids*
;
Body Height
;
Child*
;
Eosinophils
;
Growth Hormone
;
Humans
;
Hypersensitivity
;
Hypertrophy*
;
Immunoglobulin E
;
Incidence
;
Palatine Tonsil*
;
Rhinitis*
;
Thyroid Gland
;
Wrist
8.Plasminogen Activator Inhibitor Type 1 (PAI-1) A15T Gene Polymorphism Is Associated with Prognosis in Patients with EGFR Mutation Positive Pulmonary Adenocarcinoma.
Ju Eun LIM ; Moo Suk PARK ; Eun Young KIM ; Ji Ye JUNG ; Young Ae KANG ; Young Sam KIM ; Se Kyu KIM ; Hyo Sup SHIM ; Byoung Chul CHO ; Joon CHANG
Tuberculosis and Respiratory Diseases 2013;75(4):140-149
BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1), an important regulator of plasminogen activator system which controls degradation of extracellular membrane and progression of tumor cells, and PAI-1 gene polymorphic variants have been known as the prognostic biomarkers of non-small cell lung cancer patients. Recently, experimental in vitro study revealed that transforming growth factor-beta1 initiated PAI-1 transcription through epithelial growth factor receptor (EGFR) signaling pathway. However, there is little clinical evidence on the association between PAI-1 A15T gene polymorphism and prognosis of Korean population with pulmonary adenocarcinoma and the influence of activating mutation of EGFR kinase domain. METHODS: We retrospectively reviewed the medical records of 171 patients who were diagnosed with pulmonary adenocarcinoma and undergone EGFR mutation analysis from 1995 through 2009. RESULTS: In all patients with pulmonary adenocarcinoma, there was no significant association between PAI-1 A15T polymorphic variants and prognosis for overall survival. However, further subgroup analysis showed that the group with AG/AA genotype had a shorter 3-year survival time than the group with GG genotype in patients with EGFR mutant-type pulmonary adenocarcinoma (mean survival time, 24.9 months vs. 32.5 months, respectively; p=0.015). In multivariate analysis of 3-year survival for patients with pulmonary adenocarcinoma harboring mutant-type EGFR, the AG/AA genotype carriers had poorer prognosis than the GG genotype carriers (hazard ratio, 7.729; 95% confidence interval, 1.414-42.250; p=0.018). CONCLUSION: According to our study of Korean population with pulmonary adenocarcinoma, AG/AA genotype of PAI-1 A15T would be a significant predictor of poor short-term survival in patients with pulmonary adenocarcinoma harboring mutant-type EGFR.
Adenocarcinoma*
;
Biomarkers
;
Carcinoma, Non-Small-Cell Lung
;
Genotype
;
Humans
;
Medical Records
;
Membranes
;
Multivariate Analysis
;
Phosphotransferases
;
Plasminogen Activator Inhibitor 1
;
Plasminogen Activators*
;
Plasminogen*
;
Polymorphism, Single Nucleotide
;
Prognosis*
;
Receptor, Epidermal Growth Factor
;
Retrospective Studies
9.A Case of Biliary Mucinous Cystadenocarcinoma.
Chan Sup SHIM ; Dong Wha LEE ; Young Sik SONG ; Joon Seong LEE ; Moon Sung LEE ; Hong Soo KIM ; So Young JIN ; Sun Ju KIM ; Young Chang LEE ; Won Young SHIN ; Kwang Hee LEE ; Moon Su LEE
Korean Journal of Gastrointestinal Endoscopy 1995;15(2):267-273
Biliary cystadenoma and cystadenocarcinoma are rare tumors which have a good prognosis after complete surgical removal. Correct pre-operative diagnosis depends on the imaging characteristics of the tumors. Computed tomography, Ultrasono-graphy, angiography and cholangiogram are useful diagnostic procedure in biliary cystic tumor but definite diagnosis cannot be made without histologic diagnosis. Before the surgery, cholangioscopy is necessary for deciding operation field. The prognosis of the biliary cystic tumor seems to be much better than that of other solid hepatic tumors. If there is no evidence of metastasis, complete resection of these tumors is, therefore, necessary for these possibly curable disease. Recently, we experienced a 60-year-old woman complained of jaundice and generalized itching sensation, which was diagnosed as biliary mucinous cystadenocarcinoma. We decided operation field by cholangioscopy, and performed left hepatic lobectomy and T-tube choledochojejunostomy. So, we report this case with a review of relevant literature.
Angiography
;
Choledochostomy
;
Cystadenocarcinoma
;
Cystadenocarcinoma, Mucinous*
;
Cystadenoma
;
Diagnosis
;
Female
;
Humans
;
Jaundice
;
Middle Aged
;
Mucins*
;
Neoplasm Metastasis
;
Prognosis
;
Pruritus
;
Sensation
10.4 Cases of Mucosal Bridges in the Esophagus.
Chan Sup SHIM ; Moon Sung LEE ; Joo Young CHO ; Dong Ha CHUN ; Jae Il KIM ; In Hwan YU ; Gyeu Hyuk KIM ; Ju Il PARK ; Jung Kun EO ; Seong Chan LA ; Soo Kyung KIM ; Sae Hwan HAN
Korean Journal of Gastrointestinal Endoscopy 1996;16(6):969-975
Mucosal bridge, endoscopically observed, is a cord-like mucosal connection across the lumen. The bridge is very elastic and stretches easily, unlike granulation tissue. Mucosal bridges of the esophagus have been occasionally described in various circumstances, particularly in congenital or acquired origin as the inflammatory diseases. The occurrence of mucosal bridges due to inflammatory process may arise anywhere from the esophagus to the colon. It has been more frequently reported in the colon than in the esophagus, stomach, and duodenum. We experienced four cases of esophageal mucosal bridges and three of them were accompanied by esophageal diverticulum. We report these cases with a review of relevant literatures.
Colon
;
Diverticulum
;
Diverticulum, Esophageal
;
Duodenum
;
Esophagus*
;
Granulation Tissue
;
Stomach