No abstract available.
Asthma* ; Theophylline*

"Capsaicin, the pungent principle of hot peppers, is a neurotoxin that depletes primary sensory neurons of neuropeptides like tachykinin. The objectives of these experiment was to examine the effects of capsaicin on Salmonel/a typhimurium-induced production of cytokines such as TNF-a, IL-1B, IL-6, IL-10 and IL-12 and on production of nitric oxide in peritoneal macrophages. In addition, the effects of capsaicin on survival rates of S. typhimurium-infected mice and on nuclear transcription factor (NF-kB) activation were also investigated. Mice were pretreated with a single s.c. injection of 100 ug of capsaicin and were infected i.v. with S. typhimurium (5xO5/mouse) in 0.2 ml volume after capsaicin pretreatment. The serum cytokine levels were measured 30, 60, 120, 180 and 240 min after Salmonella infection, using ELISA kits. The activation of NF-B was also examined by gel shift assay in spleens, thymuses and brains of mice that had been pretreated with a single s.c. injection of 100 ug of capsaicin. It was found that Sa/mone/la infection induced the production of TNF-a, IL-1B, IL-6, IL-10 and IL-12, but capsaicin pretreatment inhibited the production of TNF-a, IL-1B, IL-10 and IL-12, but enhanced IL-6 production 120 min after Salmonella infection. Interestingly, the capsaicin pretreatment inhibited the activation of NF-kB in spleens and thymuses. There were no differences in the numbers of bacteria in livers, brains, spleens, kidneys and lungs between capsaicin- pretreated mice and the control animals in applied experimental conditions. Suprisingly, however, capsaicin pretreatment increased both the survival rates of Sa/mone//a-infected mice and production of nitric oxide by peritoneal macrophages compared with capsaicin-untreated control mice. Taken together, these results indicate that the capsaicin-sensitive primary sensory neurons may play an important modulatory role in the production of cytokine, nitric oxide and NF-B activation and the pathogenesis of salmonellosis."
Animals ; Bacteria ; Brain ; Capsaicin* ; Cytokines* ; Enzyme-Linked Immunosorbent Assay ; Interleukin-10 ; Interleukin-12 ; Interleukin-6 ; Kidney ; Liver ; Lung ; Macrophages, Peritoneal ; Mice ; Neuropeptides ; NF-kappa B* ; Nitric Oxide* ; Salmonella Infections* ; Salmonella typhimurium ; Salmonella* ; Sensory Receptor Cells ; Spleen ; Survival Rate ; Tachykinins ; Thymus Gland ; Transcription Factors

No abstract available.
Brain* ; Child* ; Humans ; Seizures*

PURPOSE: Atopic findings may be associated with severity of pneumonia in 2009 pandemic influenza A (H1N1) infection, which could suggest a possible association between atopic findings and the severity of viral infections. Thus, we studied association between atopic findings and severity of disease in children with H1N1 influenza infection. METHODS: A retrospective study was performed in 74 children admitted in a single tertiary institute and confirmed as H1N1 patients by reverse transcriptase (RT) - polymerase chain reaction (PCR). They were divided into 2 groups according to the severity of pneumonia. We evaluated whether the atopic finding is risk factor between the two groups. RESULTS: Children with severe pneumonia had higher percentages of serum eosinophilia (88% vs 40%, P<0.001), asthma (65% vs 35%, P=0.011), allergic rhinitis (71% vs 40%, P=0.009), and IgE level (P=0.007). We found positive correlations between aeroallergen sensitizations and severity of pneumonia (82% vs 53%, P=0.007). CONCLUSION: Among patients with H1N1 pneumonia, asthma and atopic findings are risk factors for severity of pneumonia.
Asthma ; Child ; Eosinophilia ; Humans ; Immunoglobulin E ; Influenza, Human ; Pandemics ; Pneumonia ; Polymerase Chain Reaction ; Retrospective Studies ; Rhinitis ; Rhinitis, Allergic, Perennial ; Risk Factors ; RNA-Directed DNA Polymerase

No abstract available.
Humans ; Twins*

PURPOSE: This study was conducted to identify and define the concept of job-esteem of the hospital nurses. METHODS: Data were analyzed using the hybrid model, introduced by Schwartz-Barcott and Kim. Data were obtained from a relevant literature review and also from the in-depth interviews of twelve nurses with clinical experience of more than 3 years. RESULTS: The concept of job-esteem of the hospital nurses was finally analyzed with 5 attributes and 13 indicators of 3 dimensions. The attributes of the personal dimension were professional self-awareness, professional competence, the attribute of organizational dimension was respect and recognition of the organization, the attributes of social dimension were social trust and respect, driving forces of job retention. CONCLUSION: The job-esteem of hospital nurses is defined as beliefs and values used to evaluate or as expectations of self in the job through which hospital nurses van find professional self-awareness and competence, identify respect and recognition of the organization, recognize the driving forces of social trust, respect and job maintenance. This study is meaningful in that the concept of job respect of hospital nurses was analyzed and basic data for the development of a job-esteem scale for hospital nurses was provided.
Humans ; Mental Competency ; Professional Competence

PURPOSE: The purpose of this study was to identify whether career decision-making self-efficacy and social support provide a moderating effect between career barriers and job-seeking stress for 4th year nursing students preparing for employment. METHODS: A self report questionnaire survey was completed by 300 4th year nursing students at 6 universities located in 4 cities in Korea. Data were gathered during July, 2017 and analyzed using the SPSS 20.0 program. RESULTS: There was significant positive correlation between career barriers and job-seeking stress, and negative correlation between career decision-making self-efficacy, social support and job-seeking stress. Career decision-making self-efficacy and social support had significant moderating effects in the relationship between career barriers and job-seeking stress among nursing students preparing for employment. CONCLUSION: The results of the study indicate that career decision-making self-efficacy and social support are important factors in reducing job-seeking stress among nursing students preparing for employment. Therefore, to understand various job-seeking stress factors among nursing students preparing for employment, consideration must be given to the development of educational programs and support systems to improve career decision-making self-efficacy and social support.
Employment ; Humans ; Korea ; Nursing ; Self Report ; Students, Nursing

Purpose: The purpose of this study was to develop the Job Esteem Scale for Korean Nurses (JES-KN) and verify its validity and reliability. Methods: Preliminary items were based on the attributes and indicators elicited from a concept analysis study on Korean nurses’ job-esteem.The final preliminary tool for the main survey was confirmed through the content validity test of 10 experts and preliminary surveyof 20 hospital nurses. The final preliminary scale was used on 350 hospital nurses in the scale testing phase for the main survey designedto test the validity and reliability of the scale. Results: The final scale consisted of 28 items and 6 factors, these factor explained 66.6% ofthe total variance. The correlation between the total score and factors ranged from .64 and .84, validating that each sub-factor is suitableto explain job esteem. The correlation coefficient between this scale and the Job Satisfaction Scale for Clinical Nurses ranged from .41 to.70, and the internal consistency for the scale using Cronbach’s a for the total items was .94. Conclusion The JES-KN is a valid and reliabletool that reflects the reality of clinical sites accordingly. The JES-KN may well be used effectively to assess and evaluate the job esteem ofKorean nurses.

PURPOSE: This study was done to evaluate factors affecting active early detection behaviors of breast cancer and performance rate of breast self examination (BSE), physical examination and mammography. METHODS: The participants were 264 women from an outpatient breast clinic of a university hospital and materials were collected from March 2007 to February 2008 using a structured questionnaire. The data were analyzed using chi-square test, logistic analysis. RESULTS: The rate for BSE was 58.3%, for physical examination, 55.3% and for mammography experience, 63.4%. Women with all of these active early detection behaviors accounted for 31.8% of the participants. Various factors such as age, income, marital status, and menopause showed increased significant performance rate. The explanation power of logistic model was 48.5%, and was significant for age, income and health belief. Factors related to high performance rate were being over 40 years of age, high income and high health belief score. CONCLUSION: Active early detection behaviors were not high in spite of marked increases in breast cancer incidence. Encouragement for women practicing early detection behavior is important, but there is also a need to develop interest and support for the low performance group. More sustained education and public relations are needed to further improve active early detection behavior.
Breast ; Breast Neoplasms ; Breast Self-Examination ; Female ; Humans ; Incidence ; Logistic Models ; Mammography ; Marital Status ; Menopause ; Outpatients ; Physical Examination ; Public Relations ; Surveys and Questionnaires

The aim of this study was to analyze long-term survivals in patients with stage IB to IIA cervical cancer treated by neoadjuvant chemotherapy setting. Between February 1989 and January 1998, 94 women with previously untreated stage IB to IIA carcinoma of the uterine cervix who received cisplatin based neoadjuvant chemotherapy were enrolled in this study. All of patients with chemoresponse (complete response, n=15; partial response, n=47) and 16 patients with chemoresistance received radical surgery (RS group). The other 16 patients with chemoresistance received radiotherapy for definite treatment (RT group). In the RS group, the 10 yr survival estimation in patients with bulky tumors (diameter > or =4 cm, n=26) was similar to that with non-bulky tumors (83.3% vs. 89.3%, p=NS). In selected patients with chemoresistance, those treated by radiotherapy (n=16) showed significantly poorer survivals than those treated by radical surgery (n=16) [10 yr survival rates of RT (25%) vs. RS (76.4%), p=0.0111]. Our results support that a possible therapeutic benefit of neoadjuvant chemotherapy plus radical surgery is only in patients with bulky stage IB to IIA cervical cancer. In cases of chemoresistance, radical surgery might be a better definite treatment option.
Uterine Cervical Neoplasms/drug therapy/*radiotherapy/*surgery ; Treatment Outcome ; Survival Analysis ; Retrospective Studies ; Prognosis ; Neoplasm Staging ; Multivariate Analysis ; Middle Aged ; Humans ; Follow-Up Studies ; Fluorouracil/administration & dosage ; Female ; Drug Resistance, Neoplasm ; Combined Modality Therapy ; Cisplatin/administration & dosage ; Chemotherapy, Adjuvant ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Adult