PURPOSE: To report the efficacy of tarsal marginal rotation with blepharoplasty in the management of cicatricial entropion of the upper eyelid. METHODS: In 9 consecutive patients, 14 eyelids with moderate cicatricial entropion of the upper eyelid were enrolled in this study. All 14 eyelids underwent tarsal margin rotation with blepharoplasty. In cases where one eyelid was involved, the fellow eyelid underwent upperlid blepharoplasty at the same time. The mean follow-up period was 17.7 months (range, 11 to 53 months). RESULTS: In all 14 upper eyelids, the eyelashes rotated away from the surface of the eye postoperatively. There was not recurrence in 13 eyelids and the effect of correction was maintained for the follow-up period. However, in one eyelid the cicatricial entropion recurred after months. Tarsal margin rotation was repeated and there was no recurrence for 6 months. CONCLUSIONS: Tarsal margin rotation with blepharoplasty appears to be effective in managing cicatricial entropion of the upper eyelid in both functional and cosmetic aspects.
Blepharoplasty* ; Entropion* ; Eyelashes ; Eyelids* ; Follow-Up Studies ; Humans ; Recurrence

Phenytoin is useful medication in patients with seizure disorders. Hematologic side effects of phenytoin treatment are rare. Especially, isolated thrombocytopenia is very rare. This condition is presumably the result of an immune-mediated process caused by antiplatelet antibodies induced by a drug as a hapten. Thrombocytopenia as a side effect of the phenytoin treatment usually has been reported in adults. It generally occurs at 2 to 4 weeks after initiation of therapy and resolved at 2 to 28 days after discontinuation of the phenytoin. In our case, the thrombocytopenia developed on the 2nd day of therapy and resolved on the 4th day after discontinuation of the phenytoin. We report a 3-year-old girl who developed reversible thrombocytopenia during the phenytoin treatment.
Adult ; Antibodies ; Child, Preschool ; Epilepsy ; Female ; Humans ; Phenytoin ; Thrombocytopenia*

Temporal triangular alopecia is a triangular or oval shaped non-scarring alopecia, occurring on the temporal side of the scalp, which was first reported by Sabourand in 1950. It usually occurs in the childhood. There is no treatment for this disorder except for surgery. In this article, we report a case of focal alopecia which was successfully treated with micropigmentation.
Alopecia* ; Scalp

PURPOSE: The subconjunctival sparganosis is rare tissue helminthiasis which developed frequently in abdominal, urethral, ureteral and vertebral cases. Authors report a case of sparganosis in the subconjunctival mass. METHODS: A 51-year-old man with reddish non painful mass in his left eye on the subconjunctiva that was unresponsive to medications for 6months was evaluated and treated surgically. On surgical exploration, a white thread-like plerocercoid 0.2 x 4.7 cm in size was extracted from the subconjunctival mass and actively motile in the bottle filled with saline. It was confirmed as a typical sparganum under histologic examination. Three months after surgery, the lesion disappeared completely. RESULTS: Although rare, parasitic disease should be suspected in a palpable subconjuntival mass unresponsive to the medical treatment.
Helminthiasis ; Humans ; Middle Aged ; Parasitic Diseases ; Sparganosis* ; Sparganum ; Ureter

Topical photodynamic therapy (PDT) via topical 5-aminolevulinic acid (ALA) is potentially useful for the treatment of basal cell carcinoma. However, as a photosensitizer used in PDT, methyl aminolevulinate (MAL) can replace ALA, because MAL has more advantages than ALA. We treated two patients with basal cell carcinoma using MAL-PDT. Topical MAL-PDT may be a safe and effective treatment modality for basal cell carcinoma.
Carcinoma, Basal Cell ; Humans ; Photochemotherapy ; Triazenes

The prognostic significance of the squamous cell carcinomas of the oral and oropharynx have been evaluated to identify those features associated with aggressive biologic behavior according to the immunologic and histologic characteristics. For determining prognostic indicators, the authors performed immunohistochemical staining of p53 and epidermal growth factor receptor(EGFR) in 29 cases of squamous cell carcinomas of the oral and oropharynx. The expression rate of p53 was 51.7%, that of EGFR was 96.6%, and overexpression rate of EGFR was 41.4%, however there were no statistical significance between the reactivity of EGFR, p53 and clinicopathological features such as primary stage, nodal stage, clinical stage, death and histologic grade.
Carcinoma, Squamous Cell* ; Epidermal Growth Factor* ; Oropharynx ; Receptor, Epidermal Growth Factor*

INTRODUCTION: The first aim of this study was to isolate the dental tissue-derived stem cells from the dental follicle (DF), dental pulp (DP), and root apical papilla (RAP) of the extracted wisdom teeth. Second was to evaluate their characterization with the expressions of transcription factors and cell surface markers. Finally, their ability of the in vitro multi-lineage differentiations into osteogenic and adipogenic cells were compared, respectively. MATERIALS AND METHODS: Dental tissues, including dental follicle, dental pulp, and root apical papilla, were separated in the extracted wisdom teeth. These three dental tissues were cultured in Dulbecco's modified Eagle's medium (DMEM) with supplements, respectively. After passage 3, the homogeneous shaped dental tissue-derived cells were analyzed the expression of transcription factors (Oct-4, Nanog and Sox-2) and cell surface markers (CD44, CD90 and CD105) with reverse transcription polymerase chain reaction (RT-PCR) and fluorescence-activated cell sorting (FACS) analysis. In order to evaluate in vitro multi-lineage differentiations, the culture media were changed to the osteogenic and adipogenic induction mediums when the dental tissue-derived cells reached to passage 3. The characteristics of these three dental tissue-derived cells were compared with immunohistochemistry. RESULTS: During primary culture, heterogenous and colony formatted dental tissue-derived cells were observed in the culture plates. After passage 2 or 3, homogenous spindle-like cells were observed in all culture plates. Transcription factors and mesenchymal stem cell markers were positively observed in all three types of dental tissue-derived cells. However, the quantity of expressed transcription factors was most large in RAP-derived cells. In all three types of dental tissue-derived cells, osteogenic and adipogenic differentiations were observed after treatment of specific induction media. In vitro adipogenic differentiation was similar among these three types of cells. In vitro osteogenic differentiation was most strongly and frequently observed in the RAP-derived cells, whereas rarely osteogenic differentiation was observed in the DP-derived cells. CONCLUSION: These findings suggest that three types of human dental tissue-derived cells from extracted wisdom teeth were multipotent mesenchymal stem cells, have the properties of multi-lineage differentiations. Especially, stem cells from root apical papilla (SCAP) have much advantage in osteogenic differentiation, whereas dental follicle cells (DFCs) have a characteristic of easy adipogenic differentiation.
Culture Media ; Dental Pulp ; Dental Sac ; Durapatite ; Flow Cytometry ; Humans ; Imidazoles ; Immunohistochemistry ; Mesenchymal Stromal Cells ; Molar, Third ; Nitro Compounds ; Polymerase Chain Reaction ; Reverse Transcription ; Stem Cells ; Transcription Factors

Actinic cheilitis is a pathologic condition affecting mainly the lower lip caused by long term exposure of the lips to UV radiation in sunlight. Analogous to actinic keratosis of the skin, actinic cheilitis is considered as a precancerous lesion and may develop into squamous cell carcinoma. Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizing agent, oxygen, and light of a specific wavelength to produce controlled cell death. Photodynamic therapy (PDT) using the new highly selective photosensitizer methyl aminolevulinate (MAL) (Metvix(R), Galderma, U.K.) is a promising new treatment modality for premalignant and malignant skin lesions. We report a case of actinic cheilitis treated with PDT using MAL, with satisfactory outcome in both clinical and pathological aspects.
Actins ; Carcinoma, Squamous Cell ; Cell Death ; Cheilitis ; Keratosis, Actinic ; Light ; Lip ; Oxygen ; Photochemotherapy ; Skin ; Sunlight ; Triazenes

BACKGROUND: The brachial-ankle pulse wave velocity (baPWV) is a useful parameter to assess arterial stiffness. However, it is difficult to evaluate arterial stiffness in hypertensive patients because the baPWV is affected by the blood pressure itself. This study was designed to estimate the relationship between the change of the blood pressure parameters and the baPWV (delta baPWV) when hypertensive patients were subjected to an acute reduction of blood pressure. METHODS: Thirty patients with essential hypertension and whose blood pressure was higher than 140/90 mmHg were enrolled. In all the patients, the blood pressure and baPWV were measured using an automatic waveform analyzer with the patients at a resting state. When the reduction of blood pressure was more than 10 mmHg after sublingual administration of nifedipine 10 mg, then the blood pressure and baPWV were measured again in the same manner and then they were compared with the baseline values. Spearman's correlation and multiple linear regression tests were performed to estimate the relationship between the change of the blood pressure parameters (delta SBP, delta DBP, delta MAP and delta PP) and the delta baPWV. RESULTS: The baPWV was significantly decreased shortly after the administration of nifedipine (1903.6+/-305.2 cm/sec vs. 1716+/-252.0 cm/sec, respectively, p<0.01). The delta baPWV was correlated with the delta SBP (r=0.550, p<0.01), delta DBP (r=0.386, p<0.05), delta MAP (r=0.441, p<0.05), and delta PP (r=0.442. p<0.05). On the multiple regression analysis, the delta SBP was the only significant variable for predicting the delta baPWV, and the linear equation was delta baPWV=8.7 x SBP-48. CONCLUSIONS: The baPWV is affected by the systolic blood pressure level to a large degree and careful attention must be paid to the blood pressure level when evaluating arterial stiffness with using the baPWV.
Administration, Sublingual ; Aged ; Blood Flow Velocity ; Blood Pressure/*drug effects/physiology ; Brachial Artery/*physiopathology ; Female ; Humans ; Hypertension/diagnosis/*physiopathology ; Male ; Middle Aged ; Nifedipine/administration & dosage ; Pulse ; Systole/physiology ; Vasodilator Agents/administration & dosage