Blindness or serious visual impairment is a common and well known sequela of methanol intoxication in man, while other manifestations such as focal neurological deficits and abnormal brain CT scan are reported rarely. We experienced a case of acute methanol intoxication, which showed not only visual impairment but also bulbar symptoms and characteristic bilateral symmetrical hypodensity area in basal ganglia, especially putamen on brain CT scan. We tried 'pulse therapy'-continuouis dripping of methyl prednisolone (Solumedrol 1gm/day) for 5 days-with transient improvement of visual impairment, but bulbar symptoms were stationary. One month later, visual impairment was recurred, and the 'pulse therapy' was tried again but without benefit. On follow-up brain CT scan, the size of previous hypodensity area in basal ganglia was decreased.
Basal Ganglia ; Blindness ; Brain* ; Bulbar Palsy, Progressive* ; Follow-Up Studies ; Methanol* ; Prednisolone ; Putamen ; Tomography, X-Ray Computed* ; Vision Disorders

Laughter as an epileptic phenomenon is very uncommon. The introduction of the term gelastic epilepsy by Daly and Mulder (1957) may have resulted in less precision in diagnosis. Laughter does not necessarily include Mirth (gelos). Smiling may be volumtary or barely perceptible, whereas the laryngeal and respiratory components of laughter are more likely to be involuntary and are definite. To this time the loction of this epilepsy is said to be related with temporal lobe and hypothalamus. This case which we present with reviewing of the literature has paroxysmally a burst of loud, high-pitched laughter without any emotional expression. It suggests that at the production of this laughter some fasciorespiratory pathways might be involved, and that the start of this epileptic discharge is probably from a lesion of the orbito-frontal area.
Diagnosis ; Epilepsies, Partial* ; Epilepsy ; Hypothalamus ; Laughter ; Smiling ; Temporal Lobe

We present a case of bacterial menir gitis with spontaneous cerebrospinal rhinorrhea due to bony erosion by pituitary tumor. Brain CT and RI cisternography revealed direct bony erosion of both medial walls of sphenoid sinus which were considered as a portal of entry of bacterial meningitis. He was free from his symptoms by antimicrobial treatment and sugical repair.
Brain ; Cerebrospinal Fluid Rhinorrhea ; Meningitis, Bacterial* ; Pituitary Neoplasms* ; Sphenoid Sinus

Huntington's Disease (HD), an autosomal dominant disorder of mid-life onset, is characterized by progressive involuntary choreiform movement, psychological change and dementia. We present here two cases of Huntington's disease. One case has family history, but the other has none.
Chorea ; Dementia ; Humans ; Huntington Disease*

Spontaneous, nontraumatic midbrain hemorrhage is rare. The recent advent of CT scanning has led to recognition of smaller non fatal hemorrhage that could not have been diagnosed. About 19 cases of primary midbrrain hemorrhage have been reported in detail on the previous world literature. The authors recently encountered a hypertensive patient with small isolated mesencephalic hemorrhage documented by the CT scanning of brain, who clinically exhibited only bilateral ptosis and nuclear ophthalmoplegia. So we report a case of primary midbrain hemorrhage with the review of literature.
Brain ; Hemorrhage* ; Humans ; Mesencephalon* ; Ophthalmoplegia ; Tomography, X-Ray Computed

This is a case report of 47 year-old male patient with Huntington's chorea. Huntington's chorea is a progressive neurodegenerative disorder with autosomal dominant inheritance. The first symptoms of Huntington's chorea usually occur in the fourth to fifth decade and the gene is complete penetrance. The disease is characterized by both progressive motor abnormality, typically chorea, and intellectual deterioration commonly accompanied by prominent psychiatric symptoms including severe depression. Although the prevalence of Huntington's chorea is only 5-10 in 100,000 in Europe, the reported cases are extremely rare in this country until now.
Chorea ; Depression ; Europe ; Humans ; Huntington Disease* ; Male ; Middle Aged ; Neurodegenerative Diseases ; Penetrance ; Prevalence ; Wills

Herpes zoster myelitis is quite rare and it's MRI findings have not been reported. We report a patient who developed a progressive myelopathy after a characteristic herpes zoster skin lesions involving right C3 and C4 dermatomes. The lesions were recognizable in T1-weighted images of MRI as hypointense areas in the central portion of the long segment of the spinal cord, which became more prominent in T2-weighted image as increased signal intensities. In this patient computed tomographic metrizamide myelography (CTMM) showed no detectable intra or extramedullary lesion except a slight bulging of the cervical cord.
Herpes Zoster* ; Humans ; Magnetic Resonance Imaging ; Metrizamide ; Myelitis* ; Myelography ; Skin ; Spinal Cord ; Spinal Cord Diseases

No abstract available.
Dystonia Musculorum Deformans* ; Dystonia*

Delayed peripheral polyneuropathy caused by organophosphorus intoxication is not uncommon. This is a case report of 32 years old female with peripheral polyneuropathy which is appeared two weeks after organophosphorus poisoning. It is characterized by calves pain followed by minmal sensory change and predominant motor weakness affecting the distal part of the limbs. The electrophysiologic and pathologic studies support the clinical diagnosis. The exact pathogenesis is still debated, but phosphorylation of neurotoxic esterase (NTE), followed by "aging" process was suspected to play a role in the development of axonal degeneration.
Adult ; Axons ; Diagnosis ; Extremities ; Female ; Humans ; Organophosphate Poisoning ; Phosphorylation ; Polyneuropathies*

Both interictal Tc-99m hexamethyl-propyleneamine oxime single photon emission computed tomography (HM-PAO SPECT) brain scintigraphy was done in a patient with the syndrome of chronic encephalitis and epilepsy. The low density area in the temporo-occipital lobe on brain CT scan revealed decreased radioactivity during interictal state and it was reversed to increased radioactivity during ictal state on HM-PAO SPECT brain imaging. In authors' opinion, ictal and interictal Tc-99m HM-PAO SPECT brain scintigraphy could be a safe and convincing study for Searching epileptogenic foci.
Brain* ; Encephalitis* ; Epilepsy* ; Humans ; Neuroimaging ; Radioactivity ; Radionuclide Imaging* ; Tomography, Emission-Computed, Single-Photon* ; Tomography, X-Ray Computed