1.Two Cases of the Salts Losing Congenital Adrenal Hyperplasia.
Journal of the Korean Pediatric Society 1981;24(11):1092-1099
No abstract available.
Adrenal Hyperplasia, Congenital*
;
Salts*
2.Clinical Observation on 16 Squamous Cell Carcinomas in Orthopedics
The Journal of the Korean Orthopaedic Association 1977;12(1):55-60
Squamous cell carcinoma has occasionally been encountered in orthopedic practice as a complication of chronic osteomyelitis, burn scar and other lesions. The possible occurrence of this secondary change impose difficulty in the diagnosis and management of chronic orthopedic diseases. During 11 years from 1966 to 1976, 16 cases of squamous cell carcinoma were confirmed by histopathological examination and the results of clinical observation on them are summarized here. l. Of 16 patients, men were 15 and woman one. Their average age was 51.3 years 2. The primary lesions in which this malignancy developed were osteomyelitis (5 cases), and scar (5 cases), and scar after extensive laceration (2 cases). In one case no primary lesion was present. 3. Average duration of symptomatology of the primary lesion was 35.4 years in osteomyelitis and 31.2 yeary in burnscar. 4. Location of the lesion was in lower extremity in 15 cases, eight of which were in the leg. 5. Methods of treatment undertaken were; amputation (10 cases), chemotherapy (2 cases), chemotherapy and irradation (1 case). In three no treatment was done because of refusal. 6. The follow-up study was possible in five of them. Of four cases amputated, one was well alive for two years after ablation with no evidence of metastasis, the others two showed spread, to inguinal nodes in one and ribs in the other, after two years and the fourth died of unknown disease after two years. The fifth died, after initial remission with chemotherpy and irradation, of lung cancer after two years.
Amputation
;
Burns
;
Carcinoma, Squamous Cell
;
Cicatrix
;
Diagnosis
;
Drug Therapy
;
Epithelial Cells
;
Female
;
Follow-Up Studies
;
Humans
;
Lacerations
;
Leg
;
Lower Extremity
;
Lung Neoplasms
;
Male
;
Neoplasm Metastasis
;
Orthopedics
;
Osteomyelitis
;
Ribs
4.A Clinical Observation on Meningitis in Infancy and Childhiid.
Jin Kyu PARK ; Eui Hyung KIM ; Tae Ju HWANG
Journal of the Korean Pediatric Society 1984;27(6):554-562
No abstract available.
Meningitis*
5.The Effects of Physeal Injury upon Angular Correction and Growth of Rat's Tibia
Myung Sang MOON ; Dal Ju KWON ; Hyung Min KIM
The Journal of the Korean Orthopaedic Association 1977;12(2):213-223
No abstract available in English.
Tibia
6.Osteogenic Sarcoma as Second Malignant Neoplasm After Treatment of Retinoblastoma.
Ja Young KIM ; Moon Whan LEE ; Ju Hyung KIM ; Pyoung Han HWANG ; Jung Soo KIM
Journal of the Korean Pediatric Society 1990;33(12):1735-1740
No abstract available.
Osteosarcoma*
;
Retinoblastoma*
7.A case of thrombotic thrombocytopenic purpura achieved complete remission with plasmapheresis and prednisolone.
Ju Young KIM ; Kyoo Hyung LEE ; Kyoung Ah KIM ; Hyun Sook CHI ; Sang Hee KIM
Korean Journal of Hematology 1993;28(2):429-434
No abstract available.
Plasmapheresis*
;
Prednisolone*
;
Purpura, Thrombotic Thrombocytopenic*
8.Gene Expression Profiling of 6-MP (6-mercaptopurine) in Liver.
Hyung Lae KIM ; Han Na KIM ; Eun Ju LEE
Genomics & Informatics 2006;4(1):16-22
The KFDA (Korea Food & Drug Administration) has performed a collaborative toxicogenomics project since 2003. Its aim is to construct a toxicology database of 12 compounds administered to mice at initial phase. We chose 6-MP (6-mercaptopurine) which has been used in the treatment of childhood leukemia. It was administered at low (0.224 mg/kg) and at high (2.24 mg/kg) dose (5 mice per group) intraperitonealy to the postnatal 6 weeks mice, then the serum and liver were collected at the indicated time (6, 24 and 72 h) after scarification. Serum biochemical markers for liver toxicity were measured and histopathologic studies also were carried out. The gene expression profiling was carried out by using Applied Biosystems 1700 Full Genome Expression Mouse. By self-organization maps (SOM), we identified groups with unique gene expression patterns, some of them are supposed to be related to 6-MP induced toxicity, including lipid metabolism abnormality, inflammatory response, oxidative stress, ATP depletion and cell death. The potential toxic effects appearing as gene expression changes are dependent of the time of 6-MP but independent of the dosage of it. This study would contribute to establishment of international database as well as national one about hepatotoxicity.
Adenosine Triphosphate
;
Animals
;
Cell Death
;
Gene Expression Profiling*
;
Gene Expression*
;
Genome
;
Leukemia
;
Lipid Metabolism
;
Liver*
;
Mice
;
Microarray Analysis
;
Oxidative Stress
;
Toxicogenetics
;
Toxicology
;
Biomarkers
9.Normal Values of rNeonatal Periumbilical Skin Length.
Young Pyo CHANG ; Hyung Suk LIM ; Hye Won PARK ; Woong Huen KIM ; Hee Ju KIM
Journal of the Korean Pediatric Society 1994;37(7):924-927
Malformations of umbilicus are a feature of many dysmorphic syndromes and the measurement of periumbilical skin length should be considered as the basic step in the description of the umbilical malformations. So, we measured the periumbilical skin length in the 103 normal neonates and obtained the following results. 1) The means (+SD) of the periumbilical skin length were the 11.7mm (+3.0) in the cranial site and the 8.2mm (+2.5) in the caudal site, and the cranial length was 3.5mm longer than the caudal length. 2) No difference was observed between the male and female groups in the periumbilical skin length. 3) Age was the only statistically significant variable associated with the periumbilical skin length and it was observed that the periumbilical skin length decreased according to the advance of age (hour).
Female
;
Humans
;
Infant, Newborn
;
Male
;
Reference Values*
;
Skin*
;
Umbilicus
10.Two Cases of Hand-Schuller-Christian Disease in Monozygotic Twin.
Pyoun Han HWANG ; Ju Hyung KIM ; In Soo CHOI ; Jung Soo KIM
Journal of the Korean Pediatric Society 1985;28(1):85-89
No abstract available.
Humans
;
Twins, Monozygotic*