We report a 42-year-old female with a 20-year history of systemic lupus erythematosus who subsequently developed psoriasis vulgaris. She has been on chronic, erratic prednisone and hydroxychloroquine intake prior to appearance of psoriatic lesions. Hydroxychloroquine and glucocorticoids are possible triggers of this phenomenon. Both diseases have a shared susceptibility loci and a shared Th17 pathophysiologic pathway.Treatment with methotrexate and selected biologics can target both disease mechanisms.

Human ; Female ; Adult ; Hydroxychloroquine ; Glucocorticoids ; Methotrexate ; Biological Products ; Lupus Erythematosus, Systemic ; Psoriasis ; Precipitating Factors ; Disease Susceptibility