1.Paralytic Ileus and Prophylactic Gastrointestinal Motility Medication after Spinal Operation.
Chang Hyun OH ; Gyu Yeul JI ; Seung Hwan YOON ; Dongkeun HYUN ; Hyeong Chun PARK ; Yeo Ju KIM
Yonsei Medical Journal 2015;56(6):1627-1631
PURPOSE: To investigate the prevalence of paralytic ileus after spinal operation in the supine or prone operative position and to determine the efficacy of prophylactic gastrointestinal motility medications in preventing symptomatic paralytic ileus after a spinal operation. MATERIALS AND METHODS: All patients received spinal surgery in the supine or prone operative position. The study period was divided into two phases: first, to analyze the prevalence of radiographic and symptomatic paralytic ileus after a spinal operation, and second, to determine the therapeutic effects of prophylactic gastrointestinal motility medications (postoperative intravenous injection of scopolamine butylbromide and metoclopramide hydrochloride) on symptomatic paralytic ileus after a spinal operation. RESULTS: Basic demographic data were not different. In the first phase of this study, 27 patients (32.9%) with radiographic paralytic ileus and 11 patients (13.4%) with symptomatic paralytic ileus were observed. Radiographic paralytic ileus was more often noted in patients who underwent an operation in the prone position (p=0.044); whereas the occurrence of symptomatic paralytic ileus was not different between the supine and prone positioned patients (p=0.385). In the second phase, prophylactic medications were shown to be ineffective in preventing symptomatic paralytic ileus after spinal surgery [symptomatic paralytic ileus was observed in 11.1% (4/36) with prophylactic medication and 16.7% (5/30) with a placebo, p=0.513]. CONCLUSION: Spinal surgery in the prone position was shown to increase the likelihood of radiographic paralytic ileus occurrence, but not symptomatic paralytic ileus. Unfortunately, the prophylactic medications to prevent symptomatic paralytic ileus after spine surgery were shown to be ineffective.
Adjuvants, Anesthesia/*administration & dosage/pharmacology
;
Adult
;
Aged
;
Antiemetics/*administration & dosage/pharmacology
;
Female
;
Gastrointestinal Motility/*drug effects/physiology
;
Humans
;
Injections, Intravenous
;
Intestinal Pseudo-Obstruction/drug therapy/epidemiology/*prevention & control
;
Lumbar Vertebrae/radiography/*surgery
;
Male
;
Metoclopramide/*administration & dosage/pharmacology
;
Middle Aged
;
Postoperative Complications/epidemiology
;
Prevalence
;
Prone Position
;
Prospective Studies
;
Republic of Korea
;
Scopolamine Hydrobromide/*administration & dosage/*pharmacology
;
Spinal Fusion/*adverse effects
;
Supine Position
;
Treatment Outcome
2.Interobserver and Intraobserver Reliability of Sub-Axial Injury Classification and Severity Scale between Radiologist, Resident and Spine Surgeon.
Woo Jin LEE ; Seung Hwan YOON ; Yeo Ju KIM ; Ji Yong KIM ; Hyung Chun PARK ; Chon Oon PARK
Journal of Korean Neurosurgical Society 2012;52(3):200-203
OBJECTIVE: The sub-axial injury classification (SLIC) and severity scale was developed to decide whether to operate the cervical injured patient or not, but the reliability of SLIC and severity scale among the different physicians was not well known. Therefore, we evaluated the reliability of SLIC among a spine surgeon, a resident of neurosurgery and a neuro-radiologist. METHODS: In retrograde review in single hospital from 2002 to 2009 years, 75 cases of sub-axial spine injured patients underwent operation. Each case was blindly reviewed for the SLIC and severity scale by 3 different observers by two times with 4 weeks interval with randomly allocated. The compared axis was the injury morphology score, the disco-ligamentous complex score, the neurological status score and total SLIC score; the neurological status score was derived from the review of medical record. The kappa value was used for the statistical analysis. RESULTS: Interobserver agreement of SLIC and severity scale was substantial agreement in the score of injury morphology [intraclass correlation (ICC)=0.603] and total SLIC and severity sacle (ICC value=0.775), but was fair agreement in the disco-ligamentous complex score (ICC value=0.304). Intraobserver agreements were almost perfect agreement in whole scales with ICC of 0.974 in a spine surgeon, 0.948 in a resident of neurosurgery, and 0.963 in a neuro-radiologist. CONCLUSION: The SLIC and severity scale is comprehensive and easily applicable tool in spine injured patient. Moreover, it is very useful tool to communicate among spine surgeons, residents of neurosurgery and neuro-radiologists with sufficient reproducibility.
Axis, Cervical Vertebra
;
Humans
;
Medical Records
;
Neurosurgery
;
Spine
;
Weights and Measures
3.Two Cases of Gastric Mucosal Calcinosis.
Ju Chun YEO ; Dong Uk JU ; Se Young LEE ; Sung Woo EUM ; Jai Hyun LEE ; Se Hwan KIM ; Chang Keun PARK ; Seung Yup LEE ; Hyun Soo KIM ; Mi Jin KOO
Korean Journal of Gastrointestinal Endoscopy 2006;33(4):230-234
Gastric mucosal calcinosis (GMC) is a very rare condition that is characterized by the nodular deposition of calcium salts in the gastric mucosa. It has been associated with renal failure, gastric cancer, ingestion of aluminum- containing antacids and the use of sucralfate in organ transplant patients. The etiology of this condition is uncertain, but several theories have been proposed; the condition is due secondarily to hyperparathyroidism in renal failure and to the alkalinization of the gastric mucosa. We report here on two patients who had long-term use of bismuth and/or aluminum-containing antacids to treat their gastro-esophageal reflux symptoms. The esophagogastroduodenoscopy revealed acute gastritis patterns, and GMC was confirmed histologically with biopsy. When one patient stopped ingesting bismuth-containing antacid solution, the follow-up esophagogastroduodenoscopy and the biopsy revealed a completely improved state. We report here on these interesting cases and we include a brief review of the literature.
Antacids
;
Biopsy
;
Bismuth
;
Calcinosis*
;
Calcium
;
Eating
;
Endoscopy, Digestive System
;
Follow-Up Studies
;
Gastric Mucosa
;
Gastritis
;
Gastroesophageal Reflux
;
Humans
;
Hyperparathyroidism
;
Renal Insufficiency
;
Salts
;
Stomach Neoplasms
;
Sucralfate
;
Transplants
4.First-pass Stress Perfusion MR Imaging Findings of Apical Hypertrophic Cardiomyopathy: with Relation to LV Wall Thickness and Late Gadolinium-enhancement.
Jin Young YOO ; Eun Ju CHUN ; Yeo Koon KIM ; Sang Il CHOI ; Dong Ju CHOI
Journal of the Korean Society of Magnetic Resonance in Medicine 2014;18(1):7-16
PURPOSE: To evaluate the prevalence and pattern of perfusion defect (PD) on first-pass stress perfusion MR imaging in relation with the degree of left ventricular hypertrophy (LVH) and late gadolinium-enhancement (LGE) in patients with apical hypertrophic cardiomyopathy (APH). MATERIALS AND METHODS: Cardiac MR imaging with first-pass stress perfusion, cine, and LGE sequence was performed in 26 patients with APH from January 2008 to December 2012. We analyzed a total of 416 segments for LV wall thickness on end-diastolic phase of cine images, and evaluated the number of hypertrophied segment and number of consecutive hypertrophied segment (NCH). We assessed the presence or absence of PD and LGE from all patients. If there was PD, we subdivided the pattern into sporadic (sporadic-PD) or ring (ring-PD). Using univariate logistic method, we obtained the independent predictor for presence of overall PD and ring-PD. RESULTS: PD on stress perfusion MRI was observed in 20 patients (76.9%), 12 of them (60%) showed ring-PD. Maximal LV wall thickness and number of hypertrophied segment were independent predictors for overall PD (all, p < 0.05). NCH with more than 3 segments was an additional independent factor for ring-PD. However, LGE was not statistically related with PD in patients with APH. CONCLUSION: About three quarters of the patients with APH showed PD, most of them represented as ring-PD. LVH degree or distribution was related with pattern of PD, however, LGE was not related with PD. Therefore, the clinical significance of PD in the patients with APH seems to be different from those with non-APH, and further comparison study between the two groups should be carried out.
Cardiomyopathy, Hypertrophic*
;
Humans
;
Hypertrophy, Left Ventricular
;
Magnetic Resonance Imaging*
;
Perfusion*
;
Prevalence
5.Association of the vascular endothelial damage and estrogen, progesterone.
Mi Kyoung KIM ; Ji Ae KIM ; Yeo Jin JEON ; Jong Soon PARK ; Mi Hye PARK ; Suk Hyo SUH ; Sun Hee CHUN ; Jung Ja AHN ; Young Ju KIM
Korean Journal of Obstetrics and Gynecology 2007;50(3):429-438
OBJECTIVE: The aim of this study were to examine the serum level of estradiol, estriol, progesterone, oxidized LDL in preeclamtic patients and to evaluate the protective effects of estrogen and progesterone against lysophosphatidylcholine (LPC) induced cell death in Human umbilical vein endothelial cells (HUVECs). METHODS: We analysed the serum level of estradiol, estriol, progesterone, oxidized LDL in patients with preeclampsia and control. We used LPC to induce cell death in HUVECs. For cytotoxic assay, we did LDL assay for cell death and Resazurin assay for cell viability. HUVECs were exposed to various concentrations of LPC, LPC+estrogen, LPC+progesterone and we did cytotoxic assay. RESULTS: The serum estradiol, estriol were lower in the preeclamptic patients (P<0.05). Oxidized LDL were higher in the preeclamptic patients(P<0.05). LPC induced cell death in a concentration-dependant manner. Estrogen or progesterone inhibited LPC-induced cell death in a concentration-dependant manner (P<0.05). CONCLUSION: Estrogen and progesterone attenuated LPC-induced cytotoxicity. The results suggest that Oxidized LDL induced endothelial damage in preeclampsia may be induced by low serum estradiol, estriol and progesterone levels and prevented by estrogen and progesterone addition.
Cell Death
;
Cell Survival
;
Estradiol
;
Estriol
;
Estrogens*
;
Human Umbilical Vein Endothelial Cells
;
Humans
;
Lysophosphatidylcholines
;
Pre-Eclampsia
;
Progesterone*
6.Additive Role of Coronary Magnetic Resonance Angiography for the Evaluation of Coronary Artery Disease.
Min Jeong KIM ; Yeonyee E YOON ; Jin Joo PARK ; Yeo Koon KIM ; Eun Ju CHUN ; Sang Il CHOI ; Goo Young CHO
Korean Circulation Journal 2017;47(3):409-412
Coronary magnetic resonance angiography (CMRA) allows a noninvasive assessment of the coronary anatomy without exposing the patients to radiation. It is also superior to coronary computed tomography angiography (CCTA) for the evaluation of luminal narrowing in heavily calcified coronary segments. We report a case with triple-vessel disease, but it could not be accurately assessed by CCTA because of calcification and lack of a significant perfusion defect or myocardial scarring on cardiac magnetic resonance imaging (MRI). However, whole-heart CMRA performed as part of the cardiac MRI protocol demonstrated significant triple-vessel disease with left main involvement, confirmed by subsequent invasive angiography with a fractional flow reserve measurement.
Angiography
;
Cicatrix
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Humans
;
Magnetic Resonance Angiography*
;
Magnetic Resonance Imaging
;
Perfusion
;
Phenobarbital
7.Congenital Giant Right Coronary Artery Aneurysm With Fistula to the Coronary Sinus and Persistent Left Superior Vena Cava in an Old Woman.
Soo Yong LEE ; Yong Hyun PARK ; Hye Ju YEO ; Chang Bae SOHN ; Dong Cheul HAN ; Jeong Su KIM ; Jun KIM ; June Hong KIM ; Kook Jin CHUN
Korean Circulation Journal 2012;42(11):792-795
The combination of coronary arteriovenous fistula to the coronary sinus (CS), dilatation of the entire length of coronary artery, coronary aneurysm and persistent left superior vena cava (PLSVC) is very rare. We present the case of a 63-year-old female admitted for dyspnea on exertion, orthopnea, and facial edema. Echocardiography detected a giant coronary artery with shunt flow, dilated CS and PLSVC and a coronary angiography reaffirmed these findings. The calculated ratio of pulmonary blood flow to systemic blood flow by cardiac catheterization was 1.53. After multidisciplinary review considering old age, hypoactivity due to underlying Parkinsonism and relatively small amount of shunt flow, medical therapy was chosen. The patient remained asymptomatic for 10 months after discharge without intervention.
Aneurysm
;
Arteriovenous Fistula
;
Cardiac Catheterization
;
Cardiac Catheters
;
Coronary Aneurysm
;
Coronary Angiography
;
Coronary Sinus
;
Coronary Vessels
;
Dilatation
;
Dyspnea
;
Echocardiography
;
Edema
;
Female
;
Fistula
;
Humans
;
Middle Aged
;
Parkinsonian Disorders
;
Vena Cava, Superior
8.Cervical Arthroplasty for Moderate to Severe Disc Degeneration: Clinical and Radiological Assessments after a Minimum Follow-Up of 18 Months: Pfirrmann Grade and Cervical Arthroplasty.
Chang Hyun OH ; Do Yeon KIM ; Gyu Yeul JI ; Yeo Ju KIM ; Seung Hwan YOON ; Dongkeun HYUN ; Eun Young KIM ; Hyeonseon PARK ; Hyeong Chun PARK
Yonsei Medical Journal 2014;55(4):1072-1079
PURPOSE: Clinical outcomes and radiologic results after cervical arthroplasty have been reported in many articles, yet relatively few studies after cervical arthroplasty have been conducted in severe degenerative cervical disc disease. MATERIALS AND METHODS: Sixty patients who underwent cervical arthroplasty (Mobi-C(R)) between April 2006 and November 2011 with a minimum follow-up of 18 months were enrolled in this study. Patients were divided into two groups according to Pfirrmann classification on preoperative cervical MR images: group A (Pfirrmann disc grade III, n=38) and group B (Pfirrmann disc grades IV or V, n=22). Visual analogue scale (VAS) scores of neck and arm pain, modified Oswestry Disability Index (mODI) score, and radiological results including cervical range of motion (ROM) were assessed before and after surgery. RESULTS: VAS and mean mODI scores decreased after surgery from 5.1 and 57.6 to 2.7 and 31.5 in group A and from 6.1 and 59.9 to 3.7 and 38.4 in group B, respectively. In both groups, VAS and mODI scores significantly improved postoperatively (p<0.001), although no significant intergroup differences were found. Also, cervical dynamic ROM was preserved or gradually improved up to 18 months after cervical arthroplasty in both groups. Global, segmental and adjacent ROM was similar for both groups during follow-up. No cases of device subsidence or extrusion were recorded. CONCLUSION: Clinical and radiological results following cervical arthroplasty in patients with severe degenerative cervical disc disease were no different from those in patients with mild degenerative cervical disc disease after 18 months of follow-up.
Adult
;
Arthroplasty/*methods
;
Cervical Vertebrae/pathology/surgery
;
Female
;
Follow-Up Studies
;
Humans
;
Intervertebral Disc/surgery
;
Intervertebral Disc Degeneration/*surgery
;
Male
;
Middle Aged
;
Range of Motion, Articular/physiology
;
Retrospective Studies
;
Spinal Diseases/surgery
;
Treatment Outcome
;
Young Adult
9.Prenatal diagnosis by isolation of fetal nucleated RBCs in maternal peripheral blood.
Yeo Jin JEON ; Kyung Hun KWON ; Hyo Sung HWANG ; So Hyun LEE ; Myung Geol PANG ; Jung Ja ANN ; Sun Hee CHUN ; Young Ju KIM
Korean Journal of Obstetrics and Gynecology 2007;50(6):850-857
OBJECTIVE: To identify prenatal fetal sex and chromosomal aneuploidies by FISH using isolation of fetal nucleated RBCs. METHODS: peripheral blood samples was collected from 37 women between 11 and 24 weeks of gestation. we tried to enrich nucleated RBCs morphologically by Kleihaur-Betke staining after double gradient centrifugation and magnetic activating cell sorting (MACS) from maternal blood. Fluorescence in situ hybridization (FISH) analyses with CEP X and CEP Y probes for K-B positive nucleated RBCs were performed to detect whether fetal cells were existed among nucleated RBCs by observation of sex chromosomes. RESULTS: The average number of K-B positive nucleated RBCs separated from 10ml of maternal blood was 17.3 (+/-17.2) and the maximum number of nucleated RBCs was 54. We observed FISH signals in nucleated RBCs separated from 18 pregnant women, and Y probe signals were observed in 67.3% of nucleated RBCs separated from 10 pregnant women. CONCLUSION: We confirmed that separated nucleated fetal RBCs can be used to identify fetal sex and chromosomal aneuploidies by FISH. Since nucleated RBCs from maternal origin were not excluded, further studies are needed to overcome this limitation.
Aneuploidy
;
Centrifugation
;
Female
;
Fluorescence
;
Humans
;
In Situ Hybridization
;
Pregnancy
;
Pregnant Women
;
Prenatal Diagnosis*
;
Sex Chromosomes
10.A Case of Protein Losing Enteropathy Caused by Primary Intestinal Lymphangiectasia.
Se Young LEE ; Ju Chun YEO ; Young Deuk YOUN ; Sae Rom KIM ; Young Lan KWON ; Hyon Uk RYU ; Jun Chul KIM ; Myung Kwon LEE ; Chang Keun PARK ; Sang Mun LEE
Korean Journal of Gastrointestinal Endoscopy 2006;33(5):307-312
Primary intestinal lymphangiectasia is a rare congenital cause of protein losing enteropathy that is characterized by chronic diarrhea, generalized edema, ascites, hypoproteinemia, hypoalbuminemia, and lymphopenia. We encountered an 18-year-old woman who suffered from longstanding diarrhea and progressive leg edema. The laboratory findings showed the typical features of this disorder. The presence of enteric protein loss was documented with the 24 hour fecal clearance of alpha(1)-antitrypsin and (99m)Tc human serum albumin scintigraphy. A duodenoscopy and biopsy showed scattered white spots and markedly dilated lymphatics in the tips of the villi, respectively. The patient's clinical symptoms improved after placing her on a high protein and low fat diet with medium chain triglyceride supplements.
Adolescent
;
Ascites
;
Biopsy
;
Dental Caries
;
Diarrhea
;
Diet
;
Duodenoscopy
;
Edema
;
Female
;
Humans
;
Hypoalbuminemia
;
Hypoproteinemia
;
Leg
;
Lymphopenia
;
Protein-Losing Enteropathies*
;
Radionuclide Imaging
;
Serum Albumin
;
Triglycerides