M llerian anomalies have been infrequently encountered clinical problem for the obstetrician gynecologist, incidence was estimated to occur in 1% to 6% of all women. Recently, the use of vaginal ultrasound, MRI and endoscopic techniques have led to more accurate description and classification of m llerian anomalies. This report of a complete uterine septum with duplication of the cervix and a longitudinal vaginal septum with hemivaginal stricture represents a unique case of septate uterus, which to our knowledge previously has not been reported.
Cervix Uteri* ; Classification ; Constriction, Pathologic* ; Female ; Humans ; Incidence ; Magnetic Resonance Imaging ; Ultrasonography ; Uterus*

OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation between FAF1 and HSP70 in ovarian cancer. METHODS: The patient group consisted of 29 unrelated Korean women diagnosed as ovarian cancers and control samples were obtained from 7 patients who underwent oophorectomy for benign disease of uterus, and normal ovary was confirmed histologically from biopsy. We examined FAF1 and HSP70 expression by western blot analysis and immunohistochemical staining in normal ovary and ovarian cancer. Furthermore, we examined a correlation between FAF1 and HSP70 in ovarian cancer. RESULTS: The expression of FAF1 was lower in ovarian cancer than that in normal ovary (P=0.02), and the expression of HSP70 was increased in ovarian cancer in comparison to that in normal ovary (P=0.03). The expression of FAF1 was decreased in advanced stages (stage III or stage IV) as compared with early stages (stage I or stage II) (P=0.01). The expression of HSP70 was not significantly related with ovarian cancer histology (P=0.10), but the expression of HSP70 was most increased with papillary serous carcinomas and undifferentiated ovarian cancer. The expression of FAF1 was inversely correlated with the expression of HSP70 in ovarian cancer (Spearman correlation coefficience=-0.47). CONCLUSION: We concluded that the expression of FAF1 or HSP70 each seems to have a meaning as a biomarker for early detection of ovarian cancer. The expressions of FAF1 and HSP70 seem to be more valuable in predicting ovarian cancer when used together because of their inverse correlation. This is the first study about the expression of FAF1 in ovarian cancer and the correlation between FAF1 and HSP70 expression in ovarian cancer.
Biopsy ; Blotting, Western ; Female ; HSP70 Heat-Shock Proteins* ; Humans ; Ovarian Neoplasms* ; Ovariectomy ; Ovary ; Uterus

OBJECTIVE: The aim of this study was to explore the association between E-cadherin promoter -160C>A polymorphism and the risk of cervical cancer and cervical intraepithelial neoplasm (CIN) in a Korean population. METHODS: We investigate 107 patients with histopathologically confirmed cervical cancer, 119 patients with histopathologically confirmed CIN and 112 control group women who were surgically proven to have normal cervices. The genetic distribution of E-cadherin promoter -160C>A polymorphism were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products. RESULTS: We found no overall association between each individual E-cadherin promoter -160C>A genotype and the risk of cervical cancer and CIN. In the cervical cancer group, the allele frequency of C was 83.6%, in the control group 83.5%, showing no significant difference (p=0.941). Similarly, in the CIN group, the allele frequency of C was 81.9%, in the control group 83.5%, showing no significant difference (p=0.645). A subgroup analysis of the clinical parameters in CC, CA, AA genotype also showed no significant difference suggesting the lack of an association between E-cadherin promoter -160C>A polymorphism and cervix cancer stages (p=0.413), then its polymorphism and HPV infection (p=0.634). CONCLUSION: our results show that Korean women with specific polymorphism in E-cadherin promoter -160C>A are neither more susceptible to develop the cervical cancer or CIN nor more valuable for the cancer progression.
Cadherins ; Cervical Intraepithelial Neoplasia ; Female ; Gene Frequency ; Genotype ; Humans ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Uterine Cervical Neoplasms

Intra-abdominal desmoplastic small round cell tumor has been described in the literature since 1989. It is characterized by the occurrence in ages less than 40 with male predominance, an intra-abdominal location, and small round to oval shaped tumor cells with divergent differentiation in the background of the desmoplastic stroma. We recently experienced this tumor in an inguinal lymph node of a 36-year-old man. It is suspected that it metastasized from a lower intra-abdominal tumor. Immunohistochemical stains for keratin, epithelial membrane antigen, vimentin, S-100 protein and neuron specific enolase were positive. This is the first documented case in Korea. Herein, we report on this tumor with a review of literature.
Male ; Humans

No abstract available.
Humans ; Infant, Newborn* ; Mothers* ; Vitamin E* ; Vitamins*

Systemic candidiasis is a fatal fungal infection and its diagnosis is often difficult because Candida organism may be cultured from blood specimens in only 25% of the patients. The triad of systemic candidiasis is fever, papular rash, and diffuse muscle tenderness. Therefore, the recognition of the characteristic cutaneous lesions of disseminated candidiasis allows earlier diagnosis and treatment. The cutaneous lesion usually consists of red or purpuric papules, some with pale centers, abscess, necrotic lesion, hemorrhage and skin lesion mimicking ecthyma gangrenosum. We report a rare case of disseminated candidiasis presented as multiple subcutaneous nodule-typed skin lesions.
Abscess ; Candida ; Candidiasis* ; Diagnosis ; Ecthyma ; Exanthema ; Fever ; Hemorrhage ; Humans ; Myalgia ; Skin

No abstract available.
Dislocations* ; Knee*

BACKGROUND: Dermatophytoses account for 5~15% of disorders seen in pediatric clinics. Clinical charateristics and therapeutic strategies of children are differ from adults. OBJECTIVE: We performed retrospective study in order to observe clinical and mycological features of dermatophytoses in pediatric patients including therapeutic strategies. METHODS: This clinical and mycological investigation was made with 404 cases of dermatophytoses among out-patients in the Department of Dermatology of Severance Hospital, Yonsei University College of Medicine, from February, 1996 to January, 2001. RESULTS: Dermatophytoses showed high incidence in 14~15 years of age group (54 cases), less than 1 year of age group (35 cases) and 13~14 years of age group (32 cases). The ratio of male to female was 1.3 : 1. Especially in patients with tinea cruris, which was the most prominent diseases showing male predominance, the sex ratio was 3.4 : 1. The incidence of each type of dermatophytoses was the highest in Tinea (T.) corporis (21.6%), followed by T. capitis (20.3%), T. pedis (19.8%), T. cruris (13.6%), Onychomycosis (13.6%), T. faciei (7.5%) and T. manus (3.6%). The mean-duaration before diagnosis was longest in onychomycosis (529 days), followed by T. cruris (367 days), T. pedis (273 days), T. capitis (144 days), T. manus (139 days), T. corporis (138 days) and T. faciei (77 days). The most common cultured organism was Microsporum (M.) canis (24 cases) followed by Trichophyton (T.) mentagrophytes (22 cases), T. rubrum (20 cases) and M. gypseum (1 case). The treatment with topical antifungal agents (62%) was more commonly used than the treatment with oral antifungal agents (38%). The type of dermatophytoses that is the most resistant to topical and oral antifungal agents was tinea capitis caused by M. canis. CONCLUSION: The incidence of T. capitis in children was much higher than that in adults and the response to antifungal agents in children showed resistance to first-line therapy in T. capitis caused by M. canis.
Adult ; Antifungal Agents ; Child* ; Dermatology ; Diagnosis ; Female ; Humans ; Incidence ; Male ; Microsporum ; Onychomycosis ; Outpatients ; Retrospective Studies ; Sex Ratio ; Tinea Capitis ; Tinea* ; Trichophyton

BACKGROUND: Dermatophytoses account for 5~15% of disorders seen in pediatric clinics. Clinical charateristics and therapeutic strategies of children are differ from adults. OBJECTIVE: We performed retrospective study in order to observe clinical and mycological features of dermatophytoses in pediatric patients including therapeutic strategies. METHODS: This clinical and mycological investigation was made with 404 cases of dermatophytoses among out-patients in the Department of Dermatology of Severance Hospital, Yonsei University College of Medicine, from February, 1996 to January, 2001. RESULTS: Dermatophytoses showed high incidence in 14~15 years of age group (54 cases), less than 1 year of age group (35 cases) and 13~14 years of age group (32 cases). The ratio of male to female was 1.3 : 1. Especially in patients with tinea cruris, which was the most prominent diseases showing male predominance, the sex ratio was 3.4 : 1. The incidence of each type of dermatophytoses was the highest in Tinea (T.) corporis (21.6%), followed by T. capitis (20.3%), T. pedis (19.8%), T. cruris (13.6%), Onychomycosis (13.6%), T. faciei (7.5%) and T. manus (3.6%). The mean-duaration before diagnosis was longest in onychomycosis (529 days), followed by T. cruris (367 days), T. pedis (273 days), T. capitis (144 days), T. manus (139 days), T. corporis (138 days) and T. faciei (77 days). The most common cultured organism was Microsporum (M.) canis (24 cases) followed by Trichophyton (T.) mentagrophytes (22 cases), T. rubrum (20 cases) and M. gypseum (1 case). The treatment with topical antifungal agents (62%) was more commonly used than the treatment with oral antifungal agents (38%). The type of dermatophytoses that is the most resistant to topical and oral antifungal agents was tinea capitis caused by M. canis. CONCLUSION: The incidence of T. capitis in children was much higher than that in adults and the response to antifungal agents in children showed resistance to first-line therapy in T. capitis caused by M. canis.
Adult ; Antifungal Agents ; Child* ; Dermatology ; Diagnosis ; Female ; Humans ; Incidence ; Male ; Microsporum ; Onychomycosis ; Outpatients ; Retrospective Studies ; Sex Ratio ; Tinea Capitis ; Tinea* ; Trichophyton

BACKGROUND: This study was designed to elucidate which factors affected left ventricular hypertrophy (LVH) on ECG in middle-aged normotensive healthy men. METHODS: A total of 436 normotensive office workers who visited the health examination center of St. Mary's Hospital of Catholic University in Korea from August 1 to October 30, 2002, were divided into two groups; 138 with LVH on ECG were grouped as LVH and 298 who showed no LVH on ECG were grouped as non-LVH. Questionnaires on history of smoking, drinking and exercise were filled out, and body fat, body mass index, blood pressure and biochemical markers were measured. Related factors with LVH on ECG were statistically analyzed with Chi-square test, t-test and logistic regression. RESULTS: The mean systolic and diastolic blood pressure and mean alcohol intake (g/day) were significantly elevated in the LVH group (P<0.005). The non-LVH group had a tendency to show increased pulse rate (P=0.058), a higher percentage of people who did not exercise at all, and a lower percentage of people who exercised regularly (P=0.056). The smoking history, BMI and other biochemical markers showed no significant differences (P>0.1). On logistic regression analysis, there was a significant increase in odds ratio for LVH with increase in diastolic blood pressure (adjusted OR 1.048, 95% CI 1.019~1.077), with exercise more than 3 times a week (adjusted OR 2.317, 95% CI 1.258~4.269) and with increased alcohol intake (adjusted OR 1.010, 95% CI 1.001~1.019). In contrast, odds ratio for LVH decreased as the pulse rate per minute increased (adjusted OR 0.974, 95% CI 0.952~0.997). In detailed analysis comparing those who exercised regularly more than 3 times a week with those who exercised less than 3 times a week, the increase in diastolic blood pressure was a significant factor which increased the odds ratio for LVH in both groups. A significant increase in the odds ratio by mean alcohol intake per day was shown only in a group who exercised less than 3 times a week. CONCLUSION: As a result of this study, in normotensive middle-aged men with LVH on ECG, patients should be monitored for regular exercise and increase in diastolic blood pressure should be regarded as a risk factor for LVH on ECG irrespective of exercise. In those who do not do exercise regularly, diastolic blood pressure as well as alcohol intake should be evaluated as risk factors for LVH
Adipose Tissue ; Biomarkers ; Blood Pressure ; Body Mass Index ; Drinking ; Electrocardiography* ; Heart Rate ; Humans ; Hypertrophy, Left Ventricular* ; Korea ; Logistic Models ; Male ; Odds Ratio ; Risk Factors ; Smoke ; Smoking ; Surveys and Questionnaires