1.Pharmacometabolomics: Current Applications and Future Perspectives.
Translational and Clinical Pharmacology 2014;22(1):8-10
Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical technologies, metabolomics enables the assessment of comprehensive metabolic profiles that are affected by both genotype and environmental factors. Recently, attention has been focused on the concept of pharmacometabolomics, an emerging field that is derived from metabolomics. Pharmacometabolomics is focused on the use of individual metabolic signatures for the prediction and evaluation of drug efficacy and safety, eventually accelerating clinical pharmacology toward personalized drug therapy.
Biochemical Processes
;
Biomarkers
;
Diagnosis
;
Drug Therapy
;
Genotype
;
Humans
;
Precision Medicine
;
Metabolome
;
Metabolomics
;
Pharmacology, Clinical
2.Corrigendum: Characterizing affinity epitopes between prion protein and beta-amyloid using an epitope mapping immunoassay.
Mino KANG ; Su Yeon KIM ; Seong Soo A AN ; Young Ran JU
Experimental & Molecular Medicine 2014;46(5):e96-
Due to an author error the National Research Foundation of Korea Grant Number was incorrectly listed in the original online publication of this article.
3.Predictors of neurologic handicap in hypoxic ischemic encephalopathy.
Seung Tae KIM ; Gui Ran KIM ; Byung Hak LIM ; Sang Geel LEE ; Im Ju KANG
Journal of the Korean Pediatric Society 1991;34(4):473-479
No abstract available.
Hypoxia-Ischemia, Brain*
4.The Effect of Milk on the Bioavailability of 6-mercaptopurine.
Sun Kyu PARK ; Ran Ju KIM ; Pyoung Han HWANG ; Soo Chul CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1994;37(12):1732-1737
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoblastic leukemia. The bioavailibility, clinical efficacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at differnt times in same patient. there are many factors affecting the bioavailibility of 6-MP. The most notably factor being that concomitantly administered drugs and foods might contribute to a decrease in the bioavailibity of this drug. In our sociocultural environment milk is a major constituent of child's foods. Cow's milk contains a high concentration of xanthine oxidase, which could potentially transform 6-TM into 6-thioxanthine (6-TX) and 6-thiouric acid (6-TUA) which have no more therapeutic effects. In this study, we evaluated the effect of various milk products on the bioavailability of 6-MP. Incubation at 37degrees C for 30 min raw or pasteurized milk resulted in transformation of a large quantity of clinically relevant concentration of 6-MP into 6-TUA. The concomitant adminstration of folic acid and allopurinol has markedly inhibitory effect on the 6-MP destroying activity of milk at clinically relevant concentrations. These observations may help to optimize modalities of administration of 6-MP for the treartment of patients with childhood leukemia.
6-Mercaptopurine*
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Allopurinol
;
Biological Availability*
;
Child
;
Complement Factor B
;
Folic Acid
;
Humans
;
Leukemia
;
Milk*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
Xanthine Oxidase
5.Change of Electrolytes after Transfusion of A.C.D. Stored Blood Warmed to 36 degrees C.
Kyung Ran JU ; Chang Keun AHN ; Woo Kyung KIM
Korean Journal of Anesthesiology 1979;12(1):34-37
In the operation room of S.N.U.H., 10 patients were transfused with A,C.D. stored blood after warming to 36 degrees C by using a blood warmer. Observed changes of Na+, Cl-, K+ and. Ca++ were as follows. 1) Before warming, the electrolytes of A.C.D. stored blood were Na+ 148. 2 mEq/1, Cl-; 117. 0 mEq/1 and K+; 8. 4 mEq/l. After warming to 36C, these were significantly reduced(P <0. 05) and became 144. 6mEq/1, 112. 4mEg/1 and 68. 13mEq/1 respectively. 2) There was a tendency to increasing of K+ cencentration in proportion to storage duration. 3) In the case of calcium, pre-warmed concentration of calcium was 4. 09 mEq/1 and there was no significant change after warming(P>0.05).
Calcium
;
Electrolytes*
;
Humans
6.A Case of Steven-Johnson Syndroe Associated with Cholestatic Hepatitis.
Tae Hee PARK ; Ran Ju KIM ; Byoung Geun LEE ; Soo Chul CHO ; Dae Yeol LEE
Journal of the Korean Pediatric Society 1994;37(7):1016-1019
A 12-year-old boy developed cholestatic hepatitis with Steven-Johnson syndrome following the use of amoxicillin. The skin lesion and general condition were improved over 2 weeks, but jaundice was gradually aggrevated. We performed liver biopsy, on 30th hospital day, which showed cholestatic hepatitis. The patient improved gradually and liver function was normalized 5 months later.
Amoxicillin
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Biopsy
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Child
;
Hepatitis*
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Humans
;
Jaundice
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Liver
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Male
;
Skin
7.Long-Term Binocularity in Accommodative Esotropia.
Journal of the Korean Ophthalmological Society 2015;56(5):759-763
PURPOSE: To find clinical factors related to the long-term outcome of binocularity in accommodative esotropia. METHODS: Forty-nine patients with accommodative esotropia who were followed over 5 years after successful optical alignment within 8 prism diopters of orthophoria at near and distance with glasses including bifocals were included. The patients who had stereo acuity better than 50 seconds/arc and central fusion without suppression scotoma at the final visit were divided into the bifoveal fusion group and the others were divided into the peripheral fusion group. Clinical factors were analyzed between the two groups (Chi-square test, student t-test). RESULTS: Of the 49 patients, 15 patients were included in the bifoveal fusion group and 34 patients were included in peripheral fusion group. Mean follow-up was 88.9 +/- 25.4 months. Clinical factors that were significantly related to the bifoveal fusion group were older age of onset, shorter duration of misalignment, intermittent esotropia at the initial visit and after initial optical correction, smaller residual deviations at distance after initial optical correction and at the final visit, and lesser amblyopia. CONCLUSIONS: To obtain better levels of long-term binocularity, optical correction should be done as early as possible, before the presence of constant eye misalignment or amblyopia, and the residual esodeviations after optical correction should be kept as small as possible.
Age of Onset
;
Amblyopia
;
Esotropia*
;
Eyeglasses
;
Follow-Up Studies
;
Glass
;
Humans
;
Scotoma
;
Telescopes*
8.A Case of Ulcerative Colitis.
Jong Sung EUM ; Hwa Jin BYUN ; Ai Ran KIM ; Jae Sun JUNG ; Hee Ju KIM ; Seung Il AHN
Journal of the Korean Pediatric Society 1989;32(1):109-115
No abstract available.
Colitis, Ulcerative*
;
Ulcer*
9.Detection of antigen of RSV and clinical considerations on epinephrine response in wheezy infancy.
Gui Ran KIM ; Seoung Tae KIM ; Hyang Suk HYUN ; Sang Geel LEE ; Im Ju KANG ; Sei Yun JUNG
Journal of the Korean Pediatric Society 1991;34(3):388-397
No abstract available.
Epinephrine*
10.Detection of antigen of RSV and clinical considerations on epinephrine response in wheezy infancy.
Gui Ran KIM ; Seoung Tae KIM ; Hyang Suk HYUN ; Sang Geel LEE ; Im Ju KANG ; Sei Yun JUNG
Journal of the Korean Pediatric Society 1991;34(3):388-397
No abstract available.
Epinephrine*