Purpose: This study aimed to examine the influence of nursing organizational culture, nursing workplace spirituality, and nurses’ perceived health status on quality of nursing work life according to nursing clinical ladder at a tertiary hospital. Methods: Participants were nurses working at a tertiary hospital in D city, and a total of 352 participants were recruited according to four stages of clinical experience: novice stage (below 1 year), advanced beginner stage (2~3 years), competent stage (4~6 years), and proficiency stage (above 7 years). Data were collected from February 7-February 16, and analyzed using descriptive statistics, one-way ANOVA, Scheffe test, and Multiple regression. Results: There was statistically significant correlation between innovation-oriented nursing organizational culture, nursing workplace spirituality, nurses’ perceived health status and quality of nursing work life. In all clinical ladder stages, nursing work spirituality and nurses’ perceived health status were factors influencing the quality of nursing work life; innovation-oriented nursing organizational culture was an influencing factor in the novice, advanced beginner, and competent stage, but not the proficient stage. Conclusion To improve the quality of nursing work life, it is necessary to develop and apply practical programs that reflect nurses’ characteristics at each clinical ladder stage.

Purpose: This study aimed to examine the influence of nursing organizational culture, nursing workplace spirituality, and nurses’ perceived health status on quality of nursing work life according to nursing clinical ladder at a tertiary hospital. Methods: Participants were nurses working at a tertiary hospital in D city, and a total of 352 participants were recruited according to four stages of clinical experience: novice stage (below 1 year), advanced beginner stage (2~3 years), competent stage (4~6 years), and proficiency stage (above 7 years). Data were collected from February 7-February 16, and analyzed using descriptive statistics, one-way ANOVA, Scheffe test, and Multiple regression. Results: There was statistically significant correlation between innovation-oriented nursing organizational culture, nursing workplace spirituality, nurses’ perceived health status and quality of nursing work life. In all clinical ladder stages, nursing work spirituality and nurses’ perceived health status were factors influencing the quality of nursing work life; innovation-oriented nursing organizational culture was an influencing factor in the novice, advanced beginner, and competent stage, but not the proficient stage. Conclusion To improve the quality of nursing work life, it is necessary to develop and apply practical programs that reflect nurses’ characteristics at each clinical ladder stage.

Purpose: This study aimed to examine the influence of nursing organizational culture, nursing workplace spirituality, and nurses’ perceived health status on quality of nursing work life according to nursing clinical ladder at a tertiary hospital. Methods: Participants were nurses working at a tertiary hospital in D city, and a total of 352 participants were recruited according to four stages of clinical experience: novice stage (below 1 year), advanced beginner stage (2~3 years), competent stage (4~6 years), and proficiency stage (above 7 years). Data were collected from February 7-February 16, and analyzed using descriptive statistics, one-way ANOVA, Scheffe test, and Multiple regression. Results: There was statistically significant correlation between innovation-oriented nursing organizational culture, nursing workplace spirituality, nurses’ perceived health status and quality of nursing work life. In all clinical ladder stages, nursing work spirituality and nurses’ perceived health status were factors influencing the quality of nursing work life; innovation-oriented nursing organizational culture was an influencing factor in the novice, advanced beginner, and competent stage, but not the proficient stage. Conclusion To improve the quality of nursing work life, it is necessary to develop and apply practical programs that reflect nurses’ characteristics at each clinical ladder stage.

Purpose: This study aimed to examine the influence of nursing organizational culture, nursing workplace spirituality, and nurses’ perceived health status on quality of nursing work life according to nursing clinical ladder at a tertiary hospital. Methods: Participants were nurses working at a tertiary hospital in D city, and a total of 352 participants were recruited according to four stages of clinical experience: novice stage (below 1 year), advanced beginner stage (2~3 years), competent stage (4~6 years), and proficiency stage (above 7 years). Data were collected from February 7-February 16, and analyzed using descriptive statistics, one-way ANOVA, Scheffe test, and Multiple regression. Results: There was statistically significant correlation between innovation-oriented nursing organizational culture, nursing workplace spirituality, nurses’ perceived health status and quality of nursing work life. In all clinical ladder stages, nursing work spirituality and nurses’ perceived health status were factors influencing the quality of nursing work life; innovation-oriented nursing organizational culture was an influencing factor in the novice, advanced beginner, and competent stage, but not the proficient stage. Conclusion To improve the quality of nursing work life, it is necessary to develop and apply practical programs that reflect nurses’ characteristics at each clinical ladder stage.

Background/Aims: Prokinetic agents and neuromodulators are among the treatment options for functional dyspepsia (FD), but their comparative efficacy is unclear. We aimed to compare the efficacy of mosapride controlled-release (CR) and nortriptyline in patients with FD after 4 weeks of treatment. Methods: Participants with FD were randomly assigned (1:1) to receive mosapride CR (mosapride CR 15 mg and nortriptyline placebo) or nortriptyline (mosapride CR placebo and nortriptyline 10 mg) in double-placebo, double-blinded, randomized controlled, parallel clinical study. The primary endpoint was defined as the proportion of patients with overall dyspepsia improvement after 4 weeks treatment. The secondary endpoints were changes in individual symptom scores, anxiety, depression, and quality of life. Results: One hundred nine participants were recruited and assessed for eligibility, and 54 in the mosapride CR group and 50 in the nortriptyline group were included in the modified intention-to-treat protocol. The rate of overall dyspepsia improvement was similar between groups (53.7% vs 54.0%, P = 0.976). There was no difference in the efficacy of mosapride CR and nortriptyline in a subgroup analysis by FD subtype (59.3% vs 52.5% in postprandial distress syndrome, P = 0.615; 44.4% vs 40.0% in epigastric pain syndrome, P = > 0.999; 50.0% vs 59.1% in overlap, P = 0.565; respectively). Both treatments significantly improved anxiety, depression, and quality of life from baseline. Conclusion Mosapride CR and nortriptyline showed similar efficacy in patients with FD regardless of the subtype. Both treatments could be equally helpful for improving quality of life and psychological well-being while also relieving dyspepsia.

Purpose: This study aimed to investigate the perceptions of precocious puberty and elucidate the distinct characteristics of each type of perception related to precocious puberty among school-aged children who had undergone treatment for the condition. Methods: This study applied the Q methodology to identify and classify the perceptions of precocious puberty among school-aged children who had undergone treatment for the condition. The analysis involved 34 questions from the Q sample and data from 35 individuals in the P sample, using the PC-QUANL Program for analysis. Results: The perceptions of precocious puberty among school-aged children who had undergone precocious puberty treatment were classified into the following four types: "shyness - passive self-management," "resentment - suppression," "anxiety - fear," and "adaptation - acceptance." Conclusion This study investigated the experiences and perceptions of children who have undergone treatment for precocious puberty. Through the identification of four types of perceptions, we can see that there is a need to develop an intervention program for nursing that is tailored to the specific type of precocious puberty.

Background: This study was conducted to examine the effect of adverse childhood experiences on depressive symptoms in university students and to verify whether positive psychological resources act as a protective factor for depression. Methods: Data from 1,317 young adults aged 18-29 years who took part in the university-based cross-sectional survey were analyzed. All participants completed self-report questionnaires that included demographic variables, the Adverse Childhood Experience (ACE) Scale, the Patient Health Questionnaire-9, and the Positive Resources Test. Results: The incidence of depression was 33.3% and was higher in women than in men. Based on the 10 ACE categories, 32.7% of the students reported one or more adverse childhood experiences, and 14.4% reported two or more forms of adverse childhood experiences. Students with depressive symptoms were likely to report more traumatic experiences in childhood and fewer positive psychological resources than those without depressive symptoms. Hierarchical regression analysis indicated that positive psychological resources moderated the relationship between adverse childhood experiences and depression. Conclusion Based on these results, professionals should consider identifying adverse childhood experiences early and provide active mental health service support, including positive psychological and social resources for individuals who have adverse experiences during childhood.

Purpose: This study aimed to identify the changes in psychological distress and the quality of life in patients with esophageal cancer from pre-surgery to 3 months after surgery. Methods: We enrolled 49 patients scheduled to undergo esophageal surgery at a tertiary hospital in Seoul, South Korea. Patients’ psychological distress and quality of life were assessed using the Korean scales, such as the Hospital Anxiety and Depression Scale (HADS), European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30), and an esophageal cancer-specific questionnaire (QLQ-OES18) at pre-surgery, 1 month, and 3 months post-surgery. Results: Moderate-to-severe anxiety was reported in 12.2% of patients at the pre-surgery evaluation, 57.1% of patients at 1 month post-surgery, and 8.2% at 3 months post-surgery. Moderate-to-severe depression was reported in 12.2% of patients at the pre-surgery evaluation, 63.3% at 1 month post-surgery, and 16.3% of patients at 3 months post-surgery. Clinically significant, moderate changes (10~20 points) in physical functioning, insomnia, nausea and vomiting, and dyspnea (per EORTC QLQ-C30) and dysphagia and taste problems (per QLQ-OES18) were reported from pre-surgery to 1 month post-surgery. Conclusion One month after esophageal cancer surgery, patients demonstrated severe psychological distress and worsening quality of life. Nursing intervention is needed to relieve psychological distress and improve the quality of life in patients with esophageal cancer in the 1-month early recovery period.

Coronavirus disease 2019 (COVID-19) is associated with a systemic inflammatory response that activates coagulation in symptomatic patients. In addition, a rare form of thrombosis has been reported in people who received the COVID-19 vaccine, most of whom were women younger than 50 years of age. Considering that hormonal contraceptive methods widely used by women of childbearing age increase the risk of thrombosis, the development of guidelines for the use of hormonal contraceptives in the era of the COVID-19 pandemic is necessary. In this context, the Korean Society of Contraception and Reproductive Health provides guidelines for issues regarding contraception and reproductive health during the pandemic.

Objective: The endothelial inflammatory response plays an important role in atherogenesis by inducing nuclear factor (NF)κB-dependent cell adhesion molecule expression and monocyte recruitment. Here, we screened for natural ligands and investigated the ability of shinjulactone A to inhibit interleukin-1β (IL-1β)-induced endothelial inflammatory signaling. Methods: The natural compound library included 880 single compounds isolated from medicinal plants by the Korean Medicinal Material Bank. Primary endothelial cells were pretreated with single compounds before stimulation with IL-1β to induce endothelial inflammation. Endothelial inflammation was measured by assaying NFκB activation and monocyte adhesion. The endothelial-mesenchymal transition (EndMT) was evaluated using cell type-specific marker protein expression and morphology. Results: Shinjulactone A was identified as an efficient blocker of IL-1β -induced NFκB activation, with a half-maximal inhibitory concentration of approximately 1 µM, and monocyte recruitment in endothelial cells. However, it did not affect lipopolysaccharideinduced NFκB activation in macrophages. Compared to Bay 11-782, a well-known NFκB inhibitor that shows considerable cytotoxicity during long-term treatment, shinjulactone A did not affect endothelial cell viability. Furthermore, it also significantly inhibited the EndMT, which is known to promote atherosclerosis and plaque instability. Conclusion We suggest that shinjulactone A may be an effective and safe drug candidate for atherosclerosis because it targets and inhibits both endothelial inflammation and the EndMT, without impairing NFκB-dependent innate immunity in macrophages.